PRRG4 function reveals that Robo trafficking is evolutionarily conserved

Autores
Berni, Jimena
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Achieving a correct set of neuronal connections during development is key for a healthy functioningnervous system. Autism, which is characterised by impairments in social interaction,language, and range of interests, has been hypothesised to originate from defective synapticfunction and abnormal brain connectivity [1,2]. Moreover, genetic alterations such as the deficiencyin proline-rich carboxyglutamic acid protein 4 (PRRG4) have been associated withautistic features present in WAGR syndrome (Wilm´s tumour, aniridia, genitourinary anomaliesand ªmental retardationº). Therefore, understanding the genetic mechanisms underlyingthe assembly of brain circuits is likely to be essential for the design of new diagnostic tools andtherapeutic strategies for Autistic Spectrum Disorders (ASD). In this issue of PLOS Genetics,Justice et al. link genetic alterations and neural circuitry development, revealing a novel rolefor the PRRG4 as a regulator of Roundabout (Robo) receptor subcellular localization in thenervous system [3].
Fil: Berni, Jimena. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Roundabout
axon-pathfinding
autism
PRGG4
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/65328
Acceder
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network_name_str CONICET Digital (CONICET)
spelling PRRG4 function reveals that Robo trafficking is evolutionarily conservedBerni, JimenaRoundaboutaxon-pathfindingautismPRGG4https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Achieving a correct set of neuronal connections during development is key for a healthy functioningnervous system. Autism, which is characterised by impairments in social interaction,language, and range of interests, has been hypothesised to originate from defective synapticfunction and abnormal brain connectivity [1,2]. Moreover, genetic alterations such as the deficiencyin proline-rich carboxyglutamic acid protein 4 (PRRG4) have been associated withautistic features present in WAGR syndrome (Wilm´s tumour, aniridia, genitourinary anomaliesand ªmental retardationº). Therefore, understanding the genetic mechanisms underlyingthe assembly of brain circuits is likely to be essential for the design of new diagnostic tools andtherapeutic strategies for Autistic Spectrum Disorders (ASD). In this issue of PLOS Genetics,Justice et al. link genetic alterations and neural circuitry development, revealing a novel rolefor the PRRG4 as a regulator of Roundabout (Robo) receptor subcellular localization in thenervous system [3].Fil: Berni, Jimena. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPublic Library of Science2017-08-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/65328Berni, Jimena; PRRG4 function reveals that Robo trafficking is evolutionarily conserved; Public Library of Science; Plos Genetics; 13; 8; 13-8-2017; 1-3; e10069271553-7390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1006927info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006927info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:06:57Zoai:ri.conicet.gov.ar:11336/65328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:06:58.267CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv PRRG4 function reveals that Robo trafficking is evolutionarily conserved
title PRRG4 function reveals that Robo trafficking is evolutionarily conserved
spellingShingle PRRG4 function reveals that Robo trafficking is evolutionarily conserved
Berni, Jimena
Roundabout
axon-pathfinding
autism
PRGG4
title_short PRRG4 function reveals that Robo trafficking is evolutionarily conserved
title_full PRRG4 function reveals that Robo trafficking is evolutionarily conserved
title_fullStr PRRG4 function reveals that Robo trafficking is evolutionarily conserved
title_full_unstemmed PRRG4 function reveals that Robo trafficking is evolutionarily conserved
title_sort PRRG4 function reveals that Robo trafficking is evolutionarily conserved
dc.creator.none.fl_str_mv Berni, Jimena
author Berni, Jimena
author_facet Berni, Jimena
author_role author
dc.subject.none.fl_str_mv Roundabout
axon-pathfinding
autism
PRGG4
topic Roundabout
axon-pathfinding
autism
PRGG4
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Achieving a correct set of neuronal connections during development is key for a healthy functioningnervous system. Autism, which is characterised by impairments in social interaction,language, and range of interests, has been hypothesised to originate from defective synapticfunction and abnormal brain connectivity [1,2]. Moreover, genetic alterations such as the deficiencyin proline-rich carboxyglutamic acid protein 4 (PRRG4) have been associated withautistic features present in WAGR syndrome (Wilm´s tumour, aniridia, genitourinary anomaliesand ªmental retardationº). Therefore, understanding the genetic mechanisms underlyingthe assembly of brain circuits is likely to be essential for the design of new diagnostic tools andtherapeutic strategies for Autistic Spectrum Disorders (ASD). In this issue of PLOS Genetics,Justice et al. link genetic alterations and neural circuitry development, revealing a novel rolefor the PRRG4 as a regulator of Roundabout (Robo) receptor subcellular localization in thenervous system [3].
Fil: Berni, Jimena. University of Cambridge; Reino Unido. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Achieving a correct set of neuronal connections during development is key for a healthy functioningnervous system. Autism, which is characterised by impairments in social interaction,language, and range of interests, has been hypothesised to originate from defective synapticfunction and abnormal brain connectivity [1,2]. Moreover, genetic alterations such as the deficiencyin proline-rich carboxyglutamic acid protein 4 (PRRG4) have been associated withautistic features present in WAGR syndrome (Wilm´s tumour, aniridia, genitourinary anomaliesand ªmental retardationº). Therefore, understanding the genetic mechanisms underlyingthe assembly of brain circuits is likely to be essential for the design of new diagnostic tools andtherapeutic strategies for Autistic Spectrum Disorders (ASD). In this issue of PLOS Genetics,Justice et al. link genetic alterations and neural circuitry development, revealing a novel rolefor the PRRG4 as a regulator of Roundabout (Robo) receptor subcellular localization in thenervous system [3].
publishDate 2017
dc.date.none.fl_str_mv 2017-08-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/65328
Berni, Jimena; PRRG4 function reveals that Robo trafficking is evolutionarily conserved; Public Library of Science; Plos Genetics; 13; 8; 13-8-2017; 1-3; e1006927
1553-7390
CONICET Digital
CONICET
url http://hdl.handle.net/11336/65328
identifier_str_mv Berni, Jimena; PRRG4 function reveals that Robo trafficking is evolutionarily conserved; Public Library of Science; Plos Genetics; 13; 8; 13-8-2017; 1-3; e1006927
1553-7390
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1006927
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006927
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781377758887936
score 12.982451

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