Organ Preservation into the 2020s: The Era of Dynamic Intervention

Autores
Petrenko, Alexander; Carnevale, Matías Emanuel; Somov, Alexander; Osorio, Juliana Soledad; Rodríguez, Joaquin; Guibert, Edgardo Elvio; Fuller, Barry; Froghi, Farid
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Organ preservation has been of major importance ever sincetransplantation developed into a global clinical activity. Therelatively simple procedures were developed on a basiccomprehension of low-temperature biology as related to organsoutside the body. In the past decade, there has been asignificant increase in knowledge of the sequelae of effectsin preserved organs, and how dynamic intervention by perfusioncan be used to mitigate injury and improve the qualityof the donated organs. The present review focuses on(1) new information about the cell and molecular events impactingon ischemia/reperfusion injury during organ preservation,(2) strategies which use varied compositions and additivesin organ preservation solutions to deal with these,(3) clear definitions of the developing protocols for dynamicorgan perfusion preservation, (4) information on how thechoice of perfusion solutions can impact on desired attributesof dynamic organ perfusion, and (5) summary and futurehorizons.
Fil: Petrenko, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; Ucrania
Fil: Carnevale, Matías Emanuel. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Somov, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; Ucrania
Fil: Osorio, Juliana Soledad. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina
Fil: Rodríguez, Joaquin. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina
Fil: Guibert, Edgardo Elvio. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuller, Barry. Ucl Division Of Surgery And Interventional Sciences; Reino Unido
Fil: Froghi, Farid. Ucl Division Of Surgery And Interventional Sciences; Reino Unido
Materia
ORGAN PRESERVATION
ORGAN PRESERVATION SOLUTIONS
TRANSPLANTATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/110935
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Organ Preservation into the 2020s: The Era of Dynamic InterventionPetrenko, AlexanderCarnevale, Matías EmanuelSomov, AlexanderOsorio, Juliana SoledadRodríguez, JoaquinGuibert, Edgardo ElvioFuller, BarryFroghi, FaridORGAN PRESERVATIONORGAN PRESERVATION SOLUTIONSTRANSPLANTATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Organ preservation has been of major importance ever sincetransplantation developed into a global clinical activity. Therelatively simple procedures were developed on a basiccomprehension of low-temperature biology as related to organsoutside the body. In the past decade, there has been asignificant increase in knowledge of the sequelae of effectsin preserved organs, and how dynamic intervention by perfusioncan be used to mitigate injury and improve the qualityof the donated organs. The present review focuses on(1) new information about the cell and molecular events impactingon ischemia/reperfusion injury during organ preservation,(2) strategies which use varied compositions and additivesin organ preservation solutions to deal with these,(3) clear definitions of the developing protocols for dynamicorgan perfusion preservation, (4) information on how thechoice of perfusion solutions can impact on desired attributesof dynamic organ perfusion, and (5) summary and futurehorizons.Fil: Petrenko, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; UcraniaFil: Carnevale, Matías Emanuel. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Somov, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; UcraniaFil: Osorio, Juliana Soledad. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; ArgentinaFil: Rodríguez, Joaquin. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; ArgentinaFil: Guibert, Edgardo Elvio. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fuller, Barry. Ucl Division Of Surgery And Interventional Sciences; Reino UnidoFil: Froghi, Farid. Ucl Division Of Surgery And Interventional Sciences; Reino UnidoKarger2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/110935Petrenko, Alexander; Carnevale, Matías Emanuel; Somov, Alexander; Osorio, Juliana Soledad; Rodríguez, Joaquin; et al.; Organ Preservation into the 2020s: The Era of Dynamic Intervention; Karger; Transfusion Medicine And Hemotherapy; 5-2019; 1-221660-3796CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/499610info:eu-repo/semantics/altIdentifier/doi/10.1159/000499610info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:13:20Zoai:ri.conicet.gov.ar:11336/110935instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:13:20.753CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Organ Preservation into the 2020s: The Era of Dynamic Intervention
title Organ Preservation into the 2020s: The Era of Dynamic Intervention
spellingShingle Organ Preservation into the 2020s: The Era of Dynamic Intervention
Petrenko, Alexander
ORGAN PRESERVATION
ORGAN PRESERVATION SOLUTIONS
TRANSPLANTATION
title_short Organ Preservation into the 2020s: The Era of Dynamic Intervention
title_full Organ Preservation into the 2020s: The Era of Dynamic Intervention
title_fullStr Organ Preservation into the 2020s: The Era of Dynamic Intervention
title_full_unstemmed Organ Preservation into the 2020s: The Era of Dynamic Intervention
title_sort Organ Preservation into the 2020s: The Era of Dynamic Intervention
dc.creator.none.fl_str_mv Petrenko, Alexander
Carnevale, Matías Emanuel
Somov, Alexander
Osorio, Juliana Soledad
Rodríguez, Joaquin
Guibert, Edgardo Elvio
Fuller, Barry
Froghi, Farid
author Petrenko, Alexander
author_facet Petrenko, Alexander
Carnevale, Matías Emanuel
Somov, Alexander
Osorio, Juliana Soledad
Rodríguez, Joaquin
Guibert, Edgardo Elvio
Fuller, Barry
Froghi, Farid
author_role author
author2 Carnevale, Matías Emanuel
Somov, Alexander
Osorio, Juliana Soledad
Rodríguez, Joaquin
Guibert, Edgardo Elvio
Fuller, Barry
Froghi, Farid
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ORGAN PRESERVATION
ORGAN PRESERVATION SOLUTIONS
TRANSPLANTATION
topic ORGAN PRESERVATION
ORGAN PRESERVATION SOLUTIONS
TRANSPLANTATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Organ preservation has been of major importance ever sincetransplantation developed into a global clinical activity. Therelatively simple procedures were developed on a basiccomprehension of low-temperature biology as related to organsoutside the body. In the past decade, there has been asignificant increase in knowledge of the sequelae of effectsin preserved organs, and how dynamic intervention by perfusioncan be used to mitigate injury and improve the qualityof the donated organs. The present review focuses on(1) new information about the cell and molecular events impactingon ischemia/reperfusion injury during organ preservation,(2) strategies which use varied compositions and additivesin organ preservation solutions to deal with these,(3) clear definitions of the developing protocols for dynamicorgan perfusion preservation, (4) information on how thechoice of perfusion solutions can impact on desired attributesof dynamic organ perfusion, and (5) summary and futurehorizons.
Fil: Petrenko, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; Ucrania
Fil: Carnevale, Matías Emanuel. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Somov, Alexander. Institute For Problems Of Cryobiology And Cryomedicine; Ucrania
Fil: Osorio, Juliana Soledad. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina
Fil: Rodríguez, Joaquin. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina
Fil: Guibert, Edgardo Elvio. Universidad Nacional de Rosario. Secretaria de Ciencia y Técnica. Centro Binacional de Investigación en Criobiología Clínica y Aplicada; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fuller, Barry. Ucl Division Of Surgery And Interventional Sciences; Reino Unido
Fil: Froghi, Farid. Ucl Division Of Surgery And Interventional Sciences; Reino Unido
description Organ preservation has been of major importance ever sincetransplantation developed into a global clinical activity. Therelatively simple procedures were developed on a basiccomprehension of low-temperature biology as related to organsoutside the body. In the past decade, there has been asignificant increase in knowledge of the sequelae of effectsin preserved organs, and how dynamic intervention by perfusioncan be used to mitigate injury and improve the qualityof the donated organs. The present review focuses on(1) new information about the cell and molecular events impactingon ischemia/reperfusion injury during organ preservation,(2) strategies which use varied compositions and additivesin organ preservation solutions to deal with these,(3) clear definitions of the developing protocols for dynamicorgan perfusion preservation, (4) information on how thechoice of perfusion solutions can impact on desired attributesof dynamic organ perfusion, and (5) summary and futurehorizons.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/110935
Petrenko, Alexander; Carnevale, Matías Emanuel; Somov, Alexander; Osorio, Juliana Soledad; Rodríguez, Joaquin; et al.; Organ Preservation into the 2020s: The Era of Dynamic Intervention; Karger; Transfusion Medicine And Hemotherapy; 5-2019; 1-22
1660-3796
CONICET Digital
CONICET
url http://hdl.handle.net/11336/110935
identifier_str_mv Petrenko, Alexander; Carnevale, Matías Emanuel; Somov, Alexander; Osorio, Juliana Soledad; Rodríguez, Joaquin; et al.; Organ Preservation into the 2020s: The Era of Dynamic Intervention; Karger; Transfusion Medicine And Hemotherapy; 5-2019; 1-22
1660-3796
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/499610
info:eu-repo/semantics/altIdentifier/doi/10.1159/000499610
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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