Pedunculopontine arousal system physiology– deep brain stimulation (DBS)

Autores
Garcia Rill, Edgar; Luster, Brennon; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; Urbano Suarez, Francisco Jose
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires; Argentina
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
Materia
basal forebrain
calcium channels
gamma band activity
lateral hypothalamus
orexin
tuberomammillary
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13602
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pedunculopontine arousal system physiology– deep brain stimulation (DBS)Garcia Rill, EdgarLuster, BrennonD'Onofrio, StasiaMahaffey, SusanBisagno, VeronicaUrbano Suarez, Francisco Josebasal forebraincalcium channelsgamma band activitylateral hypothalamusorexintuberomammillaryhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados UnidosFil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados UnidosFil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados UnidosFil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados UnidosFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires; ArgentinaFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; ArgentinaElsevier Science2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13602Garcia Rill, Edgar; Luster, Brennon; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; et al.; Pedunculopontine arousal system physiology– deep brain stimulation (DBS); Elsevier Science; Sleep Science; 8; 3; 11-2015; 153-1611984-0659enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000590info:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.09.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:32Zoai:ri.conicet.gov.ar:11336/13602instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:33.085CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
title Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
spellingShingle Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
Garcia Rill, Edgar
basal forebrain
calcium channels
gamma band activity
lateral hypothalamus
orexin
tuberomammillary
title_short Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
title_full Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
title_fullStr Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
title_full_unstemmed Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
title_sort Pedunculopontine arousal system physiology– deep brain stimulation (DBS)
dc.creator.none.fl_str_mv Garcia Rill, Edgar
Luster, Brennon
D'Onofrio, Stasia
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author Garcia Rill, Edgar
author_facet Garcia Rill, Edgar
Luster, Brennon
D'Onofrio, Stasia
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author_role author
author2 Luster, Brennon
D'Onofrio, Stasia
Mahaffey, Susan
Bisagno, Veronica
Urbano Suarez, Francisco Jose
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv basal forebrain
calcium channels
gamma band activity
lateral hypothalamus
orexin
tuberomammillary
topic basal forebrain
calcium channels
gamma band activity
lateral hypothalamus
orexin
tuberomammillary
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
Fil: Garcia Rill, Edgar. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: D'Onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires; Argentina
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires; Argentina
description This review describes the wake/sleep symptoms present in Parkinson׳s disease, and the role of the pedunculopontine nucleus in these symptoms. The physiology of PPN cells is important not only because it is a major element of the reticular activating system, but also because it is a novel target for deep brain stimulation in the treatment of gait and postural deficits in Parkinson׳s disease. A greater understanding of the physiology of the target nuclei within the brainstem and basal ganglia, amassed over the past decades, has enabled increasingly better patient outcomes from deep brain stimulation for movement disorders.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13602
Garcia Rill, Edgar; Luster, Brennon; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; et al.; Pedunculopontine arousal system physiology– deep brain stimulation (DBS); Elsevier Science; Sleep Science; 8; 3; 11-2015; 153-161
1984-0659
url http://hdl.handle.net/11336/13602
identifier_str_mv Garcia Rill, Edgar; Luster, Brennon; D'Onofrio, Stasia; Mahaffey, Susan; Bisagno, Veronica; et al.; Pedunculopontine arousal system physiology– deep brain stimulation (DBS); Elsevier Science; Sleep Science; 8; 3; 11-2015; 153-161
1984-0659
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000590
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.09.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613634396782592
score 13.070432

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