Pedunculopontine arousal system physiology—Effects of psychostimulant abuse

Autores
Urbano Suarez, Francisco Jose; Bisagno, Veronica; Gonzalez, Betina; Rivero Echeto, Maria Celeste Solange; Muñiz, Javier A.; Luster, Brennon; D'onofrio, Stasia; Mahaffey, Susan; Garcia Rill, E
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal?s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Gonzalez, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Rivero Echeto, Maria Celeste Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Muñiz, Javier A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: D'onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Garcia Rill, E. University Of Arkansas For Medical Sciences; Estados Unidos
Materia
COCAINE
PEDUNCULOPONTINE
DOPAMINE
NICOTINE
CALCIUM CHANNELS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15172
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/15172
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pedunculopontine arousal system physiology—Effects of psychostimulant abuseUrbano Suarez, Francisco JoseBisagno, VeronicaGonzalez, BetinaRivero Echeto, Maria Celeste SolangeMuñiz, Javier A.Luster, BrennonD'onofrio, StasiaMahaffey, SusanGarcia Rill, ECOCAINEPEDUNCULOPONTINEDOPAMINENICOTINECALCIUM CHANNELShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal?s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administrationFil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Gonzalez, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Rivero Echeto, Maria Celeste Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Muñiz, Javier A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); ArgentinaFil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados UnidosFil: D'onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados UnidosFil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados UnidosFil: Garcia Rill, E. University Of Arkansas For Medical Sciences; Estados UnidosElsevier2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15172Urbano Suarez, Francisco Jose; Bisagno, Veronica; Gonzalez, Betina; Rivero Echeto, Maria Celeste Solange; Muñiz, Javier A.; et al.; Pedunculopontine arousal system physiology—Effects of psychostimulant abuse; Elsevier; Sleep Science; 8; 3; 11-2015; 162-1681984-0659enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000620/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.09.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:38:12Zoai:ri.conicet.gov.ar:11336/15172instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:38:13.092CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
title Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
spellingShingle Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
Urbano Suarez, Francisco Jose
COCAINE
PEDUNCULOPONTINE
DOPAMINE
NICOTINE
CALCIUM CHANNELS
title_short Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
title_full Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
title_fullStr Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
title_full_unstemmed Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
title_sort Pedunculopontine arousal system physiology—Effects of psychostimulant abuse
dc.creator.none.fl_str_mv Urbano Suarez, Francisco Jose
Bisagno, Veronica
Gonzalez, Betina
Rivero Echeto, Maria Celeste Solange
Muñiz, Javier A.
Luster, Brennon
D'onofrio, Stasia
Mahaffey, Susan
Garcia Rill, E
author Urbano Suarez, Francisco Jose
author_facet Urbano Suarez, Francisco Jose
Bisagno, Veronica
Gonzalez, Betina
Rivero Echeto, Maria Celeste Solange
Muñiz, Javier A.
Luster, Brennon
D'onofrio, Stasia
Mahaffey, Susan
Garcia Rill, E
author_role author
author2 Bisagno, Veronica
Gonzalez, Betina
Rivero Echeto, Maria Celeste Solange
Muñiz, Javier A.
Luster, Brennon
D'onofrio, Stasia
Mahaffey, Susan
Garcia Rill, E
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COCAINE
PEDUNCULOPONTINE
DOPAMINE
NICOTINE
CALCIUM CHANNELS
topic COCAINE
PEDUNCULOPONTINE
DOPAMINE
NICOTINE
CALCIUM CHANNELS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal?s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Gonzalez, Betina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Rivero Echeto, Maria Celeste Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Muñiz, Javier A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
Fil: Luster, Brennon. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: D'onofrio, Stasia. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Mahaffey, Susan. University Of Arkansas For Medical Sciences; Estados Unidos
Fil: Garcia Rill, E. University Of Arkansas For Medical Sciences; Estados Unidos
description This review describes the interactions between the pedunculopontine nucleus (PPN), the ventral tegmental area (VTA), and the thalamocortical system. Experiments using modulators of cholinergic receptors in the PPN clarified its role on psychostimulant-induced locomotion. PPN activation was found to be involved in the animal?s voluntary search for psychostimulants. Every PPN neuron is known to generate gamma band oscillations. Voltage-gated calcium channels are key elements in the generation and maintenance of gamma band activity of PPN neurons. Calcium channels are also key elements mediating psychostimulant-induced alterations in the thalamic targets of PPN output. Thus, the PPN is a key substrate for maintaining arousal and REM sleep, but also in modulating psychostimulant self-administration
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15172
Urbano Suarez, Francisco Jose; Bisagno, Veronica; Gonzalez, Betina; Rivero Echeto, Maria Celeste Solange; Muñiz, Javier A.; et al.; Pedunculopontine arousal system physiology—Effects of psychostimulant abuse; Elsevier; Sleep Science; 8; 3; 11-2015; 162-168
1984-0659
url http://hdl.handle.net/11336/15172
identifier_str_mv Urbano Suarez, Francisco Jose; Bisagno, Veronica; Gonzalez, Betina; Rivero Echeto, Maria Celeste Solange; Muñiz, Javier A.; et al.; Pedunculopontine arousal system physiology—Effects of psychostimulant abuse; Elsevier; Sleep Science; 8; 3; 11-2015; 162-168
1984-0659
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1984006315000620/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.slsci.2015.09.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613207296049152
score 13.070432

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