A Doppler effect in embryonic pattern formation

Autores
Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; Jülicher, Frank; Oates, Andrew C.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.
Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido
Fil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados Unidos
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido
Materia
Gene Expression Waves
Doppler Effect
Segmentation Clock
Clock And Wavefront
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29448

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network_name_str CONICET Digital (CONICET)
spelling A Doppler effect in embryonic pattern formationSoroldoni, DanieleJörg, David J.Morelli, Luis GuillermoRichmond, David L.Schindelin, JohannesJülicher, FrankOates, Andrew C.Gene Expression WavesDoppler EffectSegmentation ClockClock And Wavefronthttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino UnidoFil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados UnidosFil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino UnidoAmerican Association for the Advancement of Science2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29448Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-2250036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.1253089info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/345/6193/222info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:43Zoai:ri.conicet.gov.ar:11336/29448instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:43.773CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Doppler effect in embryonic pattern formation
title A Doppler effect in embryonic pattern formation
spellingShingle A Doppler effect in embryonic pattern formation
Soroldoni, Daniele
Gene Expression Waves
Doppler Effect
Segmentation Clock
Clock And Wavefront
title_short A Doppler effect in embryonic pattern formation
title_full A Doppler effect in embryonic pattern formation
title_fullStr A Doppler effect in embryonic pattern formation
title_full_unstemmed A Doppler effect in embryonic pattern formation
title_sort A Doppler effect in embryonic pattern formation
dc.creator.none.fl_str_mv Soroldoni, Daniele
Jörg, David J.
Morelli, Luis Guillermo
Richmond, David L.
Schindelin, Johannes
Jülicher, Frank
Oates, Andrew C.
author Soroldoni, Daniele
author_facet Soroldoni, Daniele
Jörg, David J.
Morelli, Luis Guillermo
Richmond, David L.
Schindelin, Johannes
Jülicher, Frank
Oates, Andrew C.
author_role author
author2 Jörg, David J.
Morelli, Luis Guillermo
Richmond, David L.
Schindelin, Johannes
Jülicher, Frank
Oates, Andrew C.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Gene Expression Waves
Doppler Effect
Segmentation Clock
Clock And Wavefront
topic Gene Expression Waves
Doppler Effect
Segmentation Clock
Clock And Wavefront
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.
Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido
Fil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados Unidos
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido
description During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.
publishDate 2014
dc.date.none.fl_str_mv 2014-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29448
Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-225
0036-8075
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29448
identifier_str_mv Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-225
0036-8075
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1253089
info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/345/6193/222
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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