A Doppler effect in embryonic pattern formation
- Autores
- Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; Jülicher, Frank; Oates, Andrew C.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.
Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido
Fil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania
Fil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados Unidos
Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania
Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido - Materia
-
Gene Expression Waves
Doppler Effect
Segmentation Clock
Clock And Wavefront - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/29448
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A Doppler effect in embryonic pattern formationSoroldoni, DanieleJörg, David J.Morelli, Luis GuillermoRichmond, David L.Schindelin, JohannesJülicher, FrankOates, Andrew C.Gene Expression WavesDoppler EffectSegmentation ClockClock And Wavefronthttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening.Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino UnidoFil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; AlemaniaFil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados UnidosFil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino UnidoAmerican Association for the Advancement of Science2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29448Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-2250036-8075CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1126/science.1253089info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/345/6193/222info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:31:43Zoai:ri.conicet.gov.ar:11336/29448instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:31:43.773CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A Doppler effect in embryonic pattern formation |
title |
A Doppler effect in embryonic pattern formation |
spellingShingle |
A Doppler effect in embryonic pattern formation Soroldoni, Daniele Gene Expression Waves Doppler Effect Segmentation Clock Clock And Wavefront |
title_short |
A Doppler effect in embryonic pattern formation |
title_full |
A Doppler effect in embryonic pattern formation |
title_fullStr |
A Doppler effect in embryonic pattern formation |
title_full_unstemmed |
A Doppler effect in embryonic pattern formation |
title_sort |
A Doppler effect in embryonic pattern formation |
dc.creator.none.fl_str_mv |
Soroldoni, Daniele Jörg, David J. Morelli, Luis Guillermo Richmond, David L. Schindelin, Johannes Jülicher, Frank Oates, Andrew C. |
author |
Soroldoni, Daniele |
author_facet |
Soroldoni, Daniele Jörg, David J. Morelli, Luis Guillermo Richmond, David L. Schindelin, Johannes Jülicher, Frank Oates, Andrew C. |
author_role |
author |
author2 |
Jörg, David J. Morelli, Luis Guillermo Richmond, David L. Schindelin, Johannes Jülicher, Frank Oates, Andrew C. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Gene Expression Waves Doppler Effect Segmentation Clock Clock And Wavefront |
topic |
Gene Expression Waves Doppler Effect Segmentation Clock Clock And Wavefront |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening. Fil: Soroldoni, Daniele. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido Fil: Jörg, David J.. Max Planck Institute for the Physics of Complex Systems; Alemania Fil: Morelli, Luis Guillermo. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Richmond, David L.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania Fil: Schindelin, Johannes. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. University of Wisconsin; Estados Unidos Fil: Jülicher, Frank. Max Planck Institute for the Physics of Complex Systems; Alemania Fil: Oates, Andrew C.. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. National Institute for Medical Research; Reino Unido |
description |
During embryonic development, temporal and spatial cues are coordinated to generate a segmented body axis. In sequentially segmenting animals, the rhythm of segmentation is reported to be controlled by the time scale of genetic oscillations that periodically trigger new segment formation. However, we present real-time measurements of genetic oscillations in zebrafish embryos showing that their time scale is not sufficient to explain the temporal period of segmentation. A second time scale, the rate of tissue shortening, contributes to the period of segmentation through a Doppler effect. This contribution is modulated by a gradual change in the oscillation profile across the tissue. We conclude that the rhythm of segmentation is an emergent property controlled by the time scale of genetic oscillations, the change of oscillation profile, and tissue shortening. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/29448 Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-225 0036-8075 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/29448 |
identifier_str_mv |
Soroldoni, Daniele; Jörg, David J.; Morelli, Luis Guillermo; Richmond, David L.; Schindelin, Johannes; et al.; A Doppler effect in embryonic pattern formation; American Association for the Advancement of Science; Science; 345; 6193; 7-2014; 222-225 0036-8075 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1126/science.1253089 info:eu-repo/semantics/altIdentifier/url/http://science.sciencemag.org/content/345/6193/222 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
publisher.none.fl_str_mv |
American Association for the Advancement of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |