Kidney regeneration: common themes from the embryo to the adult

Autores
Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.
Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Groh, Eric D.. University of Pittsburgh; Estados Unidos
Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos
Fil: Davidson, Alan J.. The University of Auckland; Nueva Zelanda
Fil: Hukriede, Neil A.. University of Pittsburgh; Estados Unidos
Materia
Regeneration
Development
Kidney
Organogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32180
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Kidney regeneration: common themes from the embryo to the adultCirio, Maria Ceciliade Groh, Eric D.de Caestecker, Mark P.Davidson, Alan J.Hukriede, Neil A.RegenerationDevelopmentKidneyOrganogenesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Groh, Eric D.. University of Pittsburgh; Estados UnidosFil: de Caestecker, Mark P.. Vanderbilt University; Estados UnidosFil: Davidson, Alan J.. The University of Auckland; Nueva ZelandaFil: Hukriede, Neil A.. University of Pittsburgh; Estados UnidosSpringer2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32180Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-5640931-041X1432-198XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00467-013-2597-2info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-013-2597-2info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944192/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:32:36Zoai:ri.conicet.gov.ar:11336/32180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:32:37.187CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Kidney regeneration: common themes from the embryo to the adult
title Kidney regeneration: common themes from the embryo to the adult
spellingShingle Kidney regeneration: common themes from the embryo to the adult
Cirio, Maria Cecilia
Regeneration
Development
Kidney
Organogenesis
title_short Kidney regeneration: common themes from the embryo to the adult
title_full Kidney regeneration: common themes from the embryo to the adult
title_fullStr Kidney regeneration: common themes from the embryo to the adult
title_full_unstemmed Kidney regeneration: common themes from the embryo to the adult
title_sort Kidney regeneration: common themes from the embryo to the adult
dc.creator.none.fl_str_mv Cirio, Maria Cecilia
de Groh, Eric D.
de Caestecker, Mark P.
Davidson, Alan J.
Hukriede, Neil A.
author Cirio, Maria Cecilia
author_facet Cirio, Maria Cecilia
de Groh, Eric D.
de Caestecker, Mark P.
Davidson, Alan J.
Hukriede, Neil A.
author_role author
author2 de Groh, Eric D.
de Caestecker, Mark P.
Davidson, Alan J.
Hukriede, Neil A.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Regeneration
Development
Kidney
Organogenesis
topic Regeneration
Development
Kidney
Organogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.
Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Groh, Eric D.. University of Pittsburgh; Estados Unidos
Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos
Fil: Davidson, Alan J.. The University of Auckland; Nueva Zelanda
Fil: Hukriede, Neil A.. University of Pittsburgh; Estados Unidos
description The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32180
Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-564
0931-041X
1432-198X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32180
identifier_str_mv Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-564
0931-041X
1432-198X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s00467-013-2597-2
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-013-2597-2
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944192/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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