Kidney regeneration: common themes from the embryo to the adult
- Autores
- Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.
Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: de Groh, Eric D.. University of Pittsburgh; Estados Unidos
Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos
Fil: Davidson, Alan J.. The University of Auckland; Nueva Zelanda
Fil: Hukriede, Neil A.. University of Pittsburgh; Estados Unidos - Materia
-
Regeneration
Development
Kidney
Organogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/32180
Ver los metadatos del registro completo
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Kidney regeneration: common themes from the embryo to the adultCirio, Maria Ceciliade Groh, Eric D.de Caestecker, Mark P.Davidson, Alan J.Hukriede, Neil A.RegenerationDevelopmentKidneyOrganogenesishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney.Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: de Groh, Eric D.. University of Pittsburgh; Estados UnidosFil: de Caestecker, Mark P.. Vanderbilt University; Estados UnidosFil: Davidson, Alan J.. The University of Auckland; Nueva ZelandaFil: Hukriede, Neil A.. University of Pittsburgh; Estados UnidosSpringer2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32180Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-5640931-041X1432-198XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00467-013-2597-2info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-013-2597-2info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944192/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:59Zoai:ri.conicet.gov.ar:11336/32180instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:00.22CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Kidney regeneration: common themes from the embryo to the adult |
title |
Kidney regeneration: common themes from the embryo to the adult |
spellingShingle |
Kidney regeneration: common themes from the embryo to the adult Cirio, Maria Cecilia Regeneration Development Kidney Organogenesis |
title_short |
Kidney regeneration: common themes from the embryo to the adult |
title_full |
Kidney regeneration: common themes from the embryo to the adult |
title_fullStr |
Kidney regeneration: common themes from the embryo to the adult |
title_full_unstemmed |
Kidney regeneration: common themes from the embryo to the adult |
title_sort |
Kidney regeneration: common themes from the embryo to the adult |
dc.creator.none.fl_str_mv |
Cirio, Maria Cecilia de Groh, Eric D. de Caestecker, Mark P. Davidson, Alan J. Hukriede, Neil A. |
author |
Cirio, Maria Cecilia |
author_facet |
Cirio, Maria Cecilia de Groh, Eric D. de Caestecker, Mark P. Davidson, Alan J. Hukriede, Neil A. |
author_role |
author |
author2 |
de Groh, Eric D. de Caestecker, Mark P. Davidson, Alan J. Hukriede, Neil A. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Regeneration Development Kidney Organogenesis |
topic |
Regeneration Development Kidney Organogenesis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney. Fil: Cirio, Maria Cecilia. University of Pittsburgh; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: de Groh, Eric D.. University of Pittsburgh; Estados Unidos Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos Fil: Davidson, Alan J.. The University of Auckland; Nueva Zelanda Fil: Hukriede, Neil A.. University of Pittsburgh; Estados Unidos |
description |
The vertebrate kidney has an inherent ability to regenerate following acute damage. Successful regeneration of the injured kidney requires the rapid replacement of damaged tubular epithelial cells and reconstitution of normal tubular function. Identifying the cells that participate in the regeneration process as well as the molecular mechanisms involved may reveal therapeutic targets for the treatment of kidney disease. Renal regeneration is associated with the expression of genetic pathways that are necessary for kidney organogenesis, suggesting that the regenerating tubular epithelium may be “reprogrammed” to a less-differentiated, progenitor state. This review will highlight data from various vertebrate models supporting the hypothesis that nephrogenic genes are reactivated as part of the process of kidney regeneration following acute kidney injury (AKI). Emphasis will be placed on the reactivation of developmental pathways and how our understanding of the resulting regeneration process may be enhanced by lessons learned in the embryonic kidney. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/32180 Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-564 0931-041X 1432-198X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/32180 |
identifier_str_mv |
Cirio, Maria Cecilia; de Groh, Eric D.; de Caestecker, Mark P.; Davidson, Alan J.; Hukriede, Neil A.; Kidney regeneration: common themes from the embryo to the adult; Springer; Pediatric Nephrology; 29; 4; 9-2013; 553-564 0931-041X 1432-198X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00467-013-2597-2 info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00467-013-2597-2 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944192/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |