Zebrafish Models of Kidney Damage and Repair

Autores
Cirio, Maria Cecilia; de Caestecker, Mark P.; Hukriede, Neil A.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The vertebrate kidney possesses the capacity to repair damaged nephrons, and this potential is conserved regardless of the complexity of species-specific kidneys. However, many aquatic vertebrates possess the ability to not only repair existing nephrons, but also generate new nephrons after injury. Adult zebrafish have the ability to recover from acute renal injury not only by replacing lost injured epithelial cells of endogenous nephrons, but by also generating de novo nephrons. This strong regeneration potential, along with other unique characteristics such as the high degree of genetic conservation with humans, the ease of harvesting externally fertilized, transparent embryos, the accessibility to larval and adult kidneys, and the ability to perform whole organism phenotypic small molecule screens, has positioned zebrafish as a unique vertebrate model to study kidney injury. In this review, we provide an overview of the contribution of zebrafish larvae/adult studies to the understanding of renal regeneration, diseases, and therapeutic discovery.
Fil: Cirio, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos
Fil: Hukriede, Neil A.. University Of Pittsburgh; Estados Unidos
Materia
Zebrafish
Kidney
Regeneration
Injury
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20168
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Zebrafish Models of Kidney Damage and RepairCirio, Maria Ceciliade Caestecker, Mark P.Hukriede, Neil A.ZebrafishKidneyRegenerationInjuryhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The vertebrate kidney possesses the capacity to repair damaged nephrons, and this potential is conserved regardless of the complexity of species-specific kidneys. However, many aquatic vertebrates possess the ability to not only repair existing nephrons, but also generate new nephrons after injury. Adult zebrafish have the ability to recover from acute renal injury not only by replacing lost injured epithelial cells of endogenous nephrons, but by also generating de novo nephrons. This strong regeneration potential, along with other unique characteristics such as the high degree of genetic conservation with humans, the ease of harvesting externally fertilized, transparent embryos, the accessibility to larval and adult kidneys, and the ability to perform whole organism phenotypic small molecule screens, has positioned zebrafish as a unique vertebrate model to study kidney injury. In this review, we provide an overview of the contribution of zebrafish larvae/adult studies to the understanding of renal regeneration, diseases, and therapeutic discovery.Fil: Cirio, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: de Caestecker, Mark P.. Vanderbilt University; Estados UnidosFil: Hukriede, Neil A.. University Of Pittsburgh; Estados UnidosSpringer2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20168Cirio, Maria Cecilia; de Caestecker, Mark P.; Hukriede, Neil A.; Zebrafish Models of Kidney Damage and Repair; Springer; Current Pathobiology Reports; 3; 2; 6-2015; 163-1702167-485XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s40139-015-0080-4info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40139-015-0080-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:35:13Zoai:ri.conicet.gov.ar:11336/20168instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:35:14.148CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zebrafish Models of Kidney Damage and Repair
title Zebrafish Models of Kidney Damage and Repair
spellingShingle Zebrafish Models of Kidney Damage and Repair
Cirio, Maria Cecilia
Zebrafish
Kidney
Regeneration
Injury
title_short Zebrafish Models of Kidney Damage and Repair
title_full Zebrafish Models of Kidney Damage and Repair
title_fullStr Zebrafish Models of Kidney Damage and Repair
title_full_unstemmed Zebrafish Models of Kidney Damage and Repair
title_sort Zebrafish Models of Kidney Damage and Repair
dc.creator.none.fl_str_mv Cirio, Maria Cecilia
de Caestecker, Mark P.
Hukriede, Neil A.
author Cirio, Maria Cecilia
author_facet Cirio, Maria Cecilia
de Caestecker, Mark P.
Hukriede, Neil A.
author_role author
author2 de Caestecker, Mark P.
Hukriede, Neil A.
author2_role author
author
dc.subject.none.fl_str_mv Zebrafish
Kidney
Regeneration
Injury
topic Zebrafish
Kidney
Regeneration
Injury
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The vertebrate kidney possesses the capacity to repair damaged nephrons, and this potential is conserved regardless of the complexity of species-specific kidneys. However, many aquatic vertebrates possess the ability to not only repair existing nephrons, but also generate new nephrons after injury. Adult zebrafish have the ability to recover from acute renal injury not only by replacing lost injured epithelial cells of endogenous nephrons, but by also generating de novo nephrons. This strong regeneration potential, along with other unique characteristics such as the high degree of genetic conservation with humans, the ease of harvesting externally fertilized, transparent embryos, the accessibility to larval and adult kidneys, and the ability to perform whole organism phenotypic small molecule screens, has positioned zebrafish as a unique vertebrate model to study kidney injury. In this review, we provide an overview of the contribution of zebrafish larvae/adult studies to the understanding of renal regeneration, diseases, and therapeutic discovery.
Fil: Cirio, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: de Caestecker, Mark P.. Vanderbilt University; Estados Unidos
Fil: Hukriede, Neil A.. University Of Pittsburgh; Estados Unidos
description The vertebrate kidney possesses the capacity to repair damaged nephrons, and this potential is conserved regardless of the complexity of species-specific kidneys. However, many aquatic vertebrates possess the ability to not only repair existing nephrons, but also generate new nephrons after injury. Adult zebrafish have the ability to recover from acute renal injury not only by replacing lost injured epithelial cells of endogenous nephrons, but by also generating de novo nephrons. This strong regeneration potential, along with other unique characteristics such as the high degree of genetic conservation with humans, the ease of harvesting externally fertilized, transparent embryos, the accessibility to larval and adult kidneys, and the ability to perform whole organism phenotypic small molecule screens, has positioned zebrafish as a unique vertebrate model to study kidney injury. In this review, we provide an overview of the contribution of zebrafish larvae/adult studies to the understanding of renal regeneration, diseases, and therapeutic discovery.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20168
Cirio, Maria Cecilia; de Caestecker, Mark P.; Hukriede, Neil A.; Zebrafish Models of Kidney Damage and Repair; Springer; Current Pathobiology Reports; 3; 2; 6-2015; 163-170
2167-485X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20168
identifier_str_mv Cirio, Maria Cecilia; de Caestecker, Mark P.; Hukriede, Neil A.; Zebrafish Models of Kidney Damage and Repair; Springer; Current Pathobiology Reports; 3; 2; 6-2015; 163-170
2167-485X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s40139-015-0080-4
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40139-015-0080-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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