Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia

Autores
Garcés, María F.; Vallejo, Sergio A.; Sanchez, Elizabeth; Palomino Palomino, Miguel A.; Leal, Luis G.; Ángel Muller, Edith; Diaz Cruz, Luz A.; Ruíz Parra, Ariel Iván; González Clavijo, Angélica M.; Castaño, Justo P.; Abba, Martín Carlos; Lacunza, Ezequiel; Diéguez, Carlos; Nogueiras, Rubén; Caminos, Jorge E.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case–control study, FST serum levels during normal pregnancy and correlate it with the FST profile in preeclamptic pregnant women, normal pregnant women followed 3 months postpartum and eumenorrheic nonpregnant women throughout the menstrual cycle. Subjects and Methods: Follistatin serum levels determined by ELISA, biochemical and anthropometric variables were measured in normal pregnant (n = 28) and preeclamptic (n = 20) women during three periods of gestation. In addition, FST serum levels were measured in a subset of normal pregnant women (n = 13) followed 3 months postpartum and in eumenorrheic nonpregnant women (n = 20) during the follicular and luteal phases of the menstrual cycle. Results: Follistatin serum levels in the eumenorrheic nonpregnant and postpartum group were significantly lower when compared to levels throughout gestation (P < 0·01). Serum FST levels increased in each period of pregnancy analysed, being significantly higher towards the end of gestation (P < 0·01). FST levels were lower in late pregnancy in preeclamptic women compared to normal pregnant women (P < 0·05). Finally, FST levels were higher in the luteal phase when compared with the follicular phase of the menstrual cycle (P < 0·05). Conclusions: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system.
Fil: Garcés, María F.. Universidad Nacional de Colombia; Colombia
Fil: Vallejo, Sergio A.. Universidad Nacional de Colombia; Colombia
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
Fil: Palomino Palomino, Miguel A.. Universidad Nacional de Colombia; Colombia
Fil: Leal, Luis G.. Universidad Nacional de Colombia; Colombia
Fil: Ángel Muller, Edith. Universidad Nacional de Colombia; Colombia
Fil: Diaz Cruz, Luz A.. Universidad Nacional de Colombia; Colombia
Fil: Ruíz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia
Fil: González Clavijo, Angélica M.. Universidad Nacional de Colombia; Colombia
Fil: Castaño, Justo P.. Universidad de Córdoba; España. CIBER de Obesidad y Nutrición; España
Fil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España
Fil: Caminos, Jorge E.. Universidad Nacional de Colombia; Colombia
Materia
Follistatin
Preeclampsia
Rat
Reproduction
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13712
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/13712
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsiaGarcés, María F.Vallejo, Sergio A.Sanchez, ElizabethPalomino Palomino, Miguel A.Leal, Luis G.Ángel Muller, EdithDiaz Cruz, Luz A.Ruíz Parra, Ariel IvánGonzález Clavijo, Angélica M.Castaño, Justo P.Abba, Martín CarlosLacunza, EzequielDiéguez, CarlosNogueiras, RubénCaminos, Jorge E.FollistatinPreeclampsiaRatReproductionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Objective: Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case–control study, FST serum levels during normal pregnancy and correlate it with the FST profile in preeclamptic pregnant women, normal pregnant women followed 3 months postpartum and eumenorrheic nonpregnant women throughout the menstrual cycle. Subjects and Methods: Follistatin serum levels determined by ELISA, biochemical and anthropometric variables were measured in normal pregnant (n = 28) and preeclamptic (n = 20) women during three periods of gestation. In addition, FST serum levels were measured in a subset of normal pregnant women (n = 13) followed 3 months postpartum and in eumenorrheic nonpregnant women (n = 20) during the follicular and luteal phases of the menstrual cycle. Results: Follistatin serum levels in the eumenorrheic nonpregnant and postpartum group were significantly lower when compared to levels throughout gestation (P < 0·01). Serum FST levels increased in each period of pregnancy analysed, being significantly higher towards the end of gestation (P < 0·01). FST levels were lower in late pregnancy in preeclamptic women compared to normal pregnant women (P < 0·05). Finally, FST levels were higher in the luteal phase when compared with the follicular phase of the menstrual cycle (P < 0·05). Conclusions: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system.Fil: Garcés, María F.. Universidad Nacional de Colombia; ColombiaFil: Vallejo, Sergio A.. Universidad Nacional de Colombia; ColombiaFil: Sanchez, Elizabeth. Universidad Nacional de Colombia; ColombiaFil: Palomino Palomino, Miguel A.. Universidad Nacional de Colombia; ColombiaFil: Leal, Luis G.. Universidad Nacional de Colombia; ColombiaFil: Ángel Muller, Edith. Universidad Nacional de Colombia; ColombiaFil: Diaz Cruz, Luz A.. Universidad Nacional de Colombia; ColombiaFil: Ruíz Parra, Ariel Iván. Universidad Nacional de Colombia; ColombiaFil: González Clavijo, Angélica M.. Universidad Nacional de Colombia; ColombiaFil: Castaño, Justo P.. Universidad de Córdoba; España. CIBER de Obesidad y Nutrición; EspañaFil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diéguez, Carlos. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; EspañaFil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; EspañaFil: Caminos, Jorge E.. Universidad Nacional de Colombia; ColombiaWiley2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13712Garcés, María F.; Vallejo, Sergio A.; Sanchez, Elizabeth; Palomino Palomino, Miguel A.; Leal, Luis G.; et al.; Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia; Wiley; Clinical Endocrinology; 83; 2; 8-2015; 229–2350300-0664enginfo:eu-repo/semantics/altIdentifier/doi/10.1111/cen.12715info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cen.12715/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:45Zoai:ri.conicet.gov.ar:11336/13712instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:45.259CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
title Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
spellingShingle Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
Garcés, María F.
Follistatin
Preeclampsia
Rat
Reproduction
title_short Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
title_full Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
title_fullStr Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
title_full_unstemmed Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
title_sort Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia
dc.creator.none.fl_str_mv Garcés, María F.
Vallejo, Sergio A.
Sanchez, Elizabeth
Palomino Palomino, Miguel A.
Leal, Luis G.
Ángel Muller, Edith
Diaz Cruz, Luz A.
Ruíz Parra, Ariel Iván
González Clavijo, Angélica M.
Castaño, Justo P.
Abba, Martín Carlos
Lacunza, Ezequiel
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
author Garcés, María F.
author_facet Garcés, María F.
Vallejo, Sergio A.
Sanchez, Elizabeth
Palomino Palomino, Miguel A.
Leal, Luis G.
Ángel Muller, Edith
Diaz Cruz, Luz A.
Ruíz Parra, Ariel Iván
González Clavijo, Angélica M.
Castaño, Justo P.
Abba, Martín Carlos
Lacunza, Ezequiel
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
author_role author
author2 Vallejo, Sergio A.
Sanchez, Elizabeth
Palomino Palomino, Miguel A.
Leal, Luis G.
Ángel Muller, Edith
Diaz Cruz, Luz A.
Ruíz Parra, Ariel Iván
González Clavijo, Angélica M.
Castaño, Justo P.
Abba, Martín Carlos
Lacunza, Ezequiel
Diéguez, Carlos
Nogueiras, Rubén
Caminos, Jorge E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Follistatin
Preeclampsia
Rat
Reproduction
topic Follistatin
Preeclampsia
Rat
Reproduction
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective: Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case–control study, FST serum levels during normal pregnancy and correlate it with the FST profile in preeclamptic pregnant women, normal pregnant women followed 3 months postpartum and eumenorrheic nonpregnant women throughout the menstrual cycle. Subjects and Methods: Follistatin serum levels determined by ELISA, biochemical and anthropometric variables were measured in normal pregnant (n = 28) and preeclamptic (n = 20) women during three periods of gestation. In addition, FST serum levels were measured in a subset of normal pregnant women (n = 13) followed 3 months postpartum and in eumenorrheic nonpregnant women (n = 20) during the follicular and luteal phases of the menstrual cycle. Results: Follistatin serum levels in the eumenorrheic nonpregnant and postpartum group were significantly lower when compared to levels throughout gestation (P < 0·01). Serum FST levels increased in each period of pregnancy analysed, being significantly higher towards the end of gestation (P < 0·01). FST levels were lower in late pregnancy in preeclamptic women compared to normal pregnant women (P < 0·05). Finally, FST levels were higher in the luteal phase when compared with the follicular phase of the menstrual cycle (P < 0·05). Conclusions: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system.
Fil: Garcés, María F.. Universidad Nacional de Colombia; Colombia
Fil: Vallejo, Sergio A.. Universidad Nacional de Colombia; Colombia
Fil: Sanchez, Elizabeth. Universidad Nacional de Colombia; Colombia
Fil: Palomino Palomino, Miguel A.. Universidad Nacional de Colombia; Colombia
Fil: Leal, Luis G.. Universidad Nacional de Colombia; Colombia
Fil: Ángel Muller, Edith. Universidad Nacional de Colombia; Colombia
Fil: Diaz Cruz, Luz A.. Universidad Nacional de Colombia; Colombia
Fil: Ruíz Parra, Ariel Iván. Universidad Nacional de Colombia; Colombia
Fil: González Clavijo, Angélica M.. Universidad Nacional de Colombia; Colombia
Fil: Castaño, Justo P.. Universidad de Córdoba; España. CIBER de Obesidad y Nutrición; España
Fil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lacunza, Ezequiel. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Centro de Investigaciones Inmunologicas Basicas y Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diéguez, Carlos. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España
Fil: Nogueiras, Rubén. Universidad de Santiago de Compostela; España. CIBER de Obesidad y Nutrición; España
Fil: Caminos, Jorge E.. Universidad Nacional de Colombia; Colombia
description Objective: Follistatin (FST) is a regulator of the biological activity of activin A (Act A), binding and blocking it, which could contribute to the modulation of its pro-inflammatory activity during pregnancy. We sought to investigate, in this nested case–control study, FST serum levels during normal pregnancy and correlate it with the FST profile in preeclamptic pregnant women, normal pregnant women followed 3 months postpartum and eumenorrheic nonpregnant women throughout the menstrual cycle. Subjects and Methods: Follistatin serum levels determined by ELISA, biochemical and anthropometric variables were measured in normal pregnant (n = 28) and preeclamptic (n = 20) women during three periods of gestation. In addition, FST serum levels were measured in a subset of normal pregnant women (n = 13) followed 3 months postpartum and in eumenorrheic nonpregnant women (n = 20) during the follicular and luteal phases of the menstrual cycle. Results: Follistatin serum levels in the eumenorrheic nonpregnant and postpartum group were significantly lower when compared to levels throughout gestation (P < 0·01). Serum FST levels increased in each period of pregnancy analysed, being significantly higher towards the end of gestation (P < 0·01). FST levels were lower in late pregnancy in preeclamptic women compared to normal pregnant women (P < 0·05). Finally, FST levels were higher in the luteal phase when compared with the follicular phase of the menstrual cycle (P < 0·05). Conclusions: These analyses would permit the consideration that changes in FST levels during pregnancy contribute to the control of the Act A system.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13712
Garcés, María F.; Vallejo, Sergio A.; Sanchez, Elizabeth; Palomino Palomino, Miguel A.; Leal, Luis G.; et al.; Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia; Wiley; Clinical Endocrinology; 83; 2; 8-2015; 229–235
0300-0664
url http://hdl.handle.net/11336/13712
identifier_str_mv Garcés, María F.; Vallejo, Sergio A.; Sanchez, Elizabeth; Palomino Palomino, Miguel A.; Leal, Luis G.; et al.; Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia; Wiley; Clinical Endocrinology; 83; 2; 8-2015; 229–235
0300-0664
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/cen.12715
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cen.12715/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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