Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats
- Autores
- Macova, Miroslava; Armando, Maria Ines; Zhou, Jin; Baiardi, Gustavo Carlos; Tyurmin, Dmitri; Larrayoz Roldan, Ignacio M.; Saavedra, Juan M.
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression,decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were:normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression, decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were: normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.
Fil: Macova, Miroslava. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos
Fil: Armando, Maria Ines. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos
Fil: Zhou, Jin. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos
Fil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina
Fil: Tyurmin, Dmitri. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos
Fil: Larrayoz Roldan, Ignacio M.. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos
Fil: Saavedra, Juan M.. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos - Materia
-
RENIN ANGIOTENSIN SYSTEM
ANGIOTENSIN II
AT 1 RECEPTORS
ADRENALL MEDULA
ADRENAL CORTEX - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/58411
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Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized ratsMacova, MiroslavaArmando, Maria InesZhou, JinBaiardi, Gustavo CarlosTyurmin, DmitriLarrayoz Roldan, Ignacio M.Saavedra, Juan M.RENIN ANGIOTENSIN SYSTEMANGIOTENSIN IIAT 1 RECEPTORSADRENALL MEDULAADRENAL CORTEXhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression,decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were:normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression, decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were: normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.Fil: Macova, Miroslava. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Armando, Maria Ines. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Zhou, Jin. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Tyurmin, Dmitri. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Larrayoz Roldan, Ignacio M.. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosFil: Saavedra, Juan M.. National Institute of Mental Health. Department of Health and Human Services; Estados UnidosKarger2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/58411Macova, Miroslava; Armando, Maria Ines; Zhou, Jin; Baiardi, Gustavo Carlos; Tyurmin, Dmitri; et al.; Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats; Karger; Neuroendocrinology; 88; 4; 12-2008; 276-2860028-38351423-0194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/150977info:eu-repo/semantics/altIdentifier/doi/10.1159%2F000150977info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:04Zoai:ri.conicet.gov.ar:11336/58411instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:05.087CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
title |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
spellingShingle |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats Macova, Miroslava RENIN ANGIOTENSIN SYSTEM ANGIOTENSIN II AT 1 RECEPTORS ADRENALL MEDULA ADRENAL CORTEX |
title_short |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
title_full |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
title_fullStr |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
title_full_unstemmed |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
title_sort |
Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats |
dc.creator.none.fl_str_mv |
Macova, Miroslava Armando, Maria Ines Zhou, Jin Baiardi, Gustavo Carlos Tyurmin, Dmitri Larrayoz Roldan, Ignacio M. Saavedra, Juan M. |
author |
Macova, Miroslava |
author_facet |
Macova, Miroslava Armando, Maria Ines Zhou, Jin Baiardi, Gustavo Carlos Tyurmin, Dmitri Larrayoz Roldan, Ignacio M. Saavedra, Juan M. |
author_role |
author |
author2 |
Armando, Maria Ines Zhou, Jin Baiardi, Gustavo Carlos Tyurmin, Dmitri Larrayoz Roldan, Ignacio M. Saavedra, Juan M. |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
RENIN ANGIOTENSIN SYSTEM ANGIOTENSIN II AT 1 RECEPTORS ADRENALL MEDULA ADRENAL CORTEX |
topic |
RENIN ANGIOTENSIN SYSTEM ANGIOTENSIN II AT 1 RECEPTORS ADRENALL MEDULA ADRENAL CORTEX |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression,decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were:normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression, decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were: normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy. Fil: Macova, Miroslava. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos Fil: Armando, Maria Ines. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos Fil: Zhou, Jin. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos Fil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; Argentina Fil: Tyurmin, Dmitri. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos Fil: Larrayoz Roldan, Ignacio M.. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos Fil: Saavedra, Juan M.. National Institute of Mental Health. Department of Health and Human Services; Estados Unidos |
description |
We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression,decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were:normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy.We studied the effect of ovariectomy and estrogen replacement on expression of adrenal angiotensin II AT 1 and AT 2 receptors, aldosterone content, catecholamine synthesis, and the transcription factor Fos-related antigen 2 (Fra-2). Ovariectomy increased AT 1 receptor expression in the adrenal zona glomerulosa and medulla, and decreased adrenomedullary catecholamine content and Fra-2 expression when compared to intact female rats. In the zona glomerulosa, estrogen replacement normalized AT 1 receptor expression, decreased AT 1B receptor mRNA, and increased AT 2 receptor expression and mRNA. Estrogen treatment decreased adrenal aldosterone content. In the adrenal medulla, the effects of estrogen replacement were: normalized AT 1 receptor expression, increased AT 2 receptor expression, AT 2 receptor mRNA, and tyrosine hydroxylase mRNA, and normalized Fra-2 expression and catecholamine content. We demonstrate that the constitutive adrenal expression of AT 1 receptors, catecholamine synthesis and Fra-2 expression are partially under the control of reproductive hormones. Our results suggest that estrogen treatment decreases aldosterone production through AT 1 receptor downregulation and AT 2 receptor upregulation. AT 2 receptor upregulation and modulation of Fra-2 expression may participate in the estrogen-dependent normalization of adrenomedullary catecholamine synthesis in ovariectomized rats. The AT 2 receptor upregulation and the decrease in AT 1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/58411 Macova, Miroslava; Armando, Maria Ines; Zhou, Jin; Baiardi, Gustavo Carlos; Tyurmin, Dmitri; et al.; Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats; Karger; Neuroendocrinology; 88; 4; 12-2008; 276-286 0028-3835 1423-0194 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/58411 |
identifier_str_mv |
Macova, Miroslava; Armando, Maria Ines; Zhou, Jin; Baiardi, Gustavo Carlos; Tyurmin, Dmitri; et al.; Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats; Karger; Neuroendocrinology; 88; 4; 12-2008; 276-286 0028-3835 1423-0194 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/FullText/150977 info:eu-repo/semantics/altIdentifier/doi/10.1159%2F000150977 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Karger |
publisher.none.fl_str_mv |
Karger |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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