Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice
- Autores
- Saavedra, Juan M.; Häuser, Walter; Ciuffo, Gladys Maria; Egidy, Giorgia; Hoe, Kwang Lae; Jöhren, Olaf; Sembonmatsu, Takaaki; Inagami, Tadashi; Armando, Inés
- Año de publicación
- 2001
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The proposed feedback between angiotensin II AT2 and AT1 receptors prompted us to study AT1 receptor expression in kidneys of male AT2 receptor-gene disrupted mice (agtr2 −/y). In wild-type (agtr2 +/y) mice, AT1 receptor binding and mRNA is abundant in glomeruli, and AT1 receptor binding is also high in the inner stripe of the outer medulla. AT2 receptors are scarce, primarily associated to cortical vascular structures. In agtr2 −/y mice, AT1 receptor binding and mRNA were increased in the kidney glomeruli, and AT1 receptor binding was higher in the rest of the cortex and outer stripe of the outer medulla, but not in its inner stripe, indicating different cellular regulation. Although AT2 receptor expression is very low in male agtr 2 +/y mice, their gene disruption alters AT1 receptor expression. AT1 upregulation alone may explain the AT2 gene-disrupted mice phenotype such as increased blood pressure, higher sensitivity to angiotensin II, and altered renal function. The indirect AT1/AT2 receptor feedback could have clinical significance because AT1antagonists are widely used in medical practice.
Fil: Saavedra, Juan M.. National Institute of Mental Health; Estados Unidos
Fil: Häuser, Walter. National Institute of Mental Health; Estados Unidos
Fil: Ciuffo, Gladys Maria. National Institute of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Egidy, Giorgia. National Institute of Mental Health; Estados Unidos
Fil: Hoe, Kwang Lae. National Institute of Mental Health; Estados Unidos
Fil: Jöhren, Olaf. National Institute of Mental Health; Estados Unidos
Fil: Sembonmatsu, Takaaki. Vanderbilt University; Estados Unidos
Fil: Inagami, Tadashi. Vanderbilt University; Estados Unidos
Fil: Armando, Inés. National Institute of Mental Health; Estados Unidos - Materia
-
Renin-angiotensin system
Angiotensin II receptors types
Gene-disrupted models - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/136383
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Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted miceSaavedra, Juan M.Häuser, WalterCiuffo, Gladys MariaEgidy, GiorgiaHoe, Kwang LaeJöhren, OlafSembonmatsu, TakaakiInagami, TadashiArmando, InésRenin-angiotensin systemAngiotensin II receptors typesGene-disrupted modelshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The proposed feedback between angiotensin II AT2 and AT1 receptors prompted us to study AT1 receptor expression in kidneys of male AT2 receptor-gene disrupted mice (agtr2 −/y). In wild-type (agtr2 +/y) mice, AT1 receptor binding and mRNA is abundant in glomeruli, and AT1 receptor binding is also high in the inner stripe of the outer medulla. AT2 receptors are scarce, primarily associated to cortical vascular structures. In agtr2 −/y mice, AT1 receptor binding and mRNA were increased in the kidney glomeruli, and AT1 receptor binding was higher in the rest of the cortex and outer stripe of the outer medulla, but not in its inner stripe, indicating different cellular regulation. Although AT2 receptor expression is very low in male agtr 2 +/y mice, their gene disruption alters AT1 receptor expression. AT1 upregulation alone may explain the AT2 gene-disrupted mice phenotype such as increased blood pressure, higher sensitivity to angiotensin II, and altered renal function. The indirect AT1/AT2 receptor feedback could have clinical significance because AT1antagonists are widely used in medical practice.Fil: Saavedra, Juan M.. National Institute of Mental Health; Estados UnidosFil: Häuser, Walter. National Institute of Mental Health; Estados UnidosFil: Ciuffo, Gladys Maria. National Institute of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Egidy, Giorgia. National Institute of Mental Health; Estados UnidosFil: Hoe, Kwang Lae. National Institute of Mental Health; Estados UnidosFil: Jöhren, Olaf. National Institute of Mental Health; Estados UnidosFil: Sembonmatsu, Takaaki. Vanderbilt University; Estados UnidosFil: Inagami, Tadashi. Vanderbilt University; Estados UnidosFil: Armando, Inés. National Institute of Mental Health; Estados UnidosAmerican Physiological Society2001-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136383Saavedra, Juan M.; Häuser, Walter; Ciuffo, Gladys Maria; Egidy, Giorgia; Hoe, Kwang Lae; et al.; Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice; American Physiological Society; American Journal Of Physiology-renal Physiology; 280; 1; 1-2001; F71-F781931-857X1522-1466CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajprenal.2001.280.1.F71info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.2001.280.1.F71info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:47Zoai:ri.conicet.gov.ar:11336/136383instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:47.851CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
title |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
spellingShingle |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice Saavedra, Juan M. Renin-angiotensin system Angiotensin II receptors types Gene-disrupted models |
title_short |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
title_full |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
title_fullStr |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
title_full_unstemmed |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
title_sort |
Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice |
dc.creator.none.fl_str_mv |
Saavedra, Juan M. Häuser, Walter Ciuffo, Gladys Maria Egidy, Giorgia Hoe, Kwang Lae Jöhren, Olaf Sembonmatsu, Takaaki Inagami, Tadashi Armando, Inés |
author |
Saavedra, Juan M. |
author_facet |
Saavedra, Juan M. Häuser, Walter Ciuffo, Gladys Maria Egidy, Giorgia Hoe, Kwang Lae Jöhren, Olaf Sembonmatsu, Takaaki Inagami, Tadashi Armando, Inés |
author_role |
author |
author2 |
Häuser, Walter Ciuffo, Gladys Maria Egidy, Giorgia Hoe, Kwang Lae Jöhren, Olaf Sembonmatsu, Takaaki Inagami, Tadashi Armando, Inés |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Renin-angiotensin system Angiotensin II receptors types Gene-disrupted models |
topic |
Renin-angiotensin system Angiotensin II receptors types Gene-disrupted models |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The proposed feedback between angiotensin II AT2 and AT1 receptors prompted us to study AT1 receptor expression in kidneys of male AT2 receptor-gene disrupted mice (agtr2 −/y). In wild-type (agtr2 +/y) mice, AT1 receptor binding and mRNA is abundant in glomeruli, and AT1 receptor binding is also high in the inner stripe of the outer medulla. AT2 receptors are scarce, primarily associated to cortical vascular structures. In agtr2 −/y mice, AT1 receptor binding and mRNA were increased in the kidney glomeruli, and AT1 receptor binding was higher in the rest of the cortex and outer stripe of the outer medulla, but not in its inner stripe, indicating different cellular regulation. Although AT2 receptor expression is very low in male agtr 2 +/y mice, their gene disruption alters AT1 receptor expression. AT1 upregulation alone may explain the AT2 gene-disrupted mice phenotype such as increased blood pressure, higher sensitivity to angiotensin II, and altered renal function. The indirect AT1/AT2 receptor feedback could have clinical significance because AT1antagonists are widely used in medical practice. Fil: Saavedra, Juan M.. National Institute of Mental Health; Estados Unidos Fil: Häuser, Walter. National Institute of Mental Health; Estados Unidos Fil: Ciuffo, Gladys Maria. National Institute of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina Fil: Egidy, Giorgia. National Institute of Mental Health; Estados Unidos Fil: Hoe, Kwang Lae. National Institute of Mental Health; Estados Unidos Fil: Jöhren, Olaf. National Institute of Mental Health; Estados Unidos Fil: Sembonmatsu, Takaaki. Vanderbilt University; Estados Unidos Fil: Inagami, Tadashi. Vanderbilt University; Estados Unidos Fil: Armando, Inés. National Institute of Mental Health; Estados Unidos |
description |
The proposed feedback between angiotensin II AT2 and AT1 receptors prompted us to study AT1 receptor expression in kidneys of male AT2 receptor-gene disrupted mice (agtr2 −/y). In wild-type (agtr2 +/y) mice, AT1 receptor binding and mRNA is abundant in glomeruli, and AT1 receptor binding is also high in the inner stripe of the outer medulla. AT2 receptors are scarce, primarily associated to cortical vascular structures. In agtr2 −/y mice, AT1 receptor binding and mRNA were increased in the kidney glomeruli, and AT1 receptor binding was higher in the rest of the cortex and outer stripe of the outer medulla, but not in its inner stripe, indicating different cellular regulation. Although AT2 receptor expression is very low in male agtr 2 +/y mice, their gene disruption alters AT1 receptor expression. AT1 upregulation alone may explain the AT2 gene-disrupted mice phenotype such as increased blood pressure, higher sensitivity to angiotensin II, and altered renal function. The indirect AT1/AT2 receptor feedback could have clinical significance because AT1antagonists are widely used in medical practice. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/136383 Saavedra, Juan M.; Häuser, Walter; Ciuffo, Gladys Maria; Egidy, Giorgia; Hoe, Kwang Lae; et al.; Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice; American Physiological Society; American Journal Of Physiology-renal Physiology; 280; 1; 1-2001; F71-F78 1931-857X 1522-1466 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/136383 |
identifier_str_mv |
Saavedra, Juan M.; Häuser, Walter; Ciuffo, Gladys Maria; Egidy, Giorgia; Hoe, Kwang Lae; et al.; Increased AT 1 receptor expression and mRNA in kidney glomeruli of AT 2 receptor gene-disrupted mice; American Physiological Society; American Journal Of Physiology-renal Physiology; 280; 1; 1-2001; F71-F78 1931-857X 1522-1466 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.physiology.org/doi/full/10.1152/ajprenal.2001.280.1.F71 info:eu-repo/semantics/altIdentifier/doi/10.1152/ajprenal.2001.280.1.F71 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society |
publisher.none.fl_str_mv |
American Physiological Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |