Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat

Autores
Baiardi, Gustavo Carlos; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; Saavedra, Juan M.
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant differences between males and females. AT 2 receptor expression was restricted in female rats to the capsule, the transition zone between outer and inner medulla, the endothelium lining the papilla, and arcuate arteries and veins. There were no AT2 receptors in male rats, while male mice express substantial numbers of estrogen-dependent AT2 receptors. Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only. AT 1 receptor and AT2 receptor expression were estrogen-dependent, with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats. Estrogen treatment increased prostaglandin E2 (PGE2) and cGMP concentrations in the renal medulla, and eNOS expression in cortical arteries. In rodents, expression of renal Angiotensin II receptor types is estrogen-dependent, with significant species, strain and area differences. Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney. © 2004 Published by Elsevier B.V.
Fil: Baiardi, Gustavo Carlos. National Institute Of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Macova, Miroslava. National Institute Of Mental Health; Estados Unidos
Fil: Armando, Ines. National Institute Of Mental Health; Estados Unidos
Fil: Ando, Hiromichi. National Institute Of Mental Health; Estados Unidos
Fil: Tyurmin, Dmitri. National Institute Of Mental Health; Estados Unidos
Fil: Saavedra, Juan M.. National Institute Of Mental Health; Estados Unidos
Materia
KIDNEY FUNCTION
OVARIAN HORMONES
PROSTAGLANDINS
RENIN-ANGIOTENSIN SYSTEM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/114982
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/114982
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the ratBaiardi, Gustavo CarlosMacova, MiroslavaArmando, InesAndo, HiromichiTyurmin, DmitriSaavedra, Juan M.KIDNEY FUNCTIONOVARIAN HORMONESPROSTAGLANDINSRENIN-ANGIOTENSIN SYSTEMhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant differences between males and females. AT 2 receptor expression was restricted in female rats to the capsule, the transition zone between outer and inner medulla, the endothelium lining the papilla, and arcuate arteries and veins. There were no AT2 receptors in male rats, while male mice express substantial numbers of estrogen-dependent AT2 receptors. Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only. AT 1 receptor and AT2 receptor expression were estrogen-dependent, with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats. Estrogen treatment increased prostaglandin E2 (PGE2) and cGMP concentrations in the renal medulla, and eNOS expression in cortical arteries. In rodents, expression of renal Angiotensin II receptor types is estrogen-dependent, with significant species, strain and area differences. Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney. © 2004 Published by Elsevier B.V.Fil: Baiardi, Gustavo Carlos. National Institute Of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Macova, Miroslava. National Institute Of Mental Health; Estados UnidosFil: Armando, Ines. National Institute Of Mental Health; Estados UnidosFil: Ando, Hiromichi. National Institute Of Mental Health; Estados UnidosFil: Tyurmin, Dmitri. National Institute Of Mental Health; Estados UnidosFil: Saavedra, Juan M.. National Institute Of Mental Health; Estados UnidosElsevier Science2004-09-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114982Baiardi, Gustavo Carlos; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; et al.; Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat; Elsevier Science; Regulatory Peptides; 124; 1-3; 22-9-2004; 7-170167-0115CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.regpep.2004.06.021info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0167011504002113info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:03Zoai:ri.conicet.gov.ar:11336/114982instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:03.971CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
title Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
spellingShingle Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
Baiardi, Gustavo Carlos
KIDNEY FUNCTION
OVARIAN HORMONES
PROSTAGLANDINS
RENIN-ANGIOTENSIN SYSTEM
title_short Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
title_full Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
title_fullStr Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
title_full_unstemmed Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
title_sort Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat
dc.creator.none.fl_str_mv Baiardi, Gustavo Carlos
Macova, Miroslava
Armando, Ines
Ando, Hiromichi
Tyurmin, Dmitri
Saavedra, Juan M.
author Baiardi, Gustavo Carlos
author_facet Baiardi, Gustavo Carlos
Macova, Miroslava
Armando, Ines
Ando, Hiromichi
Tyurmin, Dmitri
Saavedra, Juan M.
author_role author
author2 Macova, Miroslava
Armando, Ines
Ando, Hiromichi
Tyurmin, Dmitri
Saavedra, Juan M.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv KIDNEY FUNCTION
OVARIAN HORMONES
PROSTAGLANDINS
RENIN-ANGIOTENSIN SYSTEM
topic KIDNEY FUNCTION
OVARIAN HORMONES
PROSTAGLANDINS
RENIN-ANGIOTENSIN SYSTEM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant differences between males and females. AT 2 receptor expression was restricted in female rats to the capsule, the transition zone between outer and inner medulla, the endothelium lining the papilla, and arcuate arteries and veins. There were no AT2 receptors in male rats, while male mice express substantial numbers of estrogen-dependent AT2 receptors. Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only. AT 1 receptor and AT2 receptor expression were estrogen-dependent, with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats. Estrogen treatment increased prostaglandin E2 (PGE2) and cGMP concentrations in the renal medulla, and eNOS expression in cortical arteries. In rodents, expression of renal Angiotensin II receptor types is estrogen-dependent, with significant species, strain and area differences. Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney. © 2004 Published by Elsevier B.V.
Fil: Baiardi, Gustavo Carlos. National Institute Of Mental Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Macova, Miroslava. National Institute Of Mental Health; Estados Unidos
Fil: Armando, Ines. National Institute Of Mental Health; Estados Unidos
Fil: Ando, Hiromichi. National Institute Of Mental Health; Estados Unidos
Fil: Tyurmin, Dmitri. National Institute Of Mental Health; Estados Unidos
Fil: Saavedra, Juan M.. National Institute Of Mental Health; Estados Unidos
description We studied renal AT1 and AT2 receptors in male, female, ovariectomized and ovariectomized-estrogen-treated Wistar-Hanover and Wistar-Kyoto rats. AT1 receptors and AT1A receptor mRNA predominated, with no significant differences between males and females. AT 2 receptor expression was restricted in female rats to the capsule, the transition zone between outer and inner medulla, the endothelium lining the papilla, and arcuate arteries and veins. There were no AT2 receptors in male rats, while male mice express substantial numbers of estrogen-dependent AT2 receptors. Arcuate arteries and veins expressed AT1B mRNA in males and females, and AT2 mRNA in females only. AT 1 receptor and AT2 receptor expression were estrogen-dependent, with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats. Estrogen treatment increased prostaglandin E2 (PGE2) and cGMP concentrations in the renal medulla, and eNOS expression in cortical arteries. In rodents, expression of renal Angiotensin II receptor types is estrogen-dependent, with significant species, strain and area differences. Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney. © 2004 Published by Elsevier B.V.
publishDate 2004
dc.date.none.fl_str_mv 2004-09-22
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/114982
Baiardi, Gustavo Carlos; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; et al.; Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat; Elsevier Science; Regulatory Peptides; 124; 1-3; 22-9-2004; 7-17
0167-0115
CONICET Digital
CONICET
url http://hdl.handle.net/11336/114982
identifier_str_mv Baiardi, Gustavo Carlos; Macova, Miroslava; Armando, Ines; Ando, Hiromichi; Tyurmin, Dmitri; et al.; Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat; Elsevier Science; Regulatory Peptides; 124; 1-3; 22-9-2004; 7-17
0167-0115
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.regpep.2004.06.021
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0167011504002113
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269321263316992
score 13.13397

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