Early detection of intentional harm in the human amygdala

Autores
Hesse Rizzi, Eugenia Fátima; Mikulan, Ezequiel Pablo; Decety, Jean; Sigman, Mariano; Del Carmen Garcia, María; Silva, Walter; Ciraolo, Carlos; Vaucheret, Esteban; Baglivo, Fabricio; Huepe, David; Lopez, Vladimir; Manes, Facundo Francisco; Bekinschtein, Tristán Andrés; Ibañez, Agustin Mariano
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.
Fil: Hesse Rizzi, Eugenia Fátima. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Mikulan, Ezequiel Pablo. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Decety, Jean. University of Chicago; Estados Unidos
Fil: Sigman, Mariano. Universidad de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Del Carmen Garcia, María. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Silva, Walter. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Ciraolo, Carlos. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Vaucheret, Esteban. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Baglivo, Fabricio. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; Argentina
Fil: Huepe, David. Universidad Diego Portales; Chile
Fil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile
Fil: Manes, Facundo Francisco. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido
Fil: Ibañez, Agustin Mariano. Universidad Diego Portales; Chile. Universidad Autonoma del Caribe; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Materia
Amygdala
Intentional Harm
Intracranial Recordings
Moral Cognition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38696
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Early detection of intentional harm in the human amygdalaHesse Rizzi, Eugenia FátimaMikulan, Ezequiel PabloDecety, JeanSigman, MarianoDel Carmen Garcia, MaríaSilva, WalterCiraolo, CarlosVaucheret, EstebanBaglivo, FabricioHuepe, DavidLopez, VladimirManes, Facundo FranciscoBekinschtein, Tristán AndrésIbañez, Agustin MarianoAmygdalaIntentional HarmIntracranial RecordingsMoral Cognitionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.Fil: Hesse Rizzi, Eugenia Fátima. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Mikulan, Ezequiel Pablo. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Decety, Jean. University of Chicago; Estados UnidosFil: Sigman, Mariano. Universidad de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Del Carmen Garcia, María. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Silva, Walter. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Ciraolo, Carlos. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Vaucheret, Esteban. Hospital Italiano. Instituto Universitario - Escuela de Medicina; ArgentinaFil: Baglivo, Fabricio. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; ArgentinaFil: Huepe, David. Universidad Diego Portales; ChileFil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; ChileFil: Manes, Facundo Francisco. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Ibañez, Agustin Mariano. Universidad Diego Portales; Chile. Universidad Autonoma del Caribe; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaOxford University Press2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38696Hesse Rizzi, Eugenia Fátima; Mikulan, Ezequiel Pablo; Decety, Jean; Sigman, Mariano; Del Carmen Garcia, María; et al.; Early detection of intentional harm in the human amygdala; Oxford University Press; Brain; 139; 1; 1-2016; 54-610006-8950CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awv336info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article/139/1/54/2468818info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:05Zoai:ri.conicet.gov.ar:11336/38696instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:05.991CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Early detection of intentional harm in the human amygdala
title Early detection of intentional harm in the human amygdala
spellingShingle Early detection of intentional harm in the human amygdala
Hesse Rizzi, Eugenia Fátima
Amygdala
Intentional Harm
Intracranial Recordings
Moral Cognition
title_short Early detection of intentional harm in the human amygdala
title_full Early detection of intentional harm in the human amygdala
title_fullStr Early detection of intentional harm in the human amygdala
title_full_unstemmed Early detection of intentional harm in the human amygdala
title_sort Early detection of intentional harm in the human amygdala
dc.creator.none.fl_str_mv Hesse Rizzi, Eugenia Fátima
Mikulan, Ezequiel Pablo
Decety, Jean
Sigman, Mariano
Del Carmen Garcia, María
Silva, Walter
Ciraolo, Carlos
Vaucheret, Esteban
Baglivo, Fabricio
Huepe, David
Lopez, Vladimir
Manes, Facundo Francisco
Bekinschtein, Tristán Andrés
Ibañez, Agustin Mariano
author Hesse Rizzi, Eugenia Fátima
author_facet Hesse Rizzi, Eugenia Fátima
Mikulan, Ezequiel Pablo
Decety, Jean
Sigman, Mariano
Del Carmen Garcia, María
Silva, Walter
Ciraolo, Carlos
Vaucheret, Esteban
Baglivo, Fabricio
Huepe, David
Lopez, Vladimir
Manes, Facundo Francisco
Bekinschtein, Tristán Andrés
Ibañez, Agustin Mariano
author_role author
author2 Mikulan, Ezequiel Pablo
Decety, Jean
Sigman, Mariano
Del Carmen Garcia, María
Silva, Walter
Ciraolo, Carlos
Vaucheret, Esteban
Baglivo, Fabricio
Huepe, David
Lopez, Vladimir
Manes, Facundo Francisco
Bekinschtein, Tristán Andrés
Ibañez, Agustin Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Amygdala
Intentional Harm
Intracranial Recordings
Moral Cognition
topic Amygdala
Intentional Harm
Intracranial Recordings
Moral Cognition
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.
Fil: Hesse Rizzi, Eugenia Fátima. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Mikulan, Ezequiel Pablo. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Decety, Jean. University of Chicago; Estados Unidos
Fil: Sigman, Mariano. Universidad de Buenos Aires; Argentina. Universidad Torcuato Di Tella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Del Carmen Garcia, María. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Silva, Walter. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Ciraolo, Carlos. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Vaucheret, Esteban. Hospital Italiano. Instituto Universitario - Escuela de Medicina; Argentina
Fil: Baglivo, Fabricio. Universidad Favaloro; Argentina. Universidad de Buenos Aires; Argentina. Universidad Diego Portales; Chile. Instituto de Neurología Cognitiva; Argentina
Fil: Huepe, David. Universidad Diego Portales; Chile
Fil: Lopez, Vladimir. Pontificia Universidad Católica de Chile; Chile
Fil: Manes, Facundo Francisco. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido
Fil: Ibañez, Agustin Mariano. Universidad Diego Portales; Chile. Universidad Autonoma del Caribe; Colombia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
description A decisive element of moral cognition is the detection of harm and its assessment as intentional or unintentional. Moral cognition engages brain networks supporting mentalizing, intentionality, empathic concern and evaluation. These networks rely on the amygdala as a critical hub, likely through frontotemporal connections indexing stimulus salience. We assessed inferences about perceived harm using a paradigm validated through functional magnetic resonance imaging, eye-tracking and electroencephalogram recordings. During the task, we measured local field potentials in three patients with depth electrodes (n = 115) placed in the amygdala and in several frontal, temporal, and parietal locations. Direct electrophysiological recordings demonstrate that intentional harm induces early activity in the amygdala (5 200 ms), which-in turn-predicts intention attribution. The amygdala was the only site that systematically discriminated between critical conditions and predicted their classification of events as intentional. Moreover, connectivity analysis showed that intentional harm induced stronger frontotemporal information sharing at early stages. Results support the 'many roads' view of the amygdala and highlight its role in the rapid encoding of intention and salience-critical components of mentalizing and moral evaluation.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38696
Hesse Rizzi, Eugenia Fátima; Mikulan, Ezequiel Pablo; Decety, Jean; Sigman, Mariano; Del Carmen Garcia, María; et al.; Early detection of intentional harm in the human amygdala; Oxford University Press; Brain; 139; 1; 1-2016; 54-61
0006-8950
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38696
identifier_str_mv Hesse Rizzi, Eugenia Fátima; Mikulan, Ezequiel Pablo; Decety, Jean; Sigman, Mariano; Del Carmen Garcia, María; et al.; Early detection of intentional harm in the human amygdala; Oxford University Press; Brain; 139; 1; 1-2016; 54-61
0006-8950
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1093/brain/awv336
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/brain/article/139/1/54/2468818
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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