Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
- Autores
- Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; Manes, Facundo Francisco; Ibáñez Barassi, Agustín Mariano
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.
Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Morales, Juan Pablo. Universidad Diego Portales; Chile
Fil: Slachevsky, Andrea. Universidad de Chile; Chile
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; Chile
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; Australia
Fil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia - Materia
-
Bvftd
Empathy
Gray Matter Atrophy
Intentional Harm
Intentionality Comprehension
Moral Judgment - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/38737
Ver los metadatos del registro completo
id |
CONICETDig_200f1dcc1bd85a903222e320040868f5 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/38737 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementiaBáez Buitrago, Sandra JimenaMorales, Juan PabloSlachevsky, AndreaTorralva, TeresaMatus, CristianManes, Facundo FranciscoIbáñez Barassi, Agustín MarianoBvftdEmpathyGray Matter AtrophyIntentional HarmIntentionality ComprehensionMoral Judgmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Morales, Juan Pablo. Universidad Diego Portales; ChileFil: Slachevsky, Andrea. Universidad de Chile; ChileFil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; ChileFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; AustraliaFil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; ColombiaElsevier Masson2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38737Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-320010-9452CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.11.007info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945215003858info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:00Zoai:ri.conicet.gov.ar:11336/38737instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:01.117CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
title |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
spellingShingle |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia Báez Buitrago, Sandra Jimena Bvftd Empathy Gray Matter Atrophy Intentional Harm Intentionality Comprehension Moral Judgment |
title_short |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
title_full |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
title_fullStr |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
title_full_unstemmed |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
title_sort |
Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia |
dc.creator.none.fl_str_mv |
Báez Buitrago, Sandra Jimena Morales, Juan Pablo Slachevsky, Andrea Torralva, Teresa Matus, Cristian Manes, Facundo Francisco Ibáñez Barassi, Agustín Mariano |
author |
Báez Buitrago, Sandra Jimena |
author_facet |
Báez Buitrago, Sandra Jimena Morales, Juan Pablo Slachevsky, Andrea Torralva, Teresa Matus, Cristian Manes, Facundo Francisco Ibáñez Barassi, Agustín Mariano |
author_role |
author |
author2 |
Morales, Juan Pablo Slachevsky, Andrea Torralva, Teresa Matus, Cristian Manes, Facundo Francisco Ibáñez Barassi, Agustín Mariano |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Bvftd Empathy Gray Matter Atrophy Intentional Harm Intentionality Comprehension Moral Judgment |
topic |
Bvftd Empathy Gray Matter Atrophy Intentional Harm Intentionality Comprehension Moral Judgment |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications. Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina Fil: Morales, Juan Pablo. Universidad Diego Portales; Chile Fil: Slachevsky, Andrea. Universidad de Chile; Chile Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile Fil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; Chile Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; Australia Fil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia |
description |
Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/38737 Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-32 0010-9452 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/38737 |
identifier_str_mv |
Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-32 0010-9452 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.11.007 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945215003858 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Masson |
publisher.none.fl_str_mv |
Elsevier Masson |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269730651504640 |
score |
13.13397 |