Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia

Autores
Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; Manes, Facundo Francisco; Ibáñez Barassi, Agustín Mariano
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.
Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Morales, Juan Pablo. Universidad Diego Portales; Chile
Fil: Slachevsky, Andrea. Universidad de Chile; Chile
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; Chile
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; Australia
Fil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia
Materia
Bvftd
Empathy
Gray Matter Atrophy
Intentional Harm
Intentionality Comprehension
Moral Judgment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/38737
Acceder
id CONICETDig_200f1dcc1bd85a903222e320040868f5
oai_identifier_str oai:ri.conicet.gov.ar:11336/38737
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementiaBáez Buitrago, Sandra JimenaMorales, Juan PabloSlachevsky, AndreaTorralva, TeresaMatus, CristianManes, Facundo FranciscoIbáñez Barassi, Agustín MarianoBvftdEmpathyGray Matter AtrophyIntentional HarmIntentionality ComprehensionMoral Judgmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Morales, Juan Pablo. Universidad Diego Portales; ChileFil: Slachevsky, Andrea. Universidad de Chile; ChileFil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; ChileFil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; ChileFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; AustraliaFil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; ColombiaElsevier Masson2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38737Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-320010-9452CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.11.007info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945215003858info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:54Zoai:ri.conicet.gov.ar:11336/38737instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:54.431CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
title Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
spellingShingle Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
Báez Buitrago, Sandra Jimena
Bvftd
Empathy
Gray Matter Atrophy
Intentional Harm
Intentionality Comprehension
Moral Judgment
title_short Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
title_full Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
title_fullStr Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
title_full_unstemmed Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
title_sort Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia
dc.creator.none.fl_str_mv Báez Buitrago, Sandra Jimena
Morales, Juan Pablo
Slachevsky, Andrea
Torralva, Teresa
Matus, Cristian
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author Báez Buitrago, Sandra Jimena
author_facet Báez Buitrago, Sandra Jimena
Morales, Juan Pablo
Slachevsky, Andrea
Torralva, Teresa
Matus, Cristian
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author_role author
author2 Morales, Juan Pablo
Slachevsky, Andrea
Torralva, Teresa
Matus, Cristian
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Bvftd
Empathy
Gray Matter Atrophy
Intentional Harm
Intentionality Comprehension
Moral Judgment
topic Bvftd
Empathy
Gray Matter Atrophy
Intentional Harm
Intentionality Comprehension
Moral Judgment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.
Fil: Báez Buitrago, Sandra Jimena. Universidad Diego Portales; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina
Fil: Morales, Juan Pablo. Universidad Diego Portales; Chile
Fil: Slachevsky, Andrea. Universidad de Chile; Chile
Fil: Torralva, Teresa. Instituto de Neurología Cognitiva; Argentina. Universidad Diego Portales; Chile
Fil: Matus, Cristian. Fundación Médica San Cristobal; Chile. Hospital de Carabineros de Chile; Chile
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Macquarie University; Australia
Fil: Ibáñez Barassi, Agustín Mariano. Macquarie University; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Diego Portales; Chile. Universidad Autónoma del Caribe; Colombia
description Perceiving and evaluating intentional harms in an interpersonal context engages both cognitive and emotional domains. This process involves inference of intentions, moral judgment, and, crucially, empathy towards others' suffering. This latter skill is notably impaired in behavioral variant frontotemporal dementia (bvFTD). However, the relationship between regional brain atrophy in bvFTD and deficits in the above-mentioned abilities is not well understood. The present study investigated how gray matter (GM) atrophy in bvFTD patients correlates with the perception and evaluation of harmful actions (attribution of intentionality, evaluation of harmful behavior, empathic concern, and moral judgment). First, we compared the behavioral performance of 26 bvFTD patients and 23 healthy controls on an experimental task (ET) indexing intentionality, empathy, and moral cognition during evaluation of harmful actions. Second, we compared GM volume in patients and controls using voxel-based morphometry (VBM). Third, we examined brain regions where atrophy might be associated with specific impairments in the patient group. Finally, we explored whether the patients' deficits in intentionality comprehension and empathic concern could be partially explained by regional GM atrophy or impairments in other relevant factors, such as executive functions (EFs). In bvFTD patients, atrophy of limbic structures (amygdala and anterior paracingulate cortex - APC) was related to impairments in intentionality comprehension, while atrophy of the orbitofrontal cortex (OFC) was associated with empathic concern deficits. Intentionality comprehension impairments were predicted by EFs and orbitofrontal atrophy predicted deficits in empathic concern. Thus, although the perception and evaluation of harmful actions are variously compromised in bvFTD, deficits in empathic concern may be central to this syndrome as they are associated with one of the earliest atrophied region. More generally, our results shed light on social cognition deficits in bvFTD and may have important clinical implications.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/38737
Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-32
0010-9452
CONICET Digital
CONICET
url http://hdl.handle.net/11336/38737
identifier_str_mv Báez Buitrago, Sandra Jimena; Morales, Juan Pablo; Slachevsky, Andrea; Torralva, Teresa; Matus, Cristian; et al.; Orbitofrontal and limbic signatures of empathic concern and intentional harm in the behavioral variant frontotemporal dementia; Elsevier Masson; Cortex; 75; 2-2016; 20-32
0010-9452
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cortex.2015.11.007
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010945215003858
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Masson
publisher.none.fl_str_mv Elsevier Masson
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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