New developments in nucleoside analogues biosynthesis: A review

Autores
Lapponi, María José; Rivero, Cintia Wanda; Zinni, Maria Alejandra; Britos, Claudia Noelia; Trelles, Jorge Abel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present review deals with current advances in the chemoenzymatic synthesis of biologically important nucleoside analogues (NA), either by the use of microorganisms or enzymes as biocatalysts. The interest in exploiting these biocatalysts is constantly increasing nowadays because of the advantages they have with respect to classic organic chemistry synthesis, such as a fewer number of synthesis steps, an improved chemo-, regio- and stereoselectivity, high catalytic efficiency, and simple subsequent processing. Besides, this technology offers an environmentally friendly alternative in comparison with synthetic chemistry. Thus, the present article gives a brief outline of emerging methodologies for the biosynthesis of NAs commonly used in cancer therapies, such as cladribine, clofarabine, nelarabine, fludarabine, decitabine, cytarabine and floxuridine, and as antivirals: ribavirin, iduviran, vidarabine, acyclovir, lamivudine and emtricitabine from microbial or enzymatic sources, and their potential applications in the biotechnology industry. Also, it points highlights the importance of subsequent modifications of nucleoside analogues by different enzymes used as biocatalysts in order to improve the pharmacological properties of the existing drugs. Moreover, the importance of biocatalyst immobilization for industrial applications is considered.
Fil: Lapponi, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rivero, Cintia Wanda. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zinni, Maria Alejandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina
Fil: Britos, Claudia Noelia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trelles, Jorge Abel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTITUMOR AGENT
ANTIVIRAL COMPOUND
GREEN CHEMISTRY
IMMOBILIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117439
Acceder
id CONICETDig_d5062e3636f9f36d2578dddd7354962c
oai_identifier_str oai:ri.conicet.gov.ar:11336/117439
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling New developments in nucleoside analogues biosynthesis: A reviewLapponi, María JoséRivero, Cintia WandaZinni, Maria AlejandraBritos, Claudia NoeliaTrelles, Jorge AbelANTITUMOR AGENTANTIVIRAL COMPOUNDGREEN CHEMISTRYIMMOBILIZATIONhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2The present review deals with current advances in the chemoenzymatic synthesis of biologically important nucleoside analogues (NA), either by the use of microorganisms or enzymes as biocatalysts. The interest in exploiting these biocatalysts is constantly increasing nowadays because of the advantages they have with respect to classic organic chemistry synthesis, such as a fewer number of synthesis steps, an improved chemo-, regio- and stereoselectivity, high catalytic efficiency, and simple subsequent processing. Besides, this technology offers an environmentally friendly alternative in comparison with synthetic chemistry. Thus, the present article gives a brief outline of emerging methodologies for the biosynthesis of NAs commonly used in cancer therapies, such as cladribine, clofarabine, nelarabine, fludarabine, decitabine, cytarabine and floxuridine, and as antivirals: ribavirin, iduviran, vidarabine, acyclovir, lamivudine and emtricitabine from microbial or enzymatic sources, and their potential applications in the biotechnology industry. Also, it points highlights the importance of subsequent modifications of nucleoside analogues by different enzymes used as biocatalysts in order to improve the pharmacological properties of the existing drugs. Moreover, the importance of biocatalyst immobilization for industrial applications is considered.Fil: Lapponi, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rivero, Cintia Wanda. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zinni, Maria Alejandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; ArgentinaFil: Britos, Claudia Noelia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Trelles, Jorge Abel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science2016-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117439Lapponi, María José; Rivero, Cintia Wanda; Zinni, Maria Alejandra; Britos, Claudia Noelia; Trelles, Jorge Abel; New developments in nucleoside analogues biosynthesis: A review; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 133; 11-2016; 218-2331381-1177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2016.08.015info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S138111771630159Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:05Zoai:ri.conicet.gov.ar:11336/117439instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:06.115CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv New developments in nucleoside analogues biosynthesis: A review
title New developments in nucleoside analogues biosynthesis: A review
spellingShingle New developments in nucleoside analogues biosynthesis: A review
Lapponi, María José
ANTITUMOR AGENT
ANTIVIRAL COMPOUND
GREEN CHEMISTRY
IMMOBILIZATION
title_short New developments in nucleoside analogues biosynthesis: A review
title_full New developments in nucleoside analogues biosynthesis: A review
title_fullStr New developments in nucleoside analogues biosynthesis: A review
title_full_unstemmed New developments in nucleoside analogues biosynthesis: A review
title_sort New developments in nucleoside analogues biosynthesis: A review
dc.creator.none.fl_str_mv Lapponi, María José
Rivero, Cintia Wanda
Zinni, Maria Alejandra
Britos, Claudia Noelia
Trelles, Jorge Abel
author Lapponi, María José
author_facet Lapponi, María José
Rivero, Cintia Wanda
Zinni, Maria Alejandra
Britos, Claudia Noelia
Trelles, Jorge Abel
author_role author
author2 Rivero, Cintia Wanda
Zinni, Maria Alejandra
Britos, Claudia Noelia
Trelles, Jorge Abel
author2_role author
author
author
author
dc.subject.none.fl_str_mv ANTITUMOR AGENT
ANTIVIRAL COMPOUND
GREEN CHEMISTRY
IMMOBILIZATION
topic ANTITUMOR AGENT
ANTIVIRAL COMPOUND
GREEN CHEMISTRY
IMMOBILIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The present review deals with current advances in the chemoenzymatic synthesis of biologically important nucleoside analogues (NA), either by the use of microorganisms or enzymes as biocatalysts. The interest in exploiting these biocatalysts is constantly increasing nowadays because of the advantages they have with respect to classic organic chemistry synthesis, such as a fewer number of synthesis steps, an improved chemo-, regio- and stereoselectivity, high catalytic efficiency, and simple subsequent processing. Besides, this technology offers an environmentally friendly alternative in comparison with synthetic chemistry. Thus, the present article gives a brief outline of emerging methodologies for the biosynthesis of NAs commonly used in cancer therapies, such as cladribine, clofarabine, nelarabine, fludarabine, decitabine, cytarabine and floxuridine, and as antivirals: ribavirin, iduviran, vidarabine, acyclovir, lamivudine and emtricitabine from microbial or enzymatic sources, and their potential applications in the biotechnology industry. Also, it points highlights the importance of subsequent modifications of nucleoside analogues by different enzymes used as biocatalysts in order to improve the pharmacological properties of the existing drugs. Moreover, the importance of biocatalyst immobilization for industrial applications is considered.
Fil: Lapponi, María José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Rivero, Cintia Wanda. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zinni, Maria Alejandra. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina
Fil: Britos, Claudia Noelia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trelles, Jorge Abel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Investigación en Biotecnología Sustentable; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The present review deals with current advances in the chemoenzymatic synthesis of biologically important nucleoside analogues (NA), either by the use of microorganisms or enzymes as biocatalysts. The interest in exploiting these biocatalysts is constantly increasing nowadays because of the advantages they have with respect to classic organic chemistry synthesis, such as a fewer number of synthesis steps, an improved chemo-, regio- and stereoselectivity, high catalytic efficiency, and simple subsequent processing. Besides, this technology offers an environmentally friendly alternative in comparison with synthetic chemistry. Thus, the present article gives a brief outline of emerging methodologies for the biosynthesis of NAs commonly used in cancer therapies, such as cladribine, clofarabine, nelarabine, fludarabine, decitabine, cytarabine and floxuridine, and as antivirals: ribavirin, iduviran, vidarabine, acyclovir, lamivudine and emtricitabine from microbial or enzymatic sources, and their potential applications in the biotechnology industry. Also, it points highlights the importance of subsequent modifications of nucleoside analogues by different enzymes used as biocatalysts in order to improve the pharmacological properties of the existing drugs. Moreover, the importance of biocatalyst immobilization for industrial applications is considered.
publishDate 2016
dc.date.none.fl_str_mv 2016-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117439
Lapponi, María José; Rivero, Cintia Wanda; Zinni, Maria Alejandra; Britos, Claudia Noelia; Trelles, Jorge Abel; New developments in nucleoside analogues biosynthesis: A review; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 133; 11-2016; 218-233
1381-1177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117439
identifier_str_mv Lapponi, María José; Rivero, Cintia Wanda; Zinni, Maria Alejandra; Britos, Claudia Noelia; Trelles, Jorge Abel; New developments in nucleoside analogues biosynthesis: A review; Elsevier Science; Journal of Molecular Catalysis B: Enzymatic; 133; 11-2016; 218-233
1381-1177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2016.08.015
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S138111771630159X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082841196101632
score 13.22299

Publicaciones similares