Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium

Autores
Zanetti, Samanta Romina; Aveldaño, Marta Isabel
Año de publicación
2008
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Because it selectively damages testicular capillary endothelial cells, exposure to cadmium results in hemorrhagic ischemia and hemato-testicular barrier disruption. Tight junctions between Sertoli cells are disassembled, followed by sloughing of dead Sertoli and germ cells to seminiferous tubule lumen. Here we studied the early and late effects of CdCl on rat testicular lipids. 2 The early effects were similar to those of ischemia induced by testicular artery ligation. Two days after a single CdCl dose, visible 2 hemorrhage and inflammatory edema was accompanied by a massive hydrolysis of germ cell 22:5-rich glycerophospholipids (GPL) (to free fatty acids and diacylglycerols), and of sphingomyelins (SM) containing normal and hydroxylated polyenoic fatty acids (to the corresponding ceramides, Cer). Thirty and 45 days later, the testicular weight was reduced to less than one third and most of the original 22:5-GPL and their products had been removed from the testis. Cholesterol esters and triglycerides mirrored the GPL changes, suggesting they were formed as GPL fatty acids were eliminated, probably by phagocytes. By contrast, the Cer initially produced remained high and unchanged in the tissue. Whether this is due to physical seclusion of Cer in a space inaccessible to phagocytes or to a Cd-related inhibition of ceramidase remains to be established
Fil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Aveldaño, Marta Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Córdoba
Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos
Materia
CADMIUM
NECROSIS
APOPTOSIS
GERM CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/235762
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/235762
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To CadmiumZanetti, Samanta RominaAveldaño, Marta IsabelCADMIUMNECROSISAPOPTOSISGERM CELLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Because it selectively damages testicular capillary endothelial cells, exposure to cadmium results in hemorrhagic ischemia and hemato-testicular barrier disruption. Tight junctions between Sertoli cells are disassembled, followed by sloughing of dead Sertoli and germ cells to seminiferous tubule lumen. Here we studied the early and late effects of CdCl on rat testicular lipids. 2 The early effects were similar to those of ischemia induced by testicular artery ligation. Two days after a single CdCl dose, visible 2 hemorrhage and inflammatory edema was accompanied by a massive hydrolysis of germ cell 22:5-rich glycerophospholipids (GPL) (to free fatty acids and diacylglycerols), and of sphingomyelins (SM) containing normal and hydroxylated polyenoic fatty acids (to the corresponding ceramides, Cer). Thirty and 45 days later, the testicular weight was reduced to less than one third and most of the original 22:5-GPL and their products had been removed from the testis. Cholesterol esters and triglycerides mirrored the GPL changes, suggesting they were formed as GPL fatty acids were eliminated, probably by phagocytes. By contrast, the Cer initially produced remained high and unchanged in the tissue. Whether this is due to physical seclusion of Cer in a space inaccessible to phagocytes or to a Cd-related inhibition of ceramidase remains to be establishedFil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaFil: Aveldaño, Marta Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; ArgentinaXLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología MolecularCórdobaArgentinaSociedad Argentina de Investigación en Bioquímica y Biología MolecularUniversidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. BurgosUniversidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos2008info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/235762Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium; XLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; Córdoba; Argentina; 2008; 92-920327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://newsite.saib.org.ar/publicaciones/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:53:54Zoai:ri.conicet.gov.ar:11336/235762instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:53:54.561CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
title Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
spellingShingle Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
Zanetti, Samanta Romina
CADMIUM
NECROSIS
APOPTOSIS
GERM CELLS
title_short Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
title_full Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
title_fullStr Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
title_full_unstemmed Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
title_sort Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium
dc.creator.none.fl_str_mv Zanetti, Samanta Romina
Aveldaño, Marta Isabel
author Zanetti, Samanta Romina
author_facet Zanetti, Samanta Romina
Aveldaño, Marta Isabel
author_role author
author2 Aveldaño, Marta Isabel
author2_role author
dc.subject.none.fl_str_mv CADMIUM
NECROSIS
APOPTOSIS
GERM CELLS
topic CADMIUM
NECROSIS
APOPTOSIS
GERM CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Because it selectively damages testicular capillary endothelial cells, exposure to cadmium results in hemorrhagic ischemia and hemato-testicular barrier disruption. Tight junctions between Sertoli cells are disassembled, followed by sloughing of dead Sertoli and germ cells to seminiferous tubule lumen. Here we studied the early and late effects of CdCl on rat testicular lipids. 2 The early effects were similar to those of ischemia induced by testicular artery ligation. Two days after a single CdCl dose, visible 2 hemorrhage and inflammatory edema was accompanied by a massive hydrolysis of germ cell 22:5-rich glycerophospholipids (GPL) (to free fatty acids and diacylglycerols), and of sphingomyelins (SM) containing normal and hydroxylated polyenoic fatty acids (to the corresponding ceramides, Cer). Thirty and 45 days later, the testicular weight was reduced to less than one third and most of the original 22:5-GPL and their products had been removed from the testis. Cholesterol esters and triglycerides mirrored the GPL changes, suggesting they were formed as GPL fatty acids were eliminated, probably by phagocytes. By contrast, the Cer initially produced remained high and unchanged in the tissue. Whether this is due to physical seclusion of Cer in a space inaccessible to phagocytes or to a Cd-related inhibition of ceramidase remains to be established
Fil: Zanetti, Samanta Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
Fil: Aveldaño, Marta Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina
XLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Córdoba
Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos
description Because it selectively damages testicular capillary endothelial cells, exposure to cadmium results in hemorrhagic ischemia and hemato-testicular barrier disruption. Tight junctions between Sertoli cells are disassembled, followed by sloughing of dead Sertoli and germ cells to seminiferous tubule lumen. Here we studied the early and late effects of CdCl on rat testicular lipids. 2 The early effects were similar to those of ischemia induced by testicular artery ligation. Two days after a single CdCl dose, visible 2 hemorrhage and inflammatory edema was accompanied by a massive hydrolysis of germ cell 22:5-rich glycerophospholipids (GPL) (to free fatty acids and diacylglycerols), and of sphingomyelins (SM) containing normal and hydroxylated polyenoic fatty acids (to the corresponding ceramides, Cer). Thirty and 45 days later, the testicular weight was reduced to less than one third and most of the original 22:5-GPL and their products had been removed from the testis. Cholesterol esters and triglycerides mirrored the GPL changes, suggesting they were formed as GPL fatty acids were eliminated, probably by phagocytes. By contrast, the Cer initially produced remained high and unchanged in the tissue. Whether this is due to physical seclusion of Cer in a space inaccessible to phagocytes or to a Cd-related inhibition of ceramidase remains to be established
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/235762
Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium; XLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; Córdoba; Argentina; 2008; 92-92
0327-9545
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/235762
identifier_str_mv Rapid And Permanent Lipid Changes After Death Of Testicular Cells Induced By Exposure To Cadmium; XLIII Reunión Anual de la Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; Córdoba; Argentina; 2008; 92-92
0327-9545
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://newsite.saib.org.ar/publicaciones/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
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dc.publisher.none.fl_str_mv Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos
publisher.none.fl_str_mv Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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