Third molar agenesis as a potential marker for craniofacial deformities

Autores
Avelar Fernandez, Clarissa Christina; Vasconcellos Cruz Alves Pereira, Christiane; Raggio Luiz, Ronir; Faraco, Italo M.; Marazita, Mary L.; Arnaudo, Maria; de Carvalho, Flavia M.; Poletta, Fernando Adrián; Mereb, Juan C.; Castilla, Eduardo Enrique; Orioli, Ieda Maria; de Castro Costa, Marcelo; Rezende Vieira, Alexandre
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. Objective: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. Design: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. Results: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. Conclusion: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.
Fil: Avelar Fernandez, Clarissa Christina. Universidade Federal do Rio de Janeiro; Brasil
Fil: Vasconcellos Cruz Alves Pereira, Christiane. Universidade Federal do Rio de Janeiro; Brasil
Fil: Raggio Luiz, Ronir. Universidade Federal do Rio de Janeiro; Brasil
Fil: Faraco, Italo M.. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
Fil: Arnaudo, Maria. Centro de Educación Medica E Invest.clinicas; Argentina
Fil: de Carvalho, Flavia M.. Universidade Federal Do Rio de Janeiro. Instituto de Biología; Brasil
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Mereb, Juan C.. Centro de Educación Medica E Invest.clinicas; Argentina
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Orioli, Ieda Maria. Universidade Federal Do Rio de Janeiro. Instituto de Biología; Brasil
Fil: de Castro Costa, Marcelo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rezende Vieira, Alexandre. University of Pittsburgh at Johnstown; Estados Unidos
Materia
CLEFT LIP AND PALATE
CRANIOFACIAL DEFORMITIES
TOOTH AGENESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185353
Acceder
id CONICETDig_d47c06d218356b7bc9060a4677d33ba6
oai_identifier_str oai:ri.conicet.gov.ar:11336/185353
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Third molar agenesis as a potential marker for craniofacial deformitiesAvelar Fernandez, Clarissa ChristinaVasconcellos Cruz Alves Pereira, ChristianeRaggio Luiz, RonirFaraco, Italo M.Marazita, Mary L.Arnaudo, Mariade Carvalho, Flavia M.Poletta, Fernando AdriánMereb, Juan C.Castilla, Eduardo EnriqueOrioli, Ieda Mariade Castro Costa, MarceloRezende Vieira, AlexandreCLEFT LIP AND PALATECRANIOFACIAL DEFORMITIESTOOTH AGENESIShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. Objective: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. Design: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. Results: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. Conclusion: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.Fil: Avelar Fernandez, Clarissa Christina. Universidade Federal do Rio de Janeiro; BrasilFil: Vasconcellos Cruz Alves Pereira, Christiane. Universidade Federal do Rio de Janeiro; BrasilFil: Raggio Luiz, Ronir. Universidade Federal do Rio de Janeiro; BrasilFil: Faraco, Italo M.. University of Pittsburgh at Johnstown; Estados UnidosFil: Marazita, Mary L.. University of Pittsburgh; Estados UnidosFil: Arnaudo, Maria. Centro de Educación Medica E Invest.clinicas; ArgentinaFil: de Carvalho, Flavia M.. Universidade Federal Do Rio de Janeiro. Instituto de Biología; BrasilFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Mereb, Juan C.. Centro de Educación Medica E Invest.clinicas; ArgentinaFil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Orioli, Ieda Maria. Universidade Federal Do Rio de Janeiro. Instituto de Biología; BrasilFil: de Castro Costa, Marcelo. Universidade Federal do Rio de Janeiro; BrasilFil: Rezende Vieira, Alexandre. University of Pittsburgh at Johnstown; Estados UnidosPergamon-Elsevier Science Ltd2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185353Avelar Fernandez, Clarissa Christina; Vasconcellos Cruz Alves Pereira, Christiane; Raggio Luiz, Ronir; Faraco, Italo M.; Marazita, Mary L.; et al.; Third molar agenesis as a potential marker for craniofacial deformities; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 88; 4-2018; 19-230003-9969CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0003996918300104info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2018.01.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:41:18Zoai:ri.conicet.gov.ar:11336/185353instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:41:18.651CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Third molar agenesis as a potential marker for craniofacial deformities
title Third molar agenesis as a potential marker for craniofacial deformities
spellingShingle Third molar agenesis as a potential marker for craniofacial deformities
Avelar Fernandez, Clarissa Christina
CLEFT LIP AND PALATE
CRANIOFACIAL DEFORMITIES
TOOTH AGENESIS
title_short Third molar agenesis as a potential marker for craniofacial deformities
title_full Third molar agenesis as a potential marker for craniofacial deformities
title_fullStr Third molar agenesis as a potential marker for craniofacial deformities
title_full_unstemmed Third molar agenesis as a potential marker for craniofacial deformities
title_sort Third molar agenesis as a potential marker for craniofacial deformities
dc.creator.none.fl_str_mv Avelar Fernandez, Clarissa Christina
Vasconcellos Cruz Alves Pereira, Christiane
Raggio Luiz, Ronir
Faraco, Italo M.
Marazita, Mary L.
Arnaudo, Maria
de Carvalho, Flavia M.
Poletta, Fernando Adrián
Mereb, Juan C.
Castilla, Eduardo Enrique
Orioli, Ieda Maria
de Castro Costa, Marcelo
Rezende Vieira, Alexandre
author Avelar Fernandez, Clarissa Christina
author_facet Avelar Fernandez, Clarissa Christina
Vasconcellos Cruz Alves Pereira, Christiane
Raggio Luiz, Ronir
Faraco, Italo M.
Marazita, Mary L.
Arnaudo, Maria
de Carvalho, Flavia M.
Poletta, Fernando Adrián
Mereb, Juan C.
Castilla, Eduardo Enrique
Orioli, Ieda Maria
de Castro Costa, Marcelo
Rezende Vieira, Alexandre
author_role author
author2 Vasconcellos Cruz Alves Pereira, Christiane
Raggio Luiz, Ronir
Faraco, Italo M.
Marazita, Mary L.
Arnaudo, Maria
de Carvalho, Flavia M.
Poletta, Fernando Adrián
Mereb, Juan C.
Castilla, Eduardo Enrique
Orioli, Ieda Maria
de Castro Costa, Marcelo
Rezende Vieira, Alexandre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CLEFT LIP AND PALATE
CRANIOFACIAL DEFORMITIES
TOOTH AGENESIS
topic CLEFT LIP AND PALATE
CRANIOFACIAL DEFORMITIES
TOOTH AGENESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. Objective: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. Design: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. Results: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. Conclusion: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.
Fil: Avelar Fernandez, Clarissa Christina. Universidade Federal do Rio de Janeiro; Brasil
Fil: Vasconcellos Cruz Alves Pereira, Christiane. Universidade Federal do Rio de Janeiro; Brasil
Fil: Raggio Luiz, Ronir. Universidade Federal do Rio de Janeiro; Brasil
Fil: Faraco, Italo M.. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
Fil: Arnaudo, Maria. Centro de Educación Medica E Invest.clinicas; Argentina
Fil: de Carvalho, Flavia M.. Universidade Federal Do Rio de Janeiro. Instituto de Biología; Brasil
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Mereb, Juan C.. Centro de Educación Medica E Invest.clinicas; Argentina
Fil: Castilla, Eduardo Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Orioli, Ieda Maria. Universidade Federal Do Rio de Janeiro. Instituto de Biología; Brasil
Fil: de Castro Costa, Marcelo. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rezende Vieira, Alexandre. University of Pittsburgh at Johnstown; Estados Unidos
description The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. Objective: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. Design: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. Results: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. Conclusion: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185353
Avelar Fernandez, Clarissa Christina; Vasconcellos Cruz Alves Pereira, Christiane; Raggio Luiz, Ronir; Faraco, Italo M.; Marazita, Mary L.; et al.; Third molar agenesis as a potential marker for craniofacial deformities; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 88; 4-2018; 19-23
0003-9969
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185353
identifier_str_mv Avelar Fernandez, Clarissa Christina; Vasconcellos Cruz Alves Pereira, Christiane; Raggio Luiz, Ronir; Faraco, Italo M.; Marazita, Mary L.; et al.; Third molar agenesis as a potential marker for craniofacial deformities; Pergamon-Elsevier Science Ltd; Archives of Oral Biology; 88; 4-2018; 19-23
0003-9969
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0003996918300104
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.archoralbio.2018.01.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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