Tooth Agenesis Patterns in Orofacial Clefting Using Tooth Agenesis Code: A Meta-Analysis

• Autores: Howe, Brian J.; Pendleton, Chandler; Withanage, Miyuraj Harishchandra Hikkaduwa; Childs, Christopher A.; Zeng, Erliang; van Wijk, Arjen; Hermus, Ruurd; Padilla, Carmencita; Hecht, Jacqueline T.; Poletta, Fernando Adrián; Orioli, Ieda Maria; Buxó-Martínez, Carmen J.; Deleyiannis, Frederic; Vieira, Alexandre R.; Butali, Azeez; Valencian Ramirez, Consuelo; Muñeton, Claudia Restrepo; Wehby, George; Weinberg, Seth M.; Marazita, Mary L.; Moreno Uribe, Lina M.; Xie, Xian Jin
• Año de publicación: 2022
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: CLEFT LIP AND PALATE; HYPODONTIA; MACHINE LEARNING; PHENOTYPE
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Individuals with orofacial clefting (OFC) have a higher prevalence of tooth agenesis (TA) overall. Neither the precise etiology of TA, nor whether TA occurs in patterns that differ by gender or cleft type is yet known. This meta-analysis aims to identify the spectrum of tooth agenesis patterns in subjects with non-syndromic OFC and controls using the Tooth Agenesis Code (TAC) program. An indexed search of databases (PubMed, EMBASE, and CINAHL) along with cross-referencing and hand searches were completed from May to June 2019 and re-run in February 2022. Additionally, unpublished TAC data from 914 individuals with OFC and 932 controls were included. TAC pattern frequencies per study were analyzed using a random effects meta-analysis model. A thorough review of 45 records retrieved resulted in 4 articles meeting eligibility criteria, comprising 2182 subjects with OFC and 3171 controls. No TA (0.0.0.0) was seen in 51% of OFC cases and 97% of controls. TAC patterns 0.2.0.0, 2.0.0.0, and 2.2.0.0 indicating uni-or bi-lateral missing upper laterals, and 16.0.0.0 indicating missing upper right second premolar, were more common in subjects with OFC. Subjects with OFC have unique TA patterns and defining these patterns will help increase our understanding of the complex etiology underlying TA.
Fil: Howe, Brian J.. University of Iowa; Estados Unidos
Fil: Pendleton, Chandler. University of Iowa; Estados Unidos
Fil: Withanage, Miyuraj Harishchandra Hikkaduwa. University of Iowa; Estados Unidos
Fil: Childs, Christopher A.. University of Iowa; Estados Unidos
Fil: Zeng, Erliang. University of Iowa; Estados Unidos
Fil: van Wijk, Arjen. Academisch Centrum Tandheelkunde Amsterdam; Países Bajos
Fil: Hermus, Ruurd. Orthopraktijk Capelle; Países Bajos
Fil: Padilla, Carmencita. University Of The Philippines; Filipinas
Fil: Hecht, Jacqueline T.. University of Texas; Estados Unidos
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
Fil: Buxó-Martínez, Carmen J.. Universidad de Puerto Rico; Puerto Rico
Fil: Deleyiannis, Frederic. Uchealth Medical Group; Estados Unidos
Fil: Vieira, Alexandre R.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Butali, Azeez. University of Iowa; Estados Unidos
Fil: Valencian Ramirez, Consuelo. Clinica Noel; Colombia
Fil: Muñeton, Claudia Restrepo. Clinica Noel; Colombia
Fil: Wehby, George. University of Iowa; Estados Unidos
Fil: Weinberg, Seth M.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados Unidos
Fil: Moreno Uribe, Lina M.. University of Iowa; Estados Unidos
Fil: Xie, Xian Jin. University of Iowa; Estados Unidos