Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns

Autores
Neiswanger, Katherine; Mukhopadhyay, Nandita; Rajagopalan, Shwetha; Leslie, Elizabeth J.; Sanchez, Carla A.; Hecht, Jacqueline T.; Orioli, Ieda Maria; Poletta, Fernando Adrián; de Salamanca, Javier Enríquez; Weinberg, Seth M.; Marazita, Mary L.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.
Fil: Neiswanger, Katherine. University of Pittsburgh; Estados Unidos
Fil: Mukhopadhyay, Nandita. University of Pittsburgh; Estados Unidos
Fil: Rajagopalan, Shwetha. University of Pittsburgh; Estados Unidos
Fil: Leslie, Elizabeth J.. University of Pittsburgh; Estados Unidos
Fil: Sanchez, Carla A.. University of Pittsburgh; Estados Unidos
Fil: Hecht, Jacqueline T.. University Of Texas Health Science Center At Houston.; Estados Unidos
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: de Salamanca, Javier Enríquez. Hospital Infantil Universitario Niño Jesús; España
Fil: Weinberg, Seth M.. University of Pittsburgh; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
Materia
Oral cleft
Cleft lip
Cleft palate
Dermatogliphics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211479
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/211479
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patternsNeiswanger, KatherineMukhopadhyay, NanditaRajagopalan, ShwethaLeslie, Elizabeth J.Sanchez, Carla A.Hecht, Jacqueline T.Orioli, Ieda MariaPoletta, Fernando Adriánde Salamanca, Javier EnríquezWeinberg, Seth M.Marazita, Mary L.Oral cleftCleft lipCleft palateDermatogliphicshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.Fil: Neiswanger, Katherine. University of Pittsburgh; Estados UnidosFil: Mukhopadhyay, Nandita. University of Pittsburgh; Estados UnidosFil: Rajagopalan, Shwetha. University of Pittsburgh; Estados UnidosFil: Leslie, Elizabeth J.. University of Pittsburgh; Estados UnidosFil: Sanchez, Carla A.. University of Pittsburgh; Estados UnidosFil: Hecht, Jacqueline T.. University Of Texas Health Science Center At Houston.; Estados UnidosFil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; BrasilFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: de Salamanca, Javier Enríquez. Hospital Infantil Universitario Niño Jesús; EspañaFil: Weinberg, Seth M.. University of Pittsburgh; Estados UnidosFil: Marazita, Mary L.. University of Pittsburgh; Estados UnidosPublic Library of Science2020-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211479Neiswanger, Katherine; Mukhopadhyay, Nandita; Rajagopalan, Shwetha; Leslie, Elizabeth J.; Sanchez, Carla A.; et al.; Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns; Public Library of Science; Plos One; 15; 3; 3-2020; 1-161932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230534info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0230534info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:16Zoai:ri.conicet.gov.ar:11336/211479instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:16.709CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
title Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
spellingShingle Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
Neiswanger, Katherine
Oral cleft
Cleft lip
Cleft palate
Dermatogliphics
title_short Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
title_full Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
title_fullStr Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
title_full_unstemmed Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
title_sort Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns
dc.creator.none.fl_str_mv Neiswanger, Katherine
Mukhopadhyay, Nandita
Rajagopalan, Shwetha
Leslie, Elizabeth J.
Sanchez, Carla A.
Hecht, Jacqueline T.
Orioli, Ieda Maria
Poletta, Fernando Adrián
de Salamanca, Javier Enríquez
Weinberg, Seth M.
Marazita, Mary L.
author Neiswanger, Katherine
author_facet Neiswanger, Katherine
Mukhopadhyay, Nandita
Rajagopalan, Shwetha
Leslie, Elizabeth J.
Sanchez, Carla A.
Hecht, Jacqueline T.
Orioli, Ieda Maria
Poletta, Fernando Adrián
de Salamanca, Javier Enríquez
Weinberg, Seth M.
Marazita, Mary L.
author_role author
author2 Mukhopadhyay, Nandita
Rajagopalan, Shwetha
Leslie, Elizabeth J.
Sanchez, Carla A.
Hecht, Jacqueline T.
Orioli, Ieda Maria
Poletta, Fernando Adrián
de Salamanca, Javier Enríquez
Weinberg, Seth M.
Marazita, Mary L.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oral cleft
Cleft lip
Cleft palate
Dermatogliphics
topic Oral cleft
Cleft lip
Cleft palate
Dermatogliphics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.
Fil: Neiswanger, Katherine. University of Pittsburgh; Estados Unidos
Fil: Mukhopadhyay, Nandita. University of Pittsburgh; Estados Unidos
Fil: Rajagopalan, Shwetha. University of Pittsburgh; Estados Unidos
Fil: Leslie, Elizabeth J.. University of Pittsburgh; Estados Unidos
Fil: Sanchez, Carla A.. University of Pittsburgh; Estados Unidos
Fil: Hecht, Jacqueline T.. University Of Texas Health Science Center At Houston.; Estados Unidos
Fil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; Brasil
Fil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: de Salamanca, Javier Enríquez. Hospital Infantil Universitario Niño Jesús; España
Fil: Weinberg, Seth M.. University of Pittsburgh; Estados Unidos
Fil: Marazita, Mary L.. University of Pittsburgh; Estados Unidos
description Dermatoglyphic patterns on the fingers often differ in syndromes and other conditions with a developmental component, compared to the general population. Previous literature on the relationship between orofacial clefts-the most common craniofacial birth defect in humans-and dermatoglyphics is inconsistent, with some studies reporting altered pattern frequencies and/or increased asymmetry and others failing to find differences. To investigate dermatoglyphics in orofacial clefting, we obtained dermatoglyphic patterns in a large multiethnic cohort of orofacial cleft cases (N = 367), their unaffected family members (N = 836), and controls (N = 299). We categorized fingerprint pattern types from males and females who participated at five sites of the Pittsburgh Orofacial Cleft study (Hungary, United States of America (Pennsylvania, Texas), Spain, and Argentina). We also calculated a pattern dissimilarity score for each individual as a measure of left-right asymmetry. We tested for group differences in the number of arches, ulnar and radial loops, and whorls on each individual's hands, and in the pattern dissimilarity scores using ANOVA. After taking sex and site differences into account, we did not find any significant pattern count differences between cleft and non-cleft individuals. Notably, we did observe increased pattern dissimilarity in individuals with clefts, compared to both their unaffected relatives and controls. Increased dermatoglyphic pattern dissimilarity in individuals with nonsyndromic orofacial clefts may reflect a generalized developmental instability.
publishDate 2020
dc.date.none.fl_str_mv 2020-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211479
Neiswanger, Katherine; Mukhopadhyay, Nandita; Rajagopalan, Shwetha; Leslie, Elizabeth J.; Sanchez, Carla A.; et al.; Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns; Public Library of Science; Plos One; 15; 3; 3-2020; 1-16
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211479
identifier_str_mv Neiswanger, Katherine; Mukhopadhyay, Nandita; Rajagopalan, Shwetha; Leslie, Elizabeth J.; Sanchez, Carla A.; et al.; Individuals with nonsyndromic orofacial clefts have increased asymmetry of fingerprint patterns; Public Library of Science; Plos One; 15; 3; 3-2020; 1-16
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230534
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0230534
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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