Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome

Autores
Motta, Alicia Beatriz
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
Polycystic Ovary Syndrome
Metformin
Pregnancy
Clomiphene Citrate
Diabetes
Adolescents
Ovulation
Cardiovascular
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20288
Acceder
id CONICETDig_d45f0736b704b4811080f62adaba13fb
oai_identifier_str oai:ri.conicet.gov.ar:11336/20288
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mechanisms involved in metformin action in the treatment of Polycystic Ovary SyndromeMotta, Alicia BeatrizPolycystic Ovary SyndromeMetforminPregnancyClomiphene CitrateDiabetesAdolescentsOvulationCardiovascularhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaBentham Science Publishers2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20288Motta, Alicia Beatriz; Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design; 15; 26; 12-2009; 3074-30771381-61281873-4286CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/138161209789058101info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/69945/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:21Zoai:ri.conicet.gov.ar:11336/20288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:21.438CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
title Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
spellingShingle Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
Motta, Alicia Beatriz
Polycystic Ovary Syndrome
Metformin
Pregnancy
Clomiphene Citrate
Diabetes
Adolescents
Ovulation
Cardiovascular
title_short Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
title_full Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
title_fullStr Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
title_full_unstemmed Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
title_sort Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome
dc.creator.none.fl_str_mv Motta, Alicia Beatriz
author Motta, Alicia Beatriz
author_facet Motta, Alicia Beatriz
author_role author
dc.subject.none.fl_str_mv Polycystic Ovary Syndrome
Metformin
Pregnancy
Clomiphene Citrate
Diabetes
Adolescents
Ovulation
Cardiovascular
topic Polycystic Ovary Syndrome
Metformin
Pregnancy
Clomiphene Citrate
Diabetes
Adolescents
Ovulation
Cardiovascular
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description The N, N dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulinsensitive tissues. As Polycystic Ovary Syndrome (PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome- the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
publishDate 2009
dc.date.none.fl_str_mv 2009-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20288
Motta, Alicia Beatriz; Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design; 15; 26; 12-2009; 3074-3077
1381-6128
1873-4286
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20288
identifier_str_mv Motta, Alicia Beatriz; Mechanisms involved in metformin action in the treatment of Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design; 15; 26; 12-2009; 3074-3077
1381-6128
1873-4286
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/138161209789058101
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/69945/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270041215598592
score 13.13397

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