Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome

Autores
Motta, Alicia Beatriz
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model showing the salient features found in women with PCOS was developed by the injection of DHEA. Although insulin-sensitizing agents, such as biguanides, are clinically used in the treatment of diabetes and PCOS, the complete understanding of their mechanisms of action remains unknown. The present review discusses the molecular mechanisms involved in the development of PCOS by using the DHEA-PCOS murine model and analyzes the role of the biguanide metformin as treatment.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
Dehydroepiandrosterone
Murine Models
Polycystic Ovary Syndrome
Metformin
Pregnancy
Ovulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/17246
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/17246
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary SyndromeMotta, Alicia BeatrizDehydroepiandrosteroneMurine ModelsPolycystic Ovary SyndromeMetforminPregnancyOvulationhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model showing the salient features found in women with PCOS was developed by the injection of DHEA. Although insulin-sensitizing agents, such as biguanides, are clinically used in the treatment of diabetes and PCOS, the complete understanding of their mechanisms of action remains unknown. The present review discusses the molecular mechanisms involved in the development of PCOS by using the DHEA-PCOS murine model and analyzes the role of the biguanide metformin as treatment.Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaElsevier2010-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/17246Motta, Alicia Beatriz; Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 119; 3-5; 4-2010; 105-1110960-0760enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2010.02.015info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076010000695info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:25Zoai:ri.conicet.gov.ar:11336/17246instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:25.819CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
title Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
spellingShingle Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
Motta, Alicia Beatriz
Dehydroepiandrosterone
Murine Models
Polycystic Ovary Syndrome
Metformin
Pregnancy
Ovulation
title_short Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
title_full Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
title_fullStr Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
title_full_unstemmed Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
title_sort Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome
dc.creator.none.fl_str_mv Motta, Alicia Beatriz
author Motta, Alicia Beatriz
author_facet Motta, Alicia Beatriz
author_role author
dc.subject.none.fl_str_mv Dehydroepiandrosterone
Murine Models
Polycystic Ovary Syndrome
Metformin
Pregnancy
Ovulation
topic Dehydroepiandrosterone
Murine Models
Polycystic Ovary Syndrome
Metformin
Pregnancy
Ovulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model showing the salient features found in women with PCOS was developed by the injection of DHEA. Although insulin-sensitizing agents, such as biguanides, are clinically used in the treatment of diabetes and PCOS, the complete understanding of their mechanisms of action remains unknown. The present review discusses the molecular mechanisms involved in the development of PCOS by using the DHEA-PCOS murine model and analyzes the role of the biguanide metformin as treatment.
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description During the last decade a battery of animal models used for the study of polycystic ovary syndrome (PCOS) have allowed a focus on different aspects of the pathology. Since dehydroepiandrosterone (DHEA) was found to be one of the most abundant circulating androgens in women with PCOS, a rodent model showing the salient features found in women with PCOS was developed by the injection of DHEA. Although insulin-sensitizing agents, such as biguanides, are clinically used in the treatment of diabetes and PCOS, the complete understanding of their mechanisms of action remains unknown. The present review discusses the molecular mechanisms involved in the development of PCOS by using the DHEA-PCOS murine model and analyzes the role of the biguanide metformin as treatment.
publishDate 2010
dc.date.none.fl_str_mv 2010-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/17246
Motta, Alicia Beatriz; Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 119; 3-5; 4-2010; 105-111
0960-0760
url http://hdl.handle.net/11336/17246
identifier_str_mv Motta, Alicia Beatriz; Dehydroepiandrosterone to induce murine models for the study of Polycystic Ovary Syndrome; Elsevier; Journal of Steroid Biochemistry and Molecular Biology; 119; 3-5; 4-2010; 105-111
0960-0760
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsbmb.2010.02.015
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0960076010000695
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269637003182080
score 13.13397

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