Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo

Autores
Bueno Junior, Lezio; Ruggiero, Rafael N.; Rossignoli, Matheus T.; Del Bel, Elaine A.; Leite, Joao; Uchitel, Osvaldo Daniel
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide – a carbonic anhydrase inhibitor – has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.
Fil: Bueno Junior, Lezio. Universidade de Sao Paulo; Brasil
Fil: Ruggiero, Rafael N.. Universidade de Sao Paulo; Brasil
Fil: Rossignoli, Matheus T.. Universidade de Sao Paulo; Brasil
Fil: Del Bel, Elaine A.. Universidade de Sao Paulo; Brasil
Fil: Leite, Joao. Universidade de Sao Paulo; Brasil
Fil: Uchitel, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Materia
CARBONIC ANHYDRASE
HIPPOCAMPUS
PREFRONTAL CORTEX
SINGLE-UNIT ACTIVITY
SYNAPTIC PLASTICITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67700
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Acetazolamide potentiates the afferent drive to prefrontal cortex in vivoBueno Junior, LezioRuggiero, Rafael N.Rossignoli, Matheus T.Del Bel, Elaine A.Leite, JoaoUchitel, Osvaldo DanielCARBONIC ANHYDRASEHIPPOCAMPUSPREFRONTAL CORTEXSINGLE-UNIT ACTIVITYSYNAPTIC PLASTICITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide – a carbonic anhydrase inhibitor – has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.Fil: Bueno Junior, Lezio. Universidade de Sao Paulo; BrasilFil: Ruggiero, Rafael N.. Universidade de Sao Paulo; BrasilFil: Rossignoli, Matheus T.. Universidade de Sao Paulo; BrasilFil: Del Bel, Elaine A.. Universidade de Sao Paulo; BrasilFil: Leite, Joao. Universidade de Sao Paulo; BrasilFil: Uchitel, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaAmerican Physiological Society2017-01-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67700Bueno Junior, Lezio; Ruggiero, Rafael N.; Rossignoli, Matheus T.; Del Bel, Elaine A.; Leite, Joao; et al.; Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo; American Physiological Society; Physiological Reports; 5; 1; 5-1-2017; 1-72051-817XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13066info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13066info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:57:38Zoai:ri.conicet.gov.ar:11336/67700instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:57:38.893CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
title Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
spellingShingle Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
Bueno Junior, Lezio
CARBONIC ANHYDRASE
HIPPOCAMPUS
PREFRONTAL CORTEX
SINGLE-UNIT ACTIVITY
SYNAPTIC PLASTICITY
title_short Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
title_full Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
title_fullStr Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
title_full_unstemmed Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
title_sort Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo
dc.creator.none.fl_str_mv Bueno Junior, Lezio
Ruggiero, Rafael N.
Rossignoli, Matheus T.
Del Bel, Elaine A.
Leite, Joao
Uchitel, Osvaldo Daniel
author Bueno Junior, Lezio
author_facet Bueno Junior, Lezio
Ruggiero, Rafael N.
Rossignoli, Matheus T.
Del Bel, Elaine A.
Leite, Joao
Uchitel, Osvaldo Daniel
author_role author
author2 Ruggiero, Rafael N.
Rossignoli, Matheus T.
Del Bel, Elaine A.
Leite, Joao
Uchitel, Osvaldo Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CARBONIC ANHYDRASE
HIPPOCAMPUS
PREFRONTAL CORTEX
SINGLE-UNIT ACTIVITY
SYNAPTIC PLASTICITY
topic CARBONIC ANHYDRASE
HIPPOCAMPUS
PREFRONTAL CORTEX
SINGLE-UNIT ACTIVITY
SYNAPTIC PLASTICITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide – a carbonic anhydrase inhibitor – has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.
Fil: Bueno Junior, Lezio. Universidade de Sao Paulo; Brasil
Fil: Ruggiero, Rafael N.. Universidade de Sao Paulo; Brasil
Fil: Rossignoli, Matheus T.. Universidade de Sao Paulo; Brasil
Fil: Del Bel, Elaine A.. Universidade de Sao Paulo; Brasil
Fil: Leite, Joao. Universidade de Sao Paulo; Brasil
Fil: Uchitel, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
description The knowledge on real-time neurophysiological effects of acetazolamide is still far behind the wide clinical use of this drug. Acetazolamide – a carbonic anhydrase inhibitor – has been shown to affect the neuromuscular transmission, implying a pH-mediated influence on the central synaptic transmission. To start filling such a gap, we chose a central substrate: hippocampal-prefrontal cortical projections; and a synaptic phenomenon: paired-pulse facilitation (a form of synaptic plasticity) to probe this drug's effects on interareal brain communication in chronically implanted rats. We observed that systemic acetazolamide potentiates the hippocampal-prefrontal paired-pulse facilitation. In addition to this field electrophysiology data, we found that acetazolamide exerts a net inhibitory effect on prefrontal cortical single-unit firing. We propose that systemic acetazolamide reduces the basal neuronal activity of the prefrontal cortex, whereas increasing the afferent drive it receives from the hippocampus. In addition to being relevant to the clinical and side effects of acetazolamide, these results suggest that exogenous pH regulation can have diverse impacts on afferent signaling across the neocortex.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67700
Bueno Junior, Lezio; Ruggiero, Rafael N.; Rossignoli, Matheus T.; Del Bel, Elaine A.; Leite, Joao; et al.; Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo; American Physiological Society; Physiological Reports; 5; 1; 5-1-2017; 1-7
2051-817X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67700
identifier_str_mv Bueno Junior, Lezio; Ruggiero, Rafael N.; Rossignoli, Matheus T.; Del Bel, Elaine A.; Leite, Joao; et al.; Acetazolamide potentiates the afferent drive to prefrontal cortex in vivo; American Physiological Society; Physiological Reports; 5; 1; 5-1-2017; 1-7
2051-817X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13066
info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13066
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1843606247900708864
score 13.001348

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