Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
- Autores
- Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina - Materia
-
CATALASE ACTIVITY
SCHIFF BASE LIGANDS
SOD MODELS
WATER SOLUBLE MN COMPLEXES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/131329
Ver los metadatos del registro completo
id |
CONICETDig_d23097fb2c6e628f5675df5532677dbb |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/131329 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligandsMoreno, Diego MartinDaier, Veronica AndreaPalopoli, Claudia MarcelaTuchagues, Jean PierreSignorella, Sandra RosannaCATALASE ACTIVITYSCHIFF BASE LIGANDSSOD MODELSWATER SOLUBLE MN COMPLEXEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; FranciaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaElsevier Science Inc2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131329Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-5020162-0134CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2009.12.016info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013409003213info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:42Zoai:ri.conicet.gov.ar:11336/131329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:42.538CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
title |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
spellingShingle |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands Moreno, Diego Martin CATALASE ACTIVITY SCHIFF BASE LIGANDS SOD MODELS WATER SOLUBLE MN COMPLEXES |
title_short |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
title_full |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
title_fullStr |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
title_full_unstemmed |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
title_sort |
Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands |
dc.creator.none.fl_str_mv |
Moreno, Diego Martin Daier, Veronica Andrea Palopoli, Claudia Marcela Tuchagues, Jean Pierre Signorella, Sandra Rosanna |
author |
Moreno, Diego Martin |
author_facet |
Moreno, Diego Martin Daier, Veronica Andrea Palopoli, Claudia Marcela Tuchagues, Jean Pierre Signorella, Sandra Rosanna |
author_role |
author |
author2 |
Daier, Veronica Andrea Palopoli, Claudia Marcela Tuchagues, Jean Pierre Signorella, Sandra Rosanna |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
CATALASE ACTIVITY SCHIFF BASE LIGANDS SOD MODELS WATER SOLUBLE MN COMPLEXES |
topic |
CATALASE ACTIVITY SCHIFF BASE LIGANDS SOD MODELS WATER SOLUBLE MN COMPLEXES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants. Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina |
description |
Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/131329 Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-502 0162-0134 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/131329 |
identifier_str_mv |
Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-502 0162-0134 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2009.12.016 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013409003213 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc |
publisher.none.fl_str_mv |
Elsevier Science Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844613855975571456 |
score |
13.070432 |