Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands

Autores
Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
CATALASE ACTIVITY
SCHIFF BASE LIGANDS
SOD MODELS
WATER SOLUBLE MN COMPLEXES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/131329
Acceder
id CONICETDig_d23097fb2c6e628f5675df5532677dbb
oai_identifier_str oai:ri.conicet.gov.ar:11336/131329
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligandsMoreno, Diego MartinDaier, Veronica AndreaPalopoli, Claudia MarcelaTuchagues, Jean PierreSignorella, Sandra RosannaCATALASE ACTIVITYSCHIFF BASE LIGANDSSOD MODELSWATER SOLUBLE MN COMPLEXEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; FranciaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaElsevier Science Inc2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131329Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-5020162-0134CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2009.12.016info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013409003213info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:00:20Zoai:ri.conicet.gov.ar:11336/131329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:00:20.817CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
title Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
spellingShingle Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
Moreno, Diego Martin
CATALASE ACTIVITY
SCHIFF BASE LIGANDS
SOD MODELS
WATER SOLUBLE MN COMPLEXES
title_short Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
title_full Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
title_fullStr Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
title_full_unstemmed Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
title_sort Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands
dc.creator.none.fl_str_mv Moreno, Diego Martin
Daier, Veronica Andrea
Palopoli, Claudia Marcela
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author Moreno, Diego Martin
author_facet Moreno, Diego Martin
Daier, Veronica Andrea
Palopoli, Claudia Marcela
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author_role author
author2 Daier, Veronica Andrea
Palopoli, Claudia Marcela
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author2_role author
author
author
author
dc.subject.none.fl_str_mv CATALASE ACTIVITY
SCHIFF BASE LIGANDS
SOD MODELS
WATER SOLUBLE MN COMPLEXES
topic CATALASE ACTIVITY
SCHIFF BASE LIGANDS
SOD MODELS
WATER SOLUBLE MN COMPLEXES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Palopoli, Claudia Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Tuchagues, Jean Pierre. Université de Toulouse; Francia. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description Two new MnIII complexes Na[Mn(5-SO3-salpnOH)(H2O)]{dot operator}5H2O (1) and Na[Mn(5-SO3-salpn)(MeOH)]{dot operator}4H2O (2) (5-SO3-salpnOH=1,3-bis(5-sulphonatosalicylidenamino)propan-2-ol, 5-SO3-salpn=1,3-bis(5-sulphonatosalicylidenamino)propane) have been prepared and characterized. Electrospray ionization-mass spectrometry, UV-visible and 1H NMR spectroscopic studies showed that the two complexes exist in solution as monoanions [Mn(5-SO3-salpn(OH))(solvent)2]-, with the ligand bound to MnIII through the two phenolato-O and two imino-N atoms located in the equatorial plane. The E1/2 of the MnIII/MnII couple (-47.11 (1) and -77.80mV (2) vs. Ag/AgCl) allows these complexes to efficiently catalyze the dismutation of O2-, with catalytic rate constants 2.4×106 (1) and 3.6×106 (2) M-1s-1, and IC50 values of 1.14 (1) and 0.77 (2) μM, obtained through the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. The two complexes are also able to disproportionate up to 250 equivalents of H2O2 in aqueous solution of pH 8.0, with initial turnover rates of 178 (1) and 25.2 (2) mM H2O2 min-1mM-1catalyst-1. Their dual superoxide dismutase/catalase activity renders these compounds particularly attractive as catalytic antioxidants.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/131329
Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-502
0162-0134
CONICET Digital
CONICET
url http://hdl.handle.net/11336/131329
identifier_str_mv Moreno, Diego Martin; Daier, Veronica Andrea; Palopoli, Claudia Marcela; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, characterization and antioxidant activity of water soluble MnIII complexes of sulphonato-substituted Schiff base ligands; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 5; 5-2010; 496-502
0162-0134
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2009.12.016
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013409003213
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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