Multilobular morphology: the key for biphase multitask nanogels

Autores
Sonzogni, Ana Sofía; Hamzehlou, Shaghayegh; González, Verónica Doris Guadalupe; Leiza, Jose Ramon; Minari, Roque Javier
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Nanogels play a leading role in controlled release systems because they possess high water retention capacity resulting in high loading capabilities, stability in biological fluids and biocompatibility. In this scenario, every tool that allows extending the nanogel properties and expanding their potential applications is of high interest in the field of biomedicine. This article aims to contribute to the development of multifunctional nanogels, based on the combination of two polymer phases in a multilobular morphology. The synthesized multilobed nanogels (mLNGs) presented a core of crosslinked poly(N-vinylcaprolactam) (PVCL) and a shell formed by 3-D distributed lobes of a lowTgcopolymer. This particular multilobular morphology is able to exploit the synergetic contribution of both phases. While the PVCL-based core conferred its characteristic thermal response and the ability to load and release a cargo molecule, the lowTglobes incorporated the capability of film formation. Moreover, the multilobular arrangement of NGs allows films to undergo unrestricted mass transfer. The development of mLNG morphology and the effect of synthesis parameters were deeply studied with the help of a previously developed mathematical model for the dynamic evolution of particle morphology. Finally, this study presents, for the first time, the synthesis of two-phase nanogels with multilobular morphology and underlines their potential as a candidate for controlled delivery platforms.
Fil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Hamzehlou, Shaghayegh. Universidad del País Vasco; España
Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Leiza, Jose Ramon. Universidad del País Vasco; España
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
NANOGELS
FILM FORMING
MULTIFUNCTIONAL NANO-PLATFORM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/150217
Acceder
id CONICETDig_d1d47408aea434ff1b1a1ec96a11e29c
oai_identifier_str oai:ri.conicet.gov.ar:11336/150217
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multilobular morphology: the key for biphase multitask nanogelsSonzogni, Ana SofíaHamzehlou, ShaghayeghGonzález, Verónica Doris GuadalupeLeiza, Jose RamonMinari, Roque JavierNANOGELSFILM FORMINGMULTIFUNCTIONAL NANO-PLATFORMhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Nanogels play a leading role in controlled release systems because they possess high water retention capacity resulting in high loading capabilities, stability in biological fluids and biocompatibility. In this scenario, every tool that allows extending the nanogel properties and expanding their potential applications is of high interest in the field of biomedicine. This article aims to contribute to the development of multifunctional nanogels, based on the combination of two polymer phases in a multilobular morphology. The synthesized multilobed nanogels (mLNGs) presented a core of crosslinked poly(N-vinylcaprolactam) (PVCL) and a shell formed by 3-D distributed lobes of a lowTgcopolymer. This particular multilobular morphology is able to exploit the synergetic contribution of both phases. While the PVCL-based core conferred its characteristic thermal response and the ability to load and release a cargo molecule, the lowTglobes incorporated the capability of film formation. Moreover, the multilobular arrangement of NGs allows films to undergo unrestricted mass transfer. The development of mLNG morphology and the effect of synthesis parameters were deeply studied with the help of a previously developed mathematical model for the dynamic evolution of particle morphology. Finally, this study presents, for the first time, the synthesis of two-phase nanogels with multilobular morphology and underlines their potential as a candidate for controlled delivery platforms.Fil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Hamzehlou, Shaghayegh. Universidad del País Vasco; EspañaFil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Leiza, Jose Ramon. Universidad del País Vasco; EspañaFil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaRoyal Society of Chemistry2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/150217Sonzogni, Ana Sofía; Hamzehlou, Shaghayegh; González, Verónica Doris Guadalupe; Leiza, Jose Ramon; Minari, Roque Javier; Multilobular morphology: the key for biphase multitask nanogels; Royal Society of Chemistry; Soft Matter; 17; 41; 9-2021; 9353-93621744-683XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2021/SM/D1SM00968Kinfo:eu-repo/semantics/altIdentifier/doi/10.1039/D1SM00968Kinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:13:59Zoai:ri.conicet.gov.ar:11336/150217instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:13:59.486CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multilobular morphology: the key for biphase multitask nanogels
title Multilobular morphology: the key for biphase multitask nanogels
spellingShingle Multilobular morphology: the key for biphase multitask nanogels
Sonzogni, Ana Sofía
NANOGELS
FILM FORMING
MULTIFUNCTIONAL NANO-PLATFORM
title_short Multilobular morphology: the key for biphase multitask nanogels
title_full Multilobular morphology: the key for biphase multitask nanogels
title_fullStr Multilobular morphology: the key for biphase multitask nanogels
title_full_unstemmed Multilobular morphology: the key for biphase multitask nanogels
title_sort Multilobular morphology: the key for biphase multitask nanogels
dc.creator.none.fl_str_mv Sonzogni, Ana Sofía
Hamzehlou, Shaghayegh
González, Verónica Doris Guadalupe
Leiza, Jose Ramon
Minari, Roque Javier
author Sonzogni, Ana Sofía
author_facet Sonzogni, Ana Sofía
Hamzehlou, Shaghayegh
González, Verónica Doris Guadalupe
Leiza, Jose Ramon
Minari, Roque Javier
author_role author
author2 Hamzehlou, Shaghayegh
González, Verónica Doris Guadalupe
Leiza, Jose Ramon
Minari, Roque Javier
author2_role author
author
author
author
dc.subject.none.fl_str_mv NANOGELS
FILM FORMING
MULTIFUNCTIONAL NANO-PLATFORM
topic NANOGELS
FILM FORMING
MULTIFUNCTIONAL NANO-PLATFORM
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Nanogels play a leading role in controlled release systems because they possess high water retention capacity resulting in high loading capabilities, stability in biological fluids and biocompatibility. In this scenario, every tool that allows extending the nanogel properties and expanding their potential applications is of high interest in the field of biomedicine. This article aims to contribute to the development of multifunctional nanogels, based on the combination of two polymer phases in a multilobular morphology. The synthesized multilobed nanogels (mLNGs) presented a core of crosslinked poly(N-vinylcaprolactam) (PVCL) and a shell formed by 3-D distributed lobes of a lowTgcopolymer. This particular multilobular morphology is able to exploit the synergetic contribution of both phases. While the PVCL-based core conferred its characteristic thermal response and the ability to load and release a cargo molecule, the lowTglobes incorporated the capability of film formation. Moreover, the multilobular arrangement of NGs allows films to undergo unrestricted mass transfer. The development of mLNG morphology and the effect of synthesis parameters were deeply studied with the help of a previously developed mathematical model for the dynamic evolution of particle morphology. Finally, this study presents, for the first time, the synthesis of two-phase nanogels with multilobular morphology and underlines their potential as a candidate for controlled delivery platforms.
Fil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Hamzehlou, Shaghayegh. Universidad del País Vasco; España
Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Leiza, Jose Ramon. Universidad del País Vasco; España
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Nanogels play a leading role in controlled release systems because they possess high water retention capacity resulting in high loading capabilities, stability in biological fluids and biocompatibility. In this scenario, every tool that allows extending the nanogel properties and expanding their potential applications is of high interest in the field of biomedicine. This article aims to contribute to the development of multifunctional nanogels, based on the combination of two polymer phases in a multilobular morphology. The synthesized multilobed nanogels (mLNGs) presented a core of crosslinked poly(N-vinylcaprolactam) (PVCL) and a shell formed by 3-D distributed lobes of a lowTgcopolymer. This particular multilobular morphology is able to exploit the synergetic contribution of both phases. While the PVCL-based core conferred its characteristic thermal response and the ability to load and release a cargo molecule, the lowTglobes incorporated the capability of film formation. Moreover, the multilobular arrangement of NGs allows films to undergo unrestricted mass transfer. The development of mLNG morphology and the effect of synthesis parameters were deeply studied with the help of a previously developed mathematical model for the dynamic evolution of particle morphology. Finally, this study presents, for the first time, the synthesis of two-phase nanogels with multilobular morphology and underlines their potential as a candidate for controlled delivery platforms.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/150217
Sonzogni, Ana Sofía; Hamzehlou, Shaghayegh; González, Verónica Doris Guadalupe; Leiza, Jose Ramon; Minari, Roque Javier; Multilobular morphology: the key for biphase multitask nanogels; Royal Society of Chemistry; Soft Matter; 17; 41; 9-2021; 9353-9362
1744-683X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/150217
identifier_str_mv Sonzogni, Ana Sofía; Hamzehlou, Shaghayegh; González, Verónica Doris Guadalupe; Leiza, Jose Ramon; Minari, Roque Javier; Multilobular morphology: the key for biphase multitask nanogels; Royal Society of Chemistry; Soft Matter; 17; 41; 9-2021; 9353-9362
1744-683X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2021/SM/D1SM00968K
info:eu-repo/semantics/altIdentifier/doi/10.1039/D1SM00968K
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980743795441664
score 12.993085

Publicaciones similares