LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release

Autores
Cussa, Jorgelina; Juarez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Juarez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Materia
DRUG-DELIVERING DEVICE
KETOROLAC TROMETHAMINE
LP-SBA-15
NANOSCALE MEDICINE
NANOSTRUCTURED HOST
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/188234
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto ReleaseCussa, JorgelinaJuarez, JulianaGómez Costa, Marcos BrunoAnunziata, Oscar AlfredoDRUG-DELIVERING DEVICEKETOROLAC TROMETHAMINELP-SBA-15NANOSCALE MEDICINENANOSTRUCTURED HOSThttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;Fil: Juarez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;AMG Transcend Association2022-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/188234Cussa, Jorgelina; Juarez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo; LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release; AMG Transcend Association; Biointerface Research in Applied Chemistry; 13; 3; 6-2022; 1-142069-5837CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://biointerfaceresearch.com/wp-content/uploads/2022/06/BRIAC133.243.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.33263/BRIAC133.243info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:19:26Zoai:ri.conicet.gov.ar:11336/188234instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:19:27.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
title LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
spellingShingle LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
Cussa, Jorgelina
DRUG-DELIVERING DEVICE
KETOROLAC TROMETHAMINE
LP-SBA-15
NANOSCALE MEDICINE
NANOSTRUCTURED HOST
title_short LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
title_full LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
title_fullStr LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
title_full_unstemmed LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
title_sort LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release
dc.creator.none.fl_str_mv Cussa, Jorgelina
Juarez, Juliana
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author Cussa, Jorgelina
author_facet Cussa, Jorgelina
Juarez, Juliana
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author_role author
author2 Juarez, Juliana
Gómez Costa, Marcos Bruno
Anunziata, Oscar Alfredo
author2_role author
author
author
dc.subject.none.fl_str_mv DRUG-DELIVERING DEVICE
KETOROLAC TROMETHAMINE
LP-SBA-15
NANOSCALE MEDICINE
NANOSTRUCTURED HOST
topic DRUG-DELIVERING DEVICE
KETOROLAC TROMETHAMINE
LP-SBA-15
NANOSCALE MEDICINE
NANOSTRUCTURED HOST
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
Fil: Cussa, Jorgelina. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Juarez, Juliana. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Gómez Costa, Marcos Bruno. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
Fil: Anunziata, Oscar Alfredo. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación en Nanociencia y Nanotecnología; Argentina. Centro de Investigaciones Cientificas ; Facultad de Ciencias Exactas Fisicas y Naturales ; Universidad Nacional de Cordoba;
description Drug-controlled release systems can keep the level of drugs in precise doses in the body above the optimal level and with low toxicity. We propose the nanomaterial LP-SBA-15 as an attractive new host for drug delivery systems due to its high biocompatibility, in vivo biodegradability, and low toxicity. LP-SBA-15/Ketorolac was prepared and characterized by XRD, FTIR, UV-Vis DRS, TEM, and texture analysis, determining the adsorption capacity and its release and achieving the required therapeutic efficacy. The host shows the ordered mesoporous nanochannels with a diameter of 11-12 nm, maintaining the structure with the incorporation of Keto. The mechanism of drug release from the LP-SBA-15 host was evaluated. Different mathematical models were used to adjust the experimental data, the Ritger-Peppas model followed by the Weibull model the best ones. The promising results we obtained for the release of the drug thoroughly using the new material, reaching a rapid initial release rate, and maintaining a constant rate afterward, allow us to maintain the concentration of the drug in the therapeutic efficacy range, applying it largely to the treatment of diseases that require a rapid response.
publishDate 2022
dc.date.none.fl_str_mv 2022-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/188234
Cussa, Jorgelina; Juarez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo; LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release; AMG Transcend Association; Biointerface Research in Applied Chemistry; 13; 3; 6-2022; 1-14
2069-5837
CONICET Digital
CONICET
url http://hdl.handle.net/11336/188234
identifier_str_mv Cussa, Jorgelina; Juarez, Juliana; Gómez Costa, Marcos Bruno; Anunziata, Oscar Alfredo; LP-SBA-15/Ketorolac Nanocomposite: Development, Characterization, and Mathematical Modeling of Controlled Keto Release; AMG Transcend Association; Biointerface Research in Applied Chemistry; 13; 3; 6-2022; 1-14
2069-5837
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://biointerfaceresearch.com/wp-content/uploads/2022/06/BRIAC133.243.pdf
info:eu-repo/semantics/altIdentifier/doi/10.33263/BRIAC133.243
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AMG Transcend Association
publisher.none.fl_str_mv AMG Transcend Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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