Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala

Autores
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; Corbin, Joshua G.
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
Fil: Li, Peijun. University Of Georgetown; Estados Unidos
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados Unidos
Fil: Huntsman, Molly M.. University Of Georgetown; Estados Unidos
Fil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
Materia
Amigdala
Development
Transcription Factor
Thelencephalon
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20755
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdalaHirata, TsutomuLi, PeijunLanuza, Guillermo MarcosCocas, Laura A.Huntsman, Molly M.Corbin, Joshua G.AmigdalaDevelopmentTranscription FactorThelencephalonhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados UnidosFil: Li, Peijun. University Of Georgetown; Estados UnidosFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados UnidosFil: Huntsman, Molly M.. University Of Georgetown; Estados UnidosFil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados UnidosNature Publishing Group2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20755Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-1491097-62561546-1726CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/neuro/journal/v12/n2/full/nn.2241.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nn.2241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:20:58Zoai:ri.conicet.gov.ar:11336/20755instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:20:59.072CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
title Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
spellingShingle Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
Hirata, Tsutomu
Amigdala
Development
Transcription Factor
Thelencephalon
title_short Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
title_full Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
title_fullStr Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
title_full_unstemmed Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
title_sort Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
dc.creator.none.fl_str_mv Hirata, Tsutomu
Li, Peijun
Lanuza, Guillermo Marcos
Cocas, Laura A.
Huntsman, Molly M.
Corbin, Joshua G.
author Hirata, Tsutomu
author_facet Hirata, Tsutomu
Li, Peijun
Lanuza, Guillermo Marcos
Cocas, Laura A.
Huntsman, Molly M.
Corbin, Joshua G.
author_role author
author2 Li, Peijun
Lanuza, Guillermo Marcos
Cocas, Laura A.
Huntsman, Molly M.
Corbin, Joshua G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Amigdala
Development
Transcription Factor
Thelencephalon
topic Amigdala
Development
Transcription Factor
Thelencephalon
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
Fil: Li, Peijun. University Of Georgetown; Estados Unidos
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados Unidos
Fil: Huntsman, Molly M.. University Of Georgetown; Estados Unidos
Fil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
description The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
publishDate 2009
dc.date.none.fl_str_mv 2009-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20755
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149
1097-6256
1546-1726
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20755
identifier_str_mv Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149
1097-6256
1546-1726
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/neuro/journal/v12/n2/full/nn.2241.html
info:eu-repo/semantics/altIdentifier/doi/10.1038/nn.2241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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