Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
- Autores
- Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; Corbin, Joshua G.
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.
Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos
Fil: Li, Peijun. University Of Georgetown; Estados Unidos
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados Unidos
Fil: Huntsman, Molly M.. University Of Georgetown; Estados Unidos
Fil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos - Materia
-
Amigdala
Development
Transcription Factor
Thelencephalon - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/20755
Ver los metadatos del registro completo
id |
CONICETDig_d1408988421e502a2e15e09d32b70794 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/20755 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdalaHirata, TsutomuLi, PeijunLanuza, Guillermo MarcosCocas, Laura A.Huntsman, Molly M.Corbin, Joshua G.AmigdalaDevelopmentTranscription FactorThelencephalonhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system.Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados UnidosFil: Li, Peijun. University Of Georgetown; Estados UnidosFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados UnidosFil: Huntsman, Molly M.. University Of Georgetown; Estados UnidosFil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados UnidosNature Publishing Group2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20755Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-1491097-62561546-1726CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/neuro/journal/v12/n2/full/nn.2241.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nn.2241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:20:58Zoai:ri.conicet.gov.ar:11336/20755instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:20:59.072CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
title |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
spellingShingle |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala Hirata, Tsutomu Amigdala Development Transcription Factor Thelencephalon |
title_short |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
title_full |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
title_fullStr |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
title_full_unstemmed |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
title_sort |
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala |
dc.creator.none.fl_str_mv |
Hirata, Tsutomu Li, Peijun Lanuza, Guillermo Marcos Cocas, Laura A. Huntsman, Molly M. Corbin, Joshua G. |
author |
Hirata, Tsutomu |
author_facet |
Hirata, Tsutomu Li, Peijun Lanuza, Guillermo Marcos Cocas, Laura A. Huntsman, Molly M. Corbin, Joshua G. |
author_role |
author |
author2 |
Li, Peijun Lanuza, Guillermo Marcos Cocas, Laura A. Huntsman, Molly M. Corbin, Joshua G. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Amigdala Development Transcription Factor Thelencephalon |
topic |
Amigdala Development Transcription Factor Thelencephalon |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system. Fil: Hirata, Tsutomu. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos Fil: Li, Peijun. University Of Georgetown; Estados Unidos Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Cocas, Laura A.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos. University Of Georgetown; Estados Unidos Fil: Huntsman, Molly M.. University Of Georgetown; Estados Unidos Fil: Corbin, Joshua G.. Children’s National Medical Center. Center for Neuroscience Research; Estados Unidos |
description |
The development of the amygdala, a central structure of the limbic system, remains poorly understood. We found that two spatially distinct and early-specified telencephalic progenitor pools marked by the homeodomain transcription factor Dbx1 are major sources of neuronal cell diversity in the mature mouse amygdala. We found that Dbx1-positive cells of the ventral pallium generate the excitatory neurons of the basolateral complex and cortical amygdala nuclei. Moreover, Dbx1-derived cells comprise a previously unknown migratory stream that emanates from the preoptic area (POA), a ventral telencephalic domain adjacent to the diencephalic border. The Dbx1-positive, POA-derived population migrated specifically to the amygdala and, as defined by both immunochemical and electrophysiological criteria, generated a unique subclass of inhibitory neurons in the medial amygdala nucleus. Thus, this POA-derived population represents a previously unknown progenitor pool dedicated to the limbic system. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/20755 Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149 1097-6256 1546-1726 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/20755 |
identifier_str_mv |
Hirata, Tsutomu; Li, Peijun; Lanuza, Guillermo Marcos; Cocas, Laura A.; Huntsman, Molly M.; et al.; Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala; Nature Publishing Group; Nature Neuroscience.; 12; 2; 2-2009; 141-149 1097-6256 1546-1726 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/neuro/journal/v12/n2/full/nn.2241.html info:eu-repo/semantics/altIdentifier/doi/10.1038/nn.2241 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846782661377392640 |
score |
12.982451 |