Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness
- Autores
- Mitra, Anish; Snyder, Abraham Z.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Elison, Jed; Emerson, Robert W.; Shen, Mark D.; Wolff, Jason J.; Botteron, Kelly N.; Dager, Stephen; Estes, Annette M.; Evans, A.C.; Gerig, Guido; Hazlett, Heather C.; Paterson, Sarah J.; Schultz, Robert T.; Styner, Martin A.; Zwaigenbaum, Lonnie; Chappell, C.; Estes, A.; Shaw, D.; Botteron, K.; McKinstry, R.; Constantino, J.; Pruett, J.; Schultz, R.; Paterson, S.; Collins, D.L.; Pike, G.B.; Fonov, V.; Kostopoulos, P.; Dasso, Sergio Alberto; Styner, M.; Gu, H.; Schlaggar, Bradley L.; Piven, Joseph; Pruett, John R.; Raichle, Marcus
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.
Fil: Mitra, Anish. Washington University School Of Medicine In St. Louis; Estados Unidos
Fil: Snyder, Abraham Z.. Washington University School Of Medicine In St. Louis; Estados Unidos
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Laufs, Helmut. Christian-albrechts-universitat Zu Kiel; Alemania
Fil: Elison, Jed. University of Minnesota; Estados Unidos
Fil: Emerson, Robert W.. University of North Carolina; Estados Unidos
Fil: Shen, Mark D.. University of North Carolina; Estados Unidos
Fil: Wolff, Jason J.. University of Minnesota; Estados Unidos
Fil: Botteron, Kelly N.. Washington University School Of Medicine In St. Louis; Estados Unidos
Fil: Dager, Stephen. University Of Washington, Seattle; Estados Unidos
Fil: Estes, Annette M.. University Of Washington, Seattle; Estados Unidos
Fil: Evans, A.C.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Gerig, Guido. University of New York; Estados Unidos
Fil: Hazlett, Heather C.. University of North Carolina; Estados Unidos
Fil: Paterson, Sarah J.. University of Pennsylvania; Estados Unidos
Fil: Schultz, Robert T.. University of Pennsylvania; Estados Unidos
Fil: Styner, Martin A.. University of North Carolina; Estados Unidos
Fil: Zwaigenbaum, Lonnie. University of Alberta; Canadá
Fil: Chappell, C.. Ibis Network Pi; Estados Unidos
Fil: Estes, A.. University Of Washington, Seattle; Estados Unidos
Fil: Shaw, D.. University Of Washington, Seattle; Estados Unidos
Fil: Botteron, K.. University Of Washington, Seattle; Estados Unidos
Fil: McKinstry, R.. University Of Washington, Seattle; Estados Unidos
Fil: Constantino, J.. University Of Washington, Seattle; Estados Unidos
Fil: Pruett, J.. University Of Washington, Seattle; Estados Unidos
Fil: Schultz, R.. The Children?s Hospital Of Philadelphia; Estados Unidos
Fil: Paterson, S.. The Children?s Hospital Of Philadelphia; Estados Unidos
Fil: Collins, D.L.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Pike, G.B.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Fonov, V.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Kostopoulos, P.. McGill University. Montreal Neurological Institute and Hospital; Canadá
Fil: Dasso, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: Styner, M.. The University Of North Carolina System; Estados Unidos
Fil: Gu, H.. Statistical Analysis Core; Estados Unidos
Fil: Schlaggar, Bradley L.. Washington University School Of Medicine In St. Louis; Estados Unidos
Fil: Piven, Joseph. University of North Carolina; Estados Unidos
Fil: Pruett, John R.. Washington University School Of Medicine In St. Louis; Estados Unidos
Fil: Raichle, Marcus. Washington University School Of Medicine In St. Louis; Estados Unidos - Materia
-
SLEEP
NEUROIMAGING
DEVELOPMENT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/64737
Ver los metadatos del registro completo
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Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulnessMitra, AnishSnyder, Abraham Z.Tagliazucchi, Enzo RodolfoLaufs, HelmutElison, JedEmerson, Robert W.Shen, Mark D.Wolff, Jason J.Botteron, Kelly N.Dager, StephenEstes, Annette M.Evans, A.C.Gerig, GuidoHazlett, Heather C.Paterson, Sarah J.Schultz, Robert T.Styner, Martin A.Zwaigenbaum, LonnieChappell, C.Estes, A.Shaw, D.Botteron, K.McKinstry, R.Constantino, J.Pruett, J.Schultz, R.Paterson, S.Collins, D.L.Pike, G.B.Fonov, V.Kostopoulos, P.Dasso, Sergio AlbertoStyner, M.Gu, H.Schlaggar, Bradley L.Piven, JosephPruett, John R.Raichle, MarcusSLEEPNEUROIMAGINGDEVELOPMENThttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI.Fil: Mitra, Anish. Washington University School Of Medicine In St. Louis; Estados UnidosFil: Snyder, Abraham Z.. Washington University School Of Medicine In St. Louis; Estados UnidosFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Laufs, Helmut. Christian-albrechts-universitat Zu Kiel; AlemaniaFil: Elison, Jed. University of Minnesota; Estados UnidosFil: Emerson, Robert W.. University of North Carolina; Estados UnidosFil: Shen, Mark D.. University of North Carolina; Estados UnidosFil: Wolff, Jason J.. University of Minnesota; Estados UnidosFil: Botteron, Kelly N.. Washington University School Of Medicine In St. Louis; Estados UnidosFil: Dager, Stephen. University Of Washington, Seattle; Estados UnidosFil: Estes, Annette M.. University Of Washington, Seattle; Estados UnidosFil: Evans, A.C.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Gerig, Guido. University of New York; Estados UnidosFil: Hazlett, Heather C.. University of North Carolina; Estados UnidosFil: Paterson, Sarah J.. University of Pennsylvania; Estados UnidosFil: Schultz, Robert T.. University of Pennsylvania; Estados UnidosFil: Styner, Martin A.. University of North Carolina; Estados UnidosFil: Zwaigenbaum, Lonnie. University of Alberta; CanadáFil: Chappell, C.. Ibis Network Pi; Estados UnidosFil: Estes, A.. University Of Washington, Seattle; Estados UnidosFil: Shaw, D.. University Of Washington, Seattle; Estados UnidosFil: Botteron, K.. University Of Washington, Seattle; Estados UnidosFil: McKinstry, R.. University Of Washington, Seattle; Estados UnidosFil: Constantino, J.. University Of Washington, Seattle; Estados UnidosFil: Pruett, J.. University Of Washington, Seattle; Estados UnidosFil: Schultz, R.. The Children?s Hospital Of Philadelphia; Estados UnidosFil: Paterson, S.. The Children?s Hospital Of Philadelphia; Estados UnidosFil: Collins, D.L.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Pike, G.B.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Fonov, V.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Kostopoulos, P.. McGill University. Montreal Neurological Institute and Hospital; CanadáFil: Dasso, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: Styner, M.. The University Of North Carolina System; Estados UnidosFil: Gu, H.. Statistical Analysis Core; Estados UnidosFil: Schlaggar, Bradley L.. Washington University School Of Medicine In St. Louis; Estados UnidosFil: Piven, Joseph. University of North Carolina; Estados UnidosFil: Pruett, John R.. Washington University School Of Medicine In St. Louis; Estados UnidosFil: Raichle, Marcus. Washington University School Of Medicine In St. Louis; Estados UnidosPublic Library of Science2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64737Mitra, Anish; Snyder, Abraham Z.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Elison, Jed; et al.; Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness; Public Library of Science; Plos One; 12; 11; 11-2017; 1-111932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0188122info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:36Zoai:ri.conicet.gov.ar:11336/64737instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:36.974CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| spellingShingle |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness Mitra, Anish SLEEP NEUROIMAGING DEVELOPMENT |
| title_short |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_full |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_fullStr |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_full_unstemmed |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| title_sort |
Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness |
| dc.creator.none.fl_str_mv |
Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Rodolfo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, A.C. Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Chappell, C. Estes, A. Shaw, D. Botteron, K. McKinstry, R. Constantino, J. Pruett, J. Schultz, R. Paterson, S. Collins, D.L. Pike, G.B. Fonov, V. Kostopoulos, P. Dasso, Sergio Alberto Styner, M. Gu, H. Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus |
| author |
Mitra, Anish |
| author_facet |
Mitra, Anish Snyder, Abraham Z. Tagliazucchi, Enzo Rodolfo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, A.C. Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Chappell, C. Estes, A. Shaw, D. Botteron, K. McKinstry, R. Constantino, J. Pruett, J. Schultz, R. Paterson, S. Collins, D.L. Pike, G.B. Fonov, V. Kostopoulos, P. Dasso, Sergio Alberto Styner, M. Gu, H. Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus |
| author_role |
author |
| author2 |
Snyder, Abraham Z. Tagliazucchi, Enzo Rodolfo Laufs, Helmut Elison, Jed Emerson, Robert W. Shen, Mark D. Wolff, Jason J. Botteron, Kelly N. Dager, Stephen Estes, Annette M. Evans, A.C. Gerig, Guido Hazlett, Heather C. Paterson, Sarah J. Schultz, Robert T. Styner, Martin A. Zwaigenbaum, Lonnie Chappell, C. Estes, A. Shaw, D. Botteron, K. McKinstry, R. Constantino, J. Pruett, J. Schultz, R. Paterson, S. Collins, D.L. Pike, G.B. Fonov, V. Kostopoulos, P. Dasso, Sergio Alberto Styner, M. Gu, H. Schlaggar, Bradley L. Piven, Joseph Pruett, John R. Raichle, Marcus |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
SLEEP NEUROIMAGING DEVELOPMENT |
| topic |
SLEEP NEUROIMAGING DEVELOPMENT |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.3 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. Fil: Mitra, Anish. Washington University School Of Medicine In St. Louis; Estados Unidos Fil: Snyder, Abraham Z.. Washington University School Of Medicine In St. Louis; Estados Unidos Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Laufs, Helmut. Christian-albrechts-universitat Zu Kiel; Alemania Fil: Elison, Jed. University of Minnesota; Estados Unidos Fil: Emerson, Robert W.. University of North Carolina; Estados Unidos Fil: Shen, Mark D.. University of North Carolina; Estados Unidos Fil: Wolff, Jason J.. University of Minnesota; Estados Unidos Fil: Botteron, Kelly N.. Washington University School Of Medicine In St. Louis; Estados Unidos Fil: Dager, Stephen. University Of Washington, Seattle; Estados Unidos Fil: Estes, Annette M.. University Of Washington, Seattle; Estados Unidos Fil: Evans, A.C.. McGill University. Montreal Neurological Institute and Hospital; Canadá Fil: Gerig, Guido. University of New York; Estados Unidos Fil: Hazlett, Heather C.. University of North Carolina; Estados Unidos Fil: Paterson, Sarah J.. University of Pennsylvania; Estados Unidos Fil: Schultz, Robert T.. University of Pennsylvania; Estados Unidos Fil: Styner, Martin A.. University of North Carolina; Estados Unidos Fil: Zwaigenbaum, Lonnie. University of Alberta; Canadá Fil: Chappell, C.. Ibis Network Pi; Estados Unidos Fil: Estes, A.. University Of Washington, Seattle; Estados Unidos Fil: Shaw, D.. University Of Washington, Seattle; Estados Unidos Fil: Botteron, K.. University Of Washington, Seattle; Estados Unidos Fil: McKinstry, R.. University Of Washington, Seattle; Estados Unidos Fil: Constantino, J.. University Of Washington, Seattle; Estados Unidos Fil: Pruett, J.. University Of Washington, Seattle; Estados Unidos Fil: Schultz, R.. The Children?s Hospital Of Philadelphia; Estados Unidos Fil: Paterson, S.. The Children?s Hospital Of Philadelphia; Estados Unidos Fil: Collins, D.L.. McGill University. Montreal Neurological Institute and Hospital; Canadá Fil: Pike, G.B.. McGill University. Montreal Neurological Institute and Hospital; Canadá Fil: Fonov, V.. McGill University. Montreal Neurological Institute and Hospital; Canadá Fil: Kostopoulos, P.. McGill University. Montreal Neurological Institute and Hospital; Canadá Fil: Dasso, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina Fil: Styner, M.. The University Of North Carolina System; Estados Unidos Fil: Gu, H.. Statistical Analysis Core; Estados Unidos Fil: Schlaggar, Bradley L.. Washington University School Of Medicine In St. Louis; Estados Unidos Fil: Piven, Joseph. University of North Carolina; Estados Unidos Fil: Pruett, John R.. Washington University School Of Medicine In St. Louis; Estados Unidos Fil: Raichle, Marcus. Washington University School Of Medicine In St. Louis; Estados Unidos |
| description |
Resting state functional magnetic resonance imaging (rs-fMRI) in infants enables important studies of functional brain organization early in human development. However, rs-fMRI in infants has universally been obtained during sleep to reduce participant motion artifact, raising the question of whether differences in functional organization between awake adults and sleeping infants that are commonly attributed to development may instead derive, at least in part, from sleep. This question is especially important as rs-fMRI differences in adult wake vs. sleep are well documented. To investigate this question, we compared functional connectivity and BOLD signal propagation patterns in 6, 12, and 24 month old sleeping infants with patterns in adult wakefulness and non-REM sleep. We find that important functional connectivity features seen during infant sleep closely resemble those seen during adult sleep, including reduced default mode network functional connectivity. However, we also find differences between infant and adult sleep, especially in thalamic BOLD signal propagation patterns. These findings highlight the importance of considering sleep state when drawing developmental inferences in infant rs-fMRI. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-11 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/64737 Mitra, Anish; Snyder, Abraham Z.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Elison, Jed; et al.; Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness; Public Library of Science; Plos One; 12; 11; 11-2017; 1-11 1932-6203 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/64737 |
| identifier_str_mv |
Mitra, Anish; Snyder, Abraham Z.; Tagliazucchi, Enzo Rodolfo; Laufs, Helmut; Elison, Jed; et al.; Resting-state fMRI in sleeping infants more closely resembles adult sleep than adult wakefulness; Public Library of Science; Plos One; 12; 11; 11-2017; 1-11 1932-6203 CONICET Digital CONICET |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0188122 |
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