Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation

Autores
León Vargas, Fabian; Garelli, Fabricio; de Battista, Hernan; Vehí, Josep
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints. A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation. The robust performance ofthe control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances.
Fil: León Vargas, Fabian. Universidad de Girona; España
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: de Battista, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: Vehí, Josep. Universidad de Girona; España
Materia
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Sliding Mode Control
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23045
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitationLeón Vargas, FabianGarelli, Fabriciode Battista, HernanVehí, JosepArtificial PancreasGlucose ControlHypoglycemiaInsulin-On-BoardConstrained ControlSliding Mode Controlhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints. A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation. The robust performance ofthe control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances.Fil: León Vargas, Fabian. Universidad de Girona; EspañaFil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; ArgentinaFil: de Battista, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; ArgentinaFil: Vehí, Josep. Universidad de Girona; EspañaElsevier2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23045León Vargas, Fabian; Garelli, Fabricio; de Battista, Hernan; Vehí, Josep; Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation; Elsevier; Biomedical Signal Processing And Control; 8; 6; 8-2013; 724-7361746-8094CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2013.06.008info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809413000931info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:27Zoai:ri.conicet.gov.ar:11336/23045instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:28.192CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
title Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
spellingShingle Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
León Vargas, Fabian
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Sliding Mode Control
title_short Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
title_full Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
title_fullStr Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
title_full_unstemmed Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
title_sort Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation
dc.creator.none.fl_str_mv León Vargas, Fabian
Garelli, Fabricio
de Battista, Hernan
Vehí, Josep
author León Vargas, Fabian
author_facet León Vargas, Fabian
Garelli, Fabricio
de Battista, Hernan
Vehí, Josep
author_role author
author2 Garelli, Fabricio
de Battista, Hernan
Vehí, Josep
author2_role author
author
author
dc.subject.none.fl_str_mv Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Sliding Mode Control
topic Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Sliding Mode Control
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints. A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation. The robust performance ofthe control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances.
Fil: León Vargas, Fabian. Universidad de Girona; España
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: de Battista, Hernan. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ingeniería. Departamento de Electrotecnia. Laboratorio de Electrónica Industrial, Control e Instrumentación; Argentina
Fil: Vehí, Josep. Universidad de Girona; España
description This paper addresses the design of blood glucose control during the postprandial period for Type 1 diabetes patients. An artificial pancreas for ambulatory purposes has to deal with the delays inherent to the subcutaneous route, the carbohydrate intakes, the metabolic changes, the glucose sensor errors and noise, and the insulin pump constraints. A time response typically obtained in closed-loop insulin delivery shows hyperglycemia in the early postprandial period caused by the lag in the insulin absorbtion, followed by hypoglycemia caused by control over-reaction. A hybrid control system is proposed in this paper to overcome these problems. An insulin bolus is administered prior to the meals like in open-loop control, whereas a PD controller is used for robust glucose regulation. The controller gain is progressively increased after the bolus from zero up to its nominal value as function of the insulin on board, so that the PD controller becomes fully operational just when the insulin on board falls below a prescribed value. An excessive accumulation of active insulin is avoided in this way, drastically reducing the risk of hypoglycemia. The controller gain is adapted by means of a variable structure algorithm, allowing a very simple software implementation. The robust performance ofthe control algorithm is intensively assessed in silico on a cohort of virtual patients under challenging realistic scenarios considering mixed meals, circadian variations, time-varying uncertainties, discrete measurement and actuation, sensor errors and other disturbances.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23045
León Vargas, Fabian; Garelli, Fabricio; de Battista, Hernan; Vehí, Josep; Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation; Elsevier; Biomedical Signal Processing And Control; 8; 6; 8-2013; 724-736
1746-8094
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23045
identifier_str_mv León Vargas, Fabian; Garelli, Fabricio; de Battista, Hernan; Vehí, Josep; Postprandial blood glucose control using a hybrid adaptive PD controller with insulin-on-board limitation; Elsevier; Biomedical Signal Processing And Control; 8; 6; 8-2013; 724-736
1746-8094
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2013.06.008
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809413000931
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269959658405888
score 13.13397

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