Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes

Autores
Revert, A.; Garelli, Fabricio; Picó, J.; de Battista, Hernán; Rossetti, P.; Vehi, J.; Bondia, J.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the arti- ficial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.
Fil: Revert, A.. Universidad Politécnica de Valencia; España
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina
Fil: Picó, J.. Universidad Politécnica de Valencia; España
Fil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina
Fil: Rossetti, P.. Universidad Politécnica de Valencia; España
Fil: Vehi, J.. Universidad de Girona; España
Fil: Bondia, J.. Universidad Politécnica de Valencia; España
Materia
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Reference Conditioning
Safety
Sliding Mode (Sm)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23533
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Safety auxiliary feedback element for the artificial pancreas in type 1 diabetesRevert, A.Garelli, FabricioPicó, J.de Battista, HernánRossetti, P.Vehi, J.Bondia, J.Artificial PancreasGlucose ControlHypoglycemiaInsulin-On-BoardReference ConditioningSafetySliding Mode (Sm)https://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the arti- ficial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.Fil: Revert, A.. Universidad Politécnica de Valencia; EspañaFil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; ArgentinaFil: Picó, J.. Universidad Politécnica de Valencia; EspañaFil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; ArgentinaFil: Rossetti, P.. Universidad Politécnica de Valencia; EspañaFil: Vehi, J.. Universidad de Girona; EspañaFil: Bondia, J.. Universidad Politécnica de Valencia; EspañaInstitute of Electrical and Electronics Engineers2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23533Revert, A.; Garelli, Fabricio; Picó, J.; de Battista, Hernán; Rossetti, P.; et al.; Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 60; 8; 3-2013; 2113-21220018-9294CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1109/TBME.2013.2247602info:eu-repo/semantics/altIdentifier/url/http://ieeexplore.ieee.org/document/6463437/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:11Zoai:ri.conicet.gov.ar:11336/23533instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:11.53CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
title Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
spellingShingle Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
Revert, A.
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Reference Conditioning
Safety
Sliding Mode (Sm)
title_short Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
title_full Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
title_fullStr Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
title_full_unstemmed Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
title_sort Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes
dc.creator.none.fl_str_mv Revert, A.
Garelli, Fabricio
Picó, J.
de Battista, Hernán
Rossetti, P.
Vehi, J.
Bondia, J.
author Revert, A.
author_facet Revert, A.
Garelli, Fabricio
Picó, J.
de Battista, Hernán
Rossetti, P.
Vehi, J.
Bondia, J.
author_role author
author2 Garelli, Fabricio
Picó, J.
de Battista, Hernán
Rossetti, P.
Vehi, J.
Bondia, J.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Reference Conditioning
Safety
Sliding Mode (Sm)
topic Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Reference Conditioning
Safety
Sliding Mode (Sm)
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the arti- ficial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.
Fil: Revert, A.. Universidad Politécnica de Valencia; España
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina
Fil: Picó, J.. Universidad Politécnica de Valencia; España
Fil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ingeniería; Argentina
Fil: Rossetti, P.. Universidad Politécnica de Valencia; España
Fil: Vehi, J.. Universidad de Girona; España
Fil: Bondia, J.. Universidad Politécnica de Valencia; España
description The artificial pancreas aims at the automatic delivery of insulin for glycemic control in patients with type 1 diabetes, i.e., closed-loop glucose control. One of the challenges of the arti- ficial pancreas is to avoid controller overreaction leading to hypoglycemia, especially in the late postprandial period. In this study, an original proposal based on sliding mode reference conditioning ideas is presented as a way to reduce hypoglycemia events induced by a closed-loop glucose controller. The method is inspired in the intuitive advantages of two-step constrained control algorithms. It acts on the glucose reference sent to the main controller shaping it so as to avoid violating given constraints on the insulin-on-board. Some distinctive features of the proposed strategy are that 1) it provides a safety layer which can be adjusted according to medical criteria; 2) it can be added to closed-loop controllers of any nature; 3) it is robust against sensor failures and overestimated prandial insulin doses; and 4) it can handle nonlinear models. The method is evaluated in silico with the ten adult patients available in the FDA-accepted UVA simulator.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23533
Revert, A.; Garelli, Fabricio; Picó, J.; de Battista, Hernán; Rossetti, P.; et al.; Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 60; 8; 3-2013; 2113-2122
0018-9294
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23533
identifier_str_mv Revert, A.; Garelli, Fabricio; Picó, J.; de Battista, Hernán; Rossetti, P.; et al.; Safety auxiliary feedback element for the artificial pancreas in type 1 diabetes; Institute of Electrical and Electronics Engineers; Ieee Transactions On Bio-medical Engineering; 60; 8; 3-2013; 2113-2122
0018-9294
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1109/TBME.2013.2247602
info:eu-repo/semantics/altIdentifier/url/http://ieeexplore.ieee.org/document/6463437/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269329097228288
score 13.13397

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