Postprandial response improvement via safety layer in closed-loop blood glucose controllers

Autores
León Vargas, Fabián; Garelli, Fabricio; de Battista, Hernán; Vehí, Josep
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.
Fil: León Vargas, Fabián. Universidad Antonio Nariño; Colombia
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Vehí, Josep. Universidad de Girona; España
Materia
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Postprandial
Sliding Mode Control
Safety Layer
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33271
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/33271
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Postprandial response improvement via safety layer in closed-loop blood glucose controllersLeón Vargas, FabiánGarelli, Fabriciode Battista, HernánVehí, JosepArtificial PancreasGlucose ControlHypoglycemiaInsulin-On-BoardConstrained ControlPostprandialSliding Mode ControlSafety Layerhttps://purl.org/becyt/ford/2.2https://purl.org/becyt/ford/2Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.Fil: León Vargas, Fabián. Universidad Antonio Nariño; ColombiaFil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Vehí, Josep. Universidad de Girona; EspañaElsevier2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33271de Battista, Hernán; Garelli, Fabricio; León Vargas, Fabián; Vehí, Josep; Postprandial response improvement via safety layer in closed-loop blood glucose controllers; Elsevier; Biomedical Signal Processing and Control; 16; 11-2014; 80-871746-8094CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2014.10.003info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809414001529info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:33Zoai:ri.conicet.gov.ar:11336/33271instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:33.908CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Postprandial response improvement via safety layer in closed-loop blood glucose controllers
title Postprandial response improvement via safety layer in closed-loop blood glucose controllers
spellingShingle Postprandial response improvement via safety layer in closed-loop blood glucose controllers
León Vargas, Fabián
Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Postprandial
Sliding Mode Control
Safety Layer
title_short Postprandial response improvement via safety layer in closed-loop blood glucose controllers
title_full Postprandial response improvement via safety layer in closed-loop blood glucose controllers
title_fullStr Postprandial response improvement via safety layer in closed-loop blood glucose controllers
title_full_unstemmed Postprandial response improvement via safety layer in closed-loop blood glucose controllers
title_sort Postprandial response improvement via safety layer in closed-loop blood glucose controllers
dc.creator.none.fl_str_mv León Vargas, Fabián
Garelli, Fabricio
de Battista, Hernán
Vehí, Josep
author León Vargas, Fabián
author_facet León Vargas, Fabián
Garelli, Fabricio
de Battista, Hernán
Vehí, Josep
author_role author
author2 Garelli, Fabricio
de Battista, Hernán
Vehí, Josep
author2_role author
author
author
dc.subject.none.fl_str_mv Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Postprandial
Sliding Mode Control
Safety Layer
topic Artificial Pancreas
Glucose Control
Hypoglycemia
Insulin-On-Board
Constrained Control
Postprandial
Sliding Mode Control
Safety Layer
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.2
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.
Fil: León Vargas, Fabián. Universidad Antonio Nariño; Colombia
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Vehí, Josep. Universidad de Girona; España
description Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33271
de Battista, Hernán; Garelli, Fabricio; León Vargas, Fabián; Vehí, Josep; Postprandial response improvement via safety layer in closed-loop blood glucose controllers; Elsevier; Biomedical Signal Processing and Control; 16; 11-2014; 80-87
1746-8094
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33271
identifier_str_mv de Battista, Hernán; Garelli, Fabricio; León Vargas, Fabián; Vehí, Josep; Postprandial response improvement via safety layer in closed-loop blood glucose controllers; Elsevier; Biomedical Signal Processing and Control; 16; 11-2014; 80-87
1746-8094
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bspc.2014.10.003
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809414001529
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268929952579584
score 12.885934

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