Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile
- Autores
- Lorenzo Bermejo, Justo; Boekstegers, Felix; González Silos, Rosa; Marcelain, Katherine; Baez Benavides, Pablo; Barahona Ponce, Carol; Müller, Bettina; Ferreccio, Catterina; Koshiol, Jill; Fischer, Christine; Peil, Barbara; Sinsheimer, Janet; Fuentes Guajardo, Macarena; Barajas, Olga; González José, Rolando; Bedoya, Gabriel; Bortolini, Maria Catira; Canizales Quinteros, Samuel; Gallo, Carla; Ruiz Linares, Andres; Rothhammer, Francisco
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1–4.3%, P = 6×10−27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data.
Fil: Lorenzo Bermejo, Justo. University of Heidelberg; Alemania
Fil: Boekstegers, Felix. University of Heidelberg; Alemania
Fil: González Silos, Rosa. University of Heidelberg; Alemania
Fil: Marcelain, Katherine. Universidad de Chile; Chile
Fil: Baez Benavides, Pablo. Universidad de Chile; Chile
Fil: Barahona Ponce, Carol. University of Heidelberg; Alemania. Universidad de Chile; Chile
Fil: Müller, Bettina. Instituto Nacional del Cáncer de Chile; Chile
Fil: Ferreccio, Catterina. Pontificia Universidad Católica de Chile; Chile. Advanced Center for Chronic Diseases; Chile
Fil: Koshiol, Jill. National Cancer Institute; Estados Unidos
Fil: Fischer, Christine. University of Heidelberg; Alemania
Fil: Peil, Barbara. University of Heidelberg; Alemania
Fil: Sinsheimer, Janet. University Of California At Los Angeles. School Of Medicine; Estados Unidos
Fil: Fuentes Guajardo, Macarena. Tarapacá University; Chile. Colegio Universitario de Londres; Reino Unido
Fil: Barajas, Olga. Universidad de Chile; Chile
Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Ruiz Linares, Andres. Colegio Universitario de Londres; Reino Unido
Fil: Rothhammer, Francisco. Tarapacá University; Chile - Materia
-
ANCESTRIA
CHILE
CANCER DE VESICULA
GENOMICA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/40051
Ver los metadatos del registro completo
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Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in ChileLorenzo Bermejo, JustoBoekstegers, FelixGonzález Silos, RosaMarcelain, KatherineBaez Benavides, PabloBarahona Ponce, CarolMüller, BettinaFerreccio, CatterinaKoshiol, JillFischer, ChristinePeil, BarbaraSinsheimer, JanetFuentes Guajardo, MacarenaBarajas, OlgaGonzález José, RolandoBedoya, GabrielBortolini, Maria CatiraCanizales Quinteros, SamuelGallo, CarlaRuiz Linares, AndresRothhammer, FranciscoANCESTRIACHILECANCER DE VESICULAGENOMICAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1–4.3%, P = 6×10−27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data.Fil: Lorenzo Bermejo, Justo. University of Heidelberg; AlemaniaFil: Boekstegers, Felix. University of Heidelberg; AlemaniaFil: González Silos, Rosa. University of Heidelberg; AlemaniaFil: Marcelain, Katherine. Universidad de Chile; ChileFil: Baez Benavides, Pablo. Universidad de Chile; ChileFil: Barahona Ponce, Carol. University of Heidelberg; Alemania. Universidad de Chile; ChileFil: Müller, Bettina. Instituto Nacional del Cáncer de Chile; ChileFil: Ferreccio, Catterina. Pontificia Universidad Católica de Chile; Chile. Advanced Center for Chronic Diseases; ChileFil: Koshiol, Jill. National Cancer Institute; Estados UnidosFil: Fischer, Christine. University of Heidelberg; AlemaniaFil: Peil, Barbara. University of Heidelberg; AlemaniaFil: Sinsheimer, Janet. University Of California At Los Angeles. School Of Medicine; Estados UnidosFil: Fuentes Guajardo, Macarena. Tarapacá University; Chile. Colegio Universitario de Londres; Reino UnidoFil: Barajas, Olga. Universidad de Chile; ChileFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; ArgentinaFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; BrasilFil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Ruiz Linares, Andres. Colegio Universitario de Londres; Reino UnidoFil: Rothhammer, Francisco. Tarapacá University; ChilePublic Library of Science2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40051Lorenzo Bermejo, Justo; Boekstegers, Felix; González Silos, Rosa; Marcelain, Katherine; Baez Benavides, Pablo; et al.; Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile; Public Library of Science; Plos Genetics; 13; 5; 5-2017; e10067561553-7390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1006756info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:10:35Zoai:ri.conicet.gov.ar:11336/40051instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:10:35.651CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| title |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| spellingShingle |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile Lorenzo Bermejo, Justo ANCESTRIA CHILE CANCER DE VESICULA GENOMICA |
| title_short |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| title_full |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| title_fullStr |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| title_full_unstemmed |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| title_sort |
Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile |
| dc.creator.none.fl_str_mv |
Lorenzo Bermejo, Justo Boekstegers, Felix González Silos, Rosa Marcelain, Katherine Baez Benavides, Pablo Barahona Ponce, Carol Müller, Bettina Ferreccio, Catterina Koshiol, Jill Fischer, Christine Peil, Barbara Sinsheimer, Janet Fuentes Guajardo, Macarena Barajas, Olga González José, Rolando Bedoya, Gabriel Bortolini, Maria Catira Canizales Quinteros, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco |
| author |
Lorenzo Bermejo, Justo |
| author_facet |
Lorenzo Bermejo, Justo Boekstegers, Felix González Silos, Rosa Marcelain, Katherine Baez Benavides, Pablo Barahona Ponce, Carol Müller, Bettina Ferreccio, Catterina Koshiol, Jill Fischer, Christine Peil, Barbara Sinsheimer, Janet Fuentes Guajardo, Macarena Barajas, Olga González José, Rolando Bedoya, Gabriel Bortolini, Maria Catira Canizales Quinteros, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco |
| author_role |
author |
| author2 |
Boekstegers, Felix González Silos, Rosa Marcelain, Katherine Baez Benavides, Pablo Barahona Ponce, Carol Müller, Bettina Ferreccio, Catterina Koshiol, Jill Fischer, Christine Peil, Barbara Sinsheimer, Janet Fuentes Guajardo, Macarena Barajas, Olga González José, Rolando Bedoya, Gabriel Bortolini, Maria Catira Canizales Quinteros, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ANCESTRIA CHILE CANCER DE VESICULA GENOMICA |
| topic |
ANCESTRIA CHILE CANCER DE VESICULA GENOMICA |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1–4.3%, P = 6×10−27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data. Fil: Lorenzo Bermejo, Justo. University of Heidelberg; Alemania Fil: Boekstegers, Felix. University of Heidelberg; Alemania Fil: González Silos, Rosa. University of Heidelberg; Alemania Fil: Marcelain, Katherine. Universidad de Chile; Chile Fil: Baez Benavides, Pablo. Universidad de Chile; Chile Fil: Barahona Ponce, Carol. University of Heidelberg; Alemania. Universidad de Chile; Chile Fil: Müller, Bettina. Instituto Nacional del Cáncer de Chile; Chile Fil: Ferreccio, Catterina. Pontificia Universidad Católica de Chile; Chile. Advanced Center for Chronic Diseases; Chile Fil: Koshiol, Jill. National Cancer Institute; Estados Unidos Fil: Fischer, Christine. University of Heidelberg; Alemania Fil: Peil, Barbara. University of Heidelberg; Alemania Fil: Sinsheimer, Janet. University Of California At Los Angeles. School Of Medicine; Estados Unidos Fil: Fuentes Guajardo, Macarena. Tarapacá University; Chile. Colegio Universitario de Londres; Reino Unido Fil: Barajas, Olga. Universidad de Chile; Chile Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Nacional Patagónico; Argentina Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Ruiz Linares, Andres. Colegio Universitario de Londres; Reino Unido Fil: Rothhammer, Francisco. Tarapacá University; Chile |
| description |
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls. Native American proportions were markedly underestimated when the two main types of Native American ancestry in Chile, originated from the Mapuche and Aymara indigenous peoples, were combined together. Consideration of the type of Native American ancestry was crucial to identify disease associations. Native American ancestry showed no association with gallbladder cancer mortality (P = 0.26). By contrast, each 1% increase in the Mapuche proportion represented a 3.7% increased mortality risk by gallbladder cancer (95%CI 3.1–4.3%, P = 6×10−27). Individual-data results and extensive sensitivity analyses confirmed the association between Mapuche ancestry and gallbladder cancer. Increasing Mapuche proportions were also associated with an increased mortality due to asthma and, interestingly, with a decreased mortality by diabetes. The mortality due to skin, bladder, larynx, bronchus and lung cancers increased with increasing Aymara proportions. Described methods should be considered in future studies on human population genetics and human health. Complementary individual-based studies are needed to apportion the genetic and non-genetic components of associations identified relying on aggregate-data. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-05 |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/40051 Lorenzo Bermejo, Justo; Boekstegers, Felix; González Silos, Rosa; Marcelain, Katherine; Baez Benavides, Pablo; et al.; Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile; Public Library of Science; Plos Genetics; 13; 5; 5-2017; e1006756 1553-7390 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/40051 |
| identifier_str_mv |
Lorenzo Bermejo, Justo; Boekstegers, Felix; González Silos, Rosa; Marcelain, Katherine; Baez Benavides, Pablo; et al.; Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile; Public Library of Science; Plos Genetics; 13; 5; 5-2017; e1006756 1553-7390 CONICET Digital CONICET |
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eng |
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Public Library of Science |
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Public Library of Science |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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