Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

Autores: Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; Gárate Calderón, Valentina; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, Maria Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; Fischer, Christine; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Gonzalez-Jose, Rolando
Año de publicación: 2021
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current GBC prevention programs as well as C-reactive protein (CRP) level as a marker of chronic inflammation. APPROACH AND RESULTS: We applied two-sample Mendelian randomization (MR) using publicly available data and our own data from a retrospective Chilean and a prospective European study. Causality was assessed by inverse variance weighted (IVW), MR-Egger regression, and weighted median estimates complemented with sensitivity analyses on potential heterogeneity and pleiotropy, two-step MR, and mediation analysis. We found evidence for a causal effect of gallstone disease on GBC risk in Chileans (P = 9 × 10−5) and Europeans (P = 9 × 10−5). A genetically elevated body mass index (BMI) increased GBC risk in Chileans (P = 0.03), while higher CRP concentrations increased GBC risk in Europeans (P = 4.1 × 10−6). European results suggest causal effects of BMI on gallstone disease (P = 0.008); public Chilean data were not, however, available to enable assessment of the mediation effects among causal GBC risk factors. CONCLUSIONS: Two risk factors considered in the current Chilean program for GBC prevention are causally linked to GBC risk: gallstones and BMI. For Europeans, BMI showed a causal effect on gallstone risk, which was itself causally linked to GBC risk. (Hepatology 2021;73:1783-1796).
Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile
Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Brinster, Regina. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Marcelain, Katherine. Universidad de Chile; Chile
Fil: Gárate Calderón, Valentina. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile
Fil: Müller, Bettina. Instituto Nacional del Cáncer; Chile
Fil: de Toro, Gonzalo. Hospital Puerto Montt; Chile. Universidad Austral de Chile; Chile
Fil: Retamales, Javier. Instituto Nacional del Cáncer; Chile
Fil: Barajas, Olga. Universidad de Chile; Chile
Fil: Ahumada, Monica. Universidad de Chile; Chile
Fil: Morales, Erik. Hospital Regional de Talca; Chile. Universidad Católica del Maule; Chile
Fil: Rojas, Armando. Universidad Católica del Maule; Chile
Fil: Sanhueza, Verónica. Hospital Padre Hurtado; Chile
Fil: Loader, Denisse. Hospital Padre Hurtado; Chile
Fil: Rivera, María Teresa. Hospital del Salvador; Chile
Fil: Gutiérrez, Lorena. Hospital San Juan de Dios; Chile
Fil: Bernal, Giuliano. Universidad Católica del Norte; Chile
Fil: Ortega, Alejandro. Hospital Regional; Chile
Fil: Montalvo, Domingo. Hospital Regional Juan Noé Crevani; Chile
Fil: Portiño, Sergio. Universidad de Chile; Chile
Fil: Bertrán, Maria Enriqueta. Ministerio de Salud; Chile
Fil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Spencer, Loreto. Hospital Regional Guillermo Grant Benavente; Chile
Fil: Olloquequi, Jordi. Universidad Autónoma de Chile; Chile
Fil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Jenab, Mazda. International Agency For Research On Cancer; Alemania
Fil: Aleksandrova, Krasimira. German Institute Of Human Nutrition; Alemania
Fil: Katzke, Verena. German Cancer Research Center; Alemania
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Materia: POBLACIONES MESTIZAS
CANCER DE VESÍCULA
LATINOAMÉRICA
GENÓMICA
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/152388

Acceder

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network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype DataBarahona Ponce, CarolScherer, DominiqueBrinster, ReginaBoekstegers, FelixMarcelain, KatherineGárate Calderón, ValentinaMüller, Bettinade Toro, GonzaloRetamales, JavierBarajas, OlgaAhumada, MonicaMorales, ErikRojas, ArmandoSanhueza, VerónicaLoader, DenisseRivera, María TeresaGutiérrez, LorenaBernal, GiulianoOrtega, AlejandroMontalvo, DomingoPortiño, SergioBertrán, Maria EnriquetaGabler, FernandoSpencer, LoretoOlloquequi, JordiFischer, ChristineJenab, MazdaAleksandrova, KrasimiraKatzke, VerenaGonzalez-Jose, RolandoPOBLACIONES MESTIZASCANCER DE VESÍCULALATINOAMÉRICAGENÓMICAhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current GBC prevention programs as well as C-reactive protein (CRP) level as a marker of chronic inflammation. APPROACH AND RESULTS: We applied two-sample Mendelian randomization (MR) using publicly available data and our own data from a retrospective Chilean and a prospective European study. Causality was assessed by inverse variance weighted (IVW), MR-Egger regression, and weighted median estimates complemented with sensitivity analyses on potential heterogeneity and pleiotropy, two-step MR, and mediation analysis. We found evidence for a causal effect of gallstone disease on GBC risk in Chileans (P = 9 × 10−5) and Europeans (P = 9 × 10−5). A genetically elevated body mass index (BMI) increased GBC risk in Chileans (P = 0.03), while higher CRP concentrations increased GBC risk in Europeans (P = 4.1 × 10−6). European results suggest causal effects of BMI on gallstone disease (P = 0.008); public Chilean data were not, however, available to enable assessment of the mediation effects among causal GBC risk factors. CONCLUSIONS: Two risk factors considered in the current Chilean program for GBC prevention are causally linked to GBC risk: gallstones and BMI. For Europeans, BMI showed a causal effect on gallstone risk, which was itself causally linked to GBC risk. (Hepatology 2021;73:1783-1796).Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; ChileFil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Brinster, Regina. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Marcelain, Katherine. Universidad de Chile; ChileFil: Gárate Calderón, Valentina. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; ChileFil: Müller, Bettina. Instituto Nacional del Cáncer; ChileFil: de Toro, Gonzalo. Hospital Puerto Montt; Chile. Universidad Austral de Chile; ChileFil: Retamales, Javier. Instituto Nacional del Cáncer; ChileFil: Barajas, Olga. Universidad de Chile; ChileFil: Ahumada, Monica. Universidad de Chile; ChileFil: Morales, Erik. Hospital Regional de Talca; Chile. Universidad Católica del Maule; ChileFil: Rojas, Armando. Universidad Católica del Maule; ChileFil: Sanhueza, Verónica. Hospital Padre Hurtado; ChileFil: Loader, Denisse. Hospital Padre Hurtado; ChileFil: Rivera, María Teresa. Hospital del Salvador; ChileFil: Gutiérrez, Lorena. Hospital San Juan de Dios; ChileFil: Bernal, Giuliano. Universidad Católica del Norte; ChileFil: Ortega, Alejandro. Hospital Regional; ChileFil: Montalvo, Domingo. Hospital Regional Juan Noé Crevani; ChileFil: Portiño, Sergio. Universidad de Chile; ChileFil: Bertrán, Maria Enriqueta. Ministerio de Salud; ChileFil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; ChileFil: Spencer, Loreto. Hospital Regional Guillermo Grant Benavente; ChileFil: Olloquequi, Jordi. Universidad Autónoma de Chile; ChileFil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Jenab, Mazda. International Agency For Research On Cancer; AlemaniaFil: Aleksandrova, Krasimira. German Institute Of Human Nutrition; AlemaniaFil: Katzke, Verena. German Cancer Research Center; AlemaniaFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaJohn Wiley & Sons Inc.2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152388Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; et al.; Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 73; 5; 5-2021; 1783-17960270-91391527-3350CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31537info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.31537info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:00:29Zoai:ri.conicet.gov.ar:11336/152388instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:00:29.643CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
title	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
spellingShingle	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data Barahona Ponce, Carol POBLACIONES MESTIZAS CANCER DE VESÍCULA LATINOAMÉRICA GENÓMICA
title_short	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
title_full	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
title_fullStr	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
title_full_unstemmed	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
title_sort	Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data
dc.creator.none.fl_str_mv	Barahona Ponce, Carol Scherer, Dominique Brinster, Regina Boekstegers, Felix Marcelain, Katherine Gárate Calderón, Valentina Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi Fischer, Christine Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-Jose, Rolando
author	Barahona Ponce, Carol
author_facet	Barahona Ponce, Carol Scherer, Dominique Brinster, Regina Boekstegers, Felix Marcelain, Katherine Gárate Calderón, Valentina Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi Fischer, Christine Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-Jose, Rolando
author_role	author
author2	Scherer, Dominique Brinster, Regina Boekstegers, Felix Marcelain, Katherine Gárate Calderón, Valentina Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi Fischer, Christine Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-Jose, Rolando
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	POBLACIONES MESTIZAS CANCER DE VESÍCULA LATINOAMÉRICA GENÓMICA
topic	POBLACIONES MESTIZAS CANCER DE VESÍCULA LATINOAMÉRICA GENÓMICA
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current GBC prevention programs as well as C-reactive protein (CRP) level as a marker of chronic inflammation. APPROACH AND RESULTS: We applied two-sample Mendelian randomization (MR) using publicly available data and our own data from a retrospective Chilean and a prospective European study. Causality was assessed by inverse variance weighted (IVW), MR-Egger regression, and weighted median estimates complemented with sensitivity analyses on potential heterogeneity and pleiotropy, two-step MR, and mediation analysis. We found evidence for a causal effect of gallstone disease on GBC risk in Chileans (P = 9 × 10−5) and Europeans (P = 9 × 10−5). A genetically elevated body mass index (BMI) increased GBC risk in Chileans (P = 0.03), while higher CRP concentrations increased GBC risk in Europeans (P = 4.1 × 10−6). European results suggest causal effects of BMI on gallstone disease (P = 0.008); public Chilean data were not, however, available to enable assessment of the mediation effects among causal GBC risk factors. CONCLUSIONS: Two risk factors considered in the current Chilean program for GBC prevention are causally linked to GBC risk: gallstones and BMI. For Europeans, BMI showed a causal effect on gallstone risk, which was itself causally linked to GBC risk. (Hepatology 2021;73:1783-1796). Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Brinster, Regina. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Marcelain, Katherine. Universidad de Chile; Chile Fil: Gárate Calderón, Valentina. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile Fil: Müller, Bettina. Instituto Nacional del Cáncer; Chile Fil: de Toro, Gonzalo. Hospital Puerto Montt; Chile. Universidad Austral de Chile; Chile Fil: Retamales, Javier. Instituto Nacional del Cáncer; Chile Fil: Barajas, Olga. Universidad de Chile; Chile Fil: Ahumada, Monica. Universidad de Chile; Chile Fil: Morales, Erik. Hospital Regional de Talca; Chile. Universidad Católica del Maule; Chile Fil: Rojas, Armando. Universidad Católica del Maule; Chile Fil: Sanhueza, Verónica. Hospital Padre Hurtado; Chile Fil: Loader, Denisse. Hospital Padre Hurtado; Chile Fil: Rivera, María Teresa. Hospital del Salvador; Chile Fil: Gutiérrez, Lorena. Hospital San Juan de Dios; Chile Fil: Bernal, Giuliano. Universidad Católica del Norte; Chile Fil: Ortega, Alejandro. Hospital Regional; Chile Fil: Montalvo, Domingo. Hospital Regional Juan Noé Crevani; Chile Fil: Portiño, Sergio. Universidad de Chile; Chile Fil: Bertrán, Maria Enriqueta. Ministerio de Salud; Chile Fil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile Fil: Spencer, Loreto. Hospital Regional Guillermo Grant Benavente; Chile Fil: Olloquequi, Jordi. Universidad Autónoma de Chile; Chile Fil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Jenab, Mazda. International Agency For Research On Cancer; Alemania Fil: Aleksandrova, Krasimira. German Institute Of Human Nutrition; Alemania Fil: Katzke, Verena. German Cancer Research Center; Alemania Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
description	BACKGROUND AND AIMS: Gallbladder cancer (GBC) is a neglected disease with substantial geographical variability: Chile shows the highest incidence worldwide, while GBC is relatively rare in Europe. Here, we investigate the causal effects of risk factors considered in current GBC prevention programs as well as C-reactive protein (CRP) level as a marker of chronic inflammation. APPROACH AND RESULTS: We applied two-sample Mendelian randomization (MR) using publicly available data and our own data from a retrospective Chilean and a prospective European study. Causality was assessed by inverse variance weighted (IVW), MR-Egger regression, and weighted median estimates complemented with sensitivity analyses on potential heterogeneity and pleiotropy, two-step MR, and mediation analysis. We found evidence for a causal effect of gallstone disease on GBC risk in Chileans (P = 9 × 10−5) and Europeans (P = 9 × 10−5). A genetically elevated body mass index (BMI) increased GBC risk in Chileans (P = 0.03), while higher CRP concentrations increased GBC risk in Europeans (P = 4.1 × 10−6). European results suggest causal effects of BMI on gallstone disease (P = 0.008); public Chilean data were not, however, available to enable assessment of the mediation effects among causal GBC risk factors. CONCLUSIONS: Two risk factors considered in the current Chilean program for GBC prevention are causally linked to GBC risk: gallstones and BMI. For Europeans, BMI showed a causal effect on gallstone risk, which was itself causally linked to GBC risk. (Hepatology 2021;73:1783-1796).
publishDate	2021
dc.date.none.fl_str_mv	2021-05
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/152388 Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; et al.; Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 73; 5; 5-2021; 1783-1796 0270-9139 1527-3350 CONICET Digital CONICET
url	http://hdl.handle.net/11336/152388
identifier_str_mv	Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; et al.; Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data; John Wiley & Sons Inc.; Hepatology (Baltimore, Md.); 73; 5; 5-2021; 1783-1796 0270-9139 1527-3350 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.31537 info:eu-repo/semantics/altIdentifier/doi/10.1002/hep.31537
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	John Wiley & Sons Inc.
publisher.none.fl_str_mv	John Wiley & Sons Inc.
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
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instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data

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