Balanced levels of nerve growth factor are required for normal pregnancy progression
- Autores
- Frank, Pierre; Barrientos, Gabriela Laura; Tirado González, Irene; Cohen, Marie; Moschansky, Petra; Peters, Eva M.; Klapp, Burghard F.; Rose, Matthias; Tometten, Mareike; Blois, Sandra M.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Nerve growth factor (NGF), the first identified member of the family of neurotrophins, is thought to play a critical role in the initiation of the decidual response in stress-challenged pregnant mice. However, the contribution of this pathway to physiological events during the establishment and maintenance of pregnancy remains largely elusive. Using NGF depletion and supplementation strategies alternatively, in this study, we demonstrated that a successful pregnancy is sensitive to disturbances in NGF levels in mice. Treatment with NGF further boosted fetal loss rates in the high-abortion rate CBA/J x DBA/2J mouse model by amplifying a local inflammatory response through recruitment of NGF-expressing immune cells, increased decidual innervation with substance P+ nerve fibres and a Th1 cytokine shift. Similarly, treatment with a NGF-neutralising antibody in BALB/c-mated CBA/J mice, a normal-pregnancy model, also induced abortions associated with increased infiltration of tropomyosin kinase receptor A-expressing NK cells to the decidua. Importantly, in neither of the models, pregnancy loss was associated with defective ovarian function, angiogenesis or placental development. We further demonstrated that spontaneous abortion in humans is associated with up-regulated synthesis and an aberrant distribution of NGF in placental tissue. Thus, a local threshold of NGF expression seems to be necessary to ensure maternal tolerance in healthy pregnancies, but when surpassed may result in fetal rejection due to exacerbated inflammation.
Fil: Frank, Pierre. Medicine University of Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Tirado González, Irene. Medicine University of Berlin; Alemania
Fil: Cohen, Marie. Universidad de Ginebra; Suiza
Fil: Moschansky, Petra. Medicine University of Berlin; Alemania
Fil: Peters, Eva M.. Medicine University of Berlin; Alemania. University Giessen; Alemania
Fil: Klapp, Burghard F.. Medicine University of Berlin; Alemania
Fil: Rose, Matthias. Medicine University of Berlin; Alemania
Fil: Tometten, Mareike. Universitat Duisburg - Essen; Alemania
Fil: Blois, Sandra M.. Medicine University of Berlin; Alemania - Materia
-
Nerve growth factor
Pregnancy
Spontaneous abortion - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/35958
Ver los metadatos del registro completo
id |
CONICETDig_ceb547dad5b7544ec6363aeb5744ce21 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/35958 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Balanced levels of nerve growth factor are required for normal pregnancy progressionFrank, PierreBarrientos, Gabriela LauraTirado González, IreneCohen, MarieMoschansky, PetraPeters, Eva M.Klapp, Burghard F.Rose, MatthiasTometten, MareikeBlois, Sandra M.Nerve growth factorPregnancySpontaneous abortionhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Nerve growth factor (NGF), the first identified member of the family of neurotrophins, is thought to play a critical role in the initiation of the decidual response in stress-challenged pregnant mice. However, the contribution of this pathway to physiological events during the establishment and maintenance of pregnancy remains largely elusive. Using NGF depletion and supplementation strategies alternatively, in this study, we demonstrated that a successful pregnancy is sensitive to disturbances in NGF levels in mice. Treatment with NGF further boosted fetal loss rates in the high-abortion rate CBA/J x DBA/2J mouse model by amplifying a local inflammatory response through recruitment of NGF-expressing immune cells, increased decidual innervation with substance P+ nerve fibres and a Th1 cytokine shift. Similarly, treatment with a NGF-neutralising antibody in BALB/c-mated CBA/J mice, a normal-pregnancy model, also induced abortions associated with increased infiltration of tropomyosin kinase receptor A-expressing NK cells to the decidua. Importantly, in neither of the models, pregnancy loss was associated with defective ovarian function, angiogenesis or placental development. We further demonstrated that spontaneous abortion in humans is associated with up-regulated synthesis and an aberrant distribution of NGF in placental tissue. Thus, a local threshold of NGF expression seems to be necessary to ensure maternal tolerance in healthy pregnancies, but when surpassed may result in fetal rejection due to exacerbated inflammation.Fil: Frank, Pierre. Medicine University of Berlin; AlemaniaFil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tirado González, Irene. Medicine University of Berlin; AlemaniaFil: Cohen, Marie. Universidad de Ginebra; SuizaFil: Moschansky, Petra. Medicine University of Berlin; AlemaniaFil: Peters, Eva M.. Medicine University of Berlin; Alemania. University Giessen; AlemaniaFil: Klapp, Burghard F.. Medicine University of Berlin; AlemaniaFil: Rose, Matthias. Medicine University of Berlin; AlemaniaFil: Tometten, Mareike. Universitat Duisburg - Essen; AlemaniaFil: Blois, Sandra M.. Medicine University of Berlin; AlemaniaBioScientifica2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/35958Frank, Pierre; Barrientos, Gabriela Laura; Tirado González, Irene; Cohen, Marie; Moschansky, Petra; et al.; Balanced levels of nerve growth factor are required for normal pregnancy progression; BioScientifica; Reproduction; 148; 2; 8-2014; 179-1891470-16261741-7899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1530/REP-14-0112info:eu-repo/semantics/altIdentifier/url/http://www.reproduction-online.org/content/148/2/179info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:31Zoai:ri.conicet.gov.ar:11336/35958instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:31.479CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
title |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
spellingShingle |
Balanced levels of nerve growth factor are required for normal pregnancy progression Frank, Pierre Nerve growth factor Pregnancy Spontaneous abortion |
title_short |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
title_full |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
title_fullStr |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
title_full_unstemmed |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
title_sort |
Balanced levels of nerve growth factor are required for normal pregnancy progression |
dc.creator.none.fl_str_mv |
Frank, Pierre Barrientos, Gabriela Laura Tirado González, Irene Cohen, Marie Moschansky, Petra Peters, Eva M. Klapp, Burghard F. Rose, Matthias Tometten, Mareike Blois, Sandra M. |
author |
Frank, Pierre |
author_facet |
Frank, Pierre Barrientos, Gabriela Laura Tirado González, Irene Cohen, Marie Moschansky, Petra Peters, Eva M. Klapp, Burghard F. Rose, Matthias Tometten, Mareike Blois, Sandra M. |
author_role |
author |
author2 |
Barrientos, Gabriela Laura Tirado González, Irene Cohen, Marie Moschansky, Petra Peters, Eva M. Klapp, Burghard F. Rose, Matthias Tometten, Mareike Blois, Sandra M. |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Nerve growth factor Pregnancy Spontaneous abortion |
topic |
Nerve growth factor Pregnancy Spontaneous abortion |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Nerve growth factor (NGF), the first identified member of the family of neurotrophins, is thought to play a critical role in the initiation of the decidual response in stress-challenged pregnant mice. However, the contribution of this pathway to physiological events during the establishment and maintenance of pregnancy remains largely elusive. Using NGF depletion and supplementation strategies alternatively, in this study, we demonstrated that a successful pregnancy is sensitive to disturbances in NGF levels in mice. Treatment with NGF further boosted fetal loss rates in the high-abortion rate CBA/J x DBA/2J mouse model by amplifying a local inflammatory response through recruitment of NGF-expressing immune cells, increased decidual innervation with substance P+ nerve fibres and a Th1 cytokine shift. Similarly, treatment with a NGF-neutralising antibody in BALB/c-mated CBA/J mice, a normal-pregnancy model, also induced abortions associated with increased infiltration of tropomyosin kinase receptor A-expressing NK cells to the decidua. Importantly, in neither of the models, pregnancy loss was associated with defective ovarian function, angiogenesis or placental development. We further demonstrated that spontaneous abortion in humans is associated with up-regulated synthesis and an aberrant distribution of NGF in placental tissue. Thus, a local threshold of NGF expression seems to be necessary to ensure maternal tolerance in healthy pregnancies, but when surpassed may result in fetal rejection due to exacerbated inflammation. Fil: Frank, Pierre. Medicine University of Berlin; Alemania Fil: Barrientos, Gabriela Laura. Medicine University of Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Tirado González, Irene. Medicine University of Berlin; Alemania Fil: Cohen, Marie. Universidad de Ginebra; Suiza Fil: Moschansky, Petra. Medicine University of Berlin; Alemania Fil: Peters, Eva M.. Medicine University of Berlin; Alemania. University Giessen; Alemania Fil: Klapp, Burghard F.. Medicine University of Berlin; Alemania Fil: Rose, Matthias. Medicine University of Berlin; Alemania Fil: Tometten, Mareike. Universitat Duisburg - Essen; Alemania Fil: Blois, Sandra M.. Medicine University of Berlin; Alemania |
description |
Nerve growth factor (NGF), the first identified member of the family of neurotrophins, is thought to play a critical role in the initiation of the decidual response in stress-challenged pregnant mice. However, the contribution of this pathway to physiological events during the establishment and maintenance of pregnancy remains largely elusive. Using NGF depletion and supplementation strategies alternatively, in this study, we demonstrated that a successful pregnancy is sensitive to disturbances in NGF levels in mice. Treatment with NGF further boosted fetal loss rates in the high-abortion rate CBA/J x DBA/2J mouse model by amplifying a local inflammatory response through recruitment of NGF-expressing immune cells, increased decidual innervation with substance P+ nerve fibres and a Th1 cytokine shift. Similarly, treatment with a NGF-neutralising antibody in BALB/c-mated CBA/J mice, a normal-pregnancy model, also induced abortions associated with increased infiltration of tropomyosin kinase receptor A-expressing NK cells to the decidua. Importantly, in neither of the models, pregnancy loss was associated with defective ovarian function, angiogenesis or placental development. We further demonstrated that spontaneous abortion in humans is associated with up-regulated synthesis and an aberrant distribution of NGF in placental tissue. Thus, a local threshold of NGF expression seems to be necessary to ensure maternal tolerance in healthy pregnancies, but when surpassed may result in fetal rejection due to exacerbated inflammation. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/35958 Frank, Pierre; Barrientos, Gabriela Laura; Tirado González, Irene; Cohen, Marie; Moschansky, Petra; et al.; Balanced levels of nerve growth factor are required for normal pregnancy progression; BioScientifica; Reproduction; 148; 2; 8-2014; 179-189 1470-1626 1741-7899 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/35958 |
identifier_str_mv |
Frank, Pierre; Barrientos, Gabriela Laura; Tirado González, Irene; Cohen, Marie; Moschansky, Petra; et al.; Balanced levels of nerve growth factor are required for normal pregnancy progression; BioScientifica; Reproduction; 148; 2; 8-2014; 179-189 1470-1626 1741-7899 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1530/REP-14-0112 info:eu-repo/semantics/altIdentifier/url/http://www.reproduction-online.org/content/148/2/179 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioScientifica |
publisher.none.fl_str_mv |
BioScientifica |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269804771147776 |
score |
13.13397 |