Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy

Autores
Ramhorst, Rosanna Elizabeth; Gutierrez, Gabriela Lidia; Corigliano, Adriana; Junovich, Gisela Yael; Fainboim, Leonardo
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem: Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES regulation during early pregnancy and potential failures leading to losses of pregnancies. Method of study: RANTES and progesterone levels were determined in sera and feto-placental units from high resorption rate CBA/J × DBA/2 pregnant females and compared with CBA/J × BALB/c normal pregnant mice. RANTES in vitro modulation was also studied in nulliparous, primiparous and multiparous CBA/J and BALB/c cells in response to paternal alloantigen and progesterone stimulation. Results: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas pregnancies with male BALB/c or DBA/2 increased its production. However, feto-placental units from CBA/J females are high producers of progesterone and RANTES. Conclusion: These data suggest that the beneficial effect of RANTES on feto-maternal interface requires an optimal concentration range and might be modulated by progesterone, hence exacerbated placental expression could be associated with high resorption rate.
Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Corigliano, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
ABORTION
PREGNANCY
PROGESTERONE
RANTES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94245
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/94245
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancyRamhorst, Rosanna ElizabethGutierrez, Gabriela LidiaCorigliano, AdrianaJunovich, Gisela YaelFainboim, LeonardoABORTIONPREGNANCYPROGESTERONERANTEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Problem: Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES regulation during early pregnancy and potential failures leading to losses of pregnancies. Method of study: RANTES and progesterone levels were determined in sera and feto-placental units from high resorption rate CBA/J × DBA/2 pregnant females and compared with CBA/J × BALB/c normal pregnant mice. RANTES in vitro modulation was also studied in nulliparous, primiparous and multiparous CBA/J and BALB/c cells in response to paternal alloantigen and progesterone stimulation. Results: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas pregnancies with male BALB/c or DBA/2 increased its production. However, feto-placental units from CBA/J females are high producers of progesterone and RANTES. Conclusion: These data suggest that the beneficial effect of RANTES on feto-maternal interface requires an optimal concentration range and might be modulated by progesterone, hence exacerbated placental expression could be associated with high resorption rate.Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Corigliano, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaWiley Blackwell Publishing, Inc2007-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94245Ramhorst, Rosanna Elizabeth; Gutierrez, Gabriela Lidia; Corigliano, Adriana; Junovich, Gisela Yael; Fainboim, Leonardo; Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 57; 2; 2-2007; 147-1521046-7408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0897.2006.00458.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2006.00458.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:25Zoai:ri.conicet.gov.ar:11336/94245instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:25.853CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
title Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
spellingShingle Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
Ramhorst, Rosanna Elizabeth
ABORTION
PREGNANCY
PROGESTERONE
RANTES
title_short Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
title_full Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
title_fullStr Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
title_full_unstemmed Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
title_sort Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy
dc.creator.none.fl_str_mv Ramhorst, Rosanna Elizabeth
Gutierrez, Gabriela Lidia
Corigliano, Adriana
Junovich, Gisela Yael
Fainboim, Leonardo
author Ramhorst, Rosanna Elizabeth
author_facet Ramhorst, Rosanna Elizabeth
Gutierrez, Gabriela Lidia
Corigliano, Adriana
Junovich, Gisela Yael
Fainboim, Leonardo
author_role author
author2 Gutierrez, Gabriela Lidia
Corigliano, Adriana
Junovich, Gisela Yael
Fainboim, Leonardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv ABORTION
PREGNANCY
PROGESTERONE
RANTES
topic ABORTION
PREGNANCY
PROGESTERONE
RANTES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Problem: Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES regulation during early pregnancy and potential failures leading to losses of pregnancies. Method of study: RANTES and progesterone levels were determined in sera and feto-placental units from high resorption rate CBA/J × DBA/2 pregnant females and compared with CBA/J × BALB/c normal pregnant mice. RANTES in vitro modulation was also studied in nulliparous, primiparous and multiparous CBA/J and BALB/c cells in response to paternal alloantigen and progesterone stimulation. Results: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas pregnancies with male BALB/c or DBA/2 increased its production. However, feto-placental units from CBA/J females are high producers of progesterone and RANTES. Conclusion: These data suggest that the beneficial effect of RANTES on feto-maternal interface requires an optimal concentration range and might be modulated by progesterone, hence exacerbated placental expression could be associated with high resorption rate.
Fil: Ramhorst, Rosanna Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Gutierrez, Gabriela Lidia. Centro de Investigación de la Fundación Repro; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Corigliano, Adriana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Junovich, Gisela Yael. Halitus Instituto Medico; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Fainboim, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Problem: Several studies indicate that RANTES (regulated on activation, normal T cell expressed and secreted) is able to downregulate T-cell responses which suggest it might be relevant for fetal tolerance induction. However, the role of RANTES in pregnancy had not been established. Here we investigate RANTES regulation during early pregnancy and potential failures leading to losses of pregnancies. Method of study: RANTES and progesterone levels were determined in sera and feto-placental units from high resorption rate CBA/J × DBA/2 pregnant females and compared with CBA/J × BALB/c normal pregnant mice. RANTES in vitro modulation was also studied in nulliparous, primiparous and multiparous CBA/J and BALB/c cells in response to paternal alloantigen and progesterone stimulation. Results: Nulliparous CBA/J females were quantitatively deficient in RANTES sera levels, whereas pregnancies with male BALB/c or DBA/2 increased its production. However, feto-placental units from CBA/J females are high producers of progesterone and RANTES. Conclusion: These data suggest that the beneficial effect of RANTES on feto-maternal interface requires an optimal concentration range and might be modulated by progesterone, hence exacerbated placental expression could be associated with high resorption rate.
publishDate 2007
dc.date.none.fl_str_mv 2007-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94245
Ramhorst, Rosanna Elizabeth; Gutierrez, Gabriela Lidia; Corigliano, Adriana; Junovich, Gisela Yael; Fainboim, Leonardo; Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 57; 2; 2-2007; 147-152
1046-7408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94245
identifier_str_mv Ramhorst, Rosanna Elizabeth; Gutierrez, Gabriela Lidia; Corigliano, Adriana; Junovich, Gisela Yael; Fainboim, Leonardo; Implication of RANTES in the modulation of alloimmune response by progesterone during pregnancy; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 57; 2; 2-2007; 147-152
1046-7408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0897.2006.00458.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2006.00458.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269958316228608
score 13.13397

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