Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines

Autores
Di Girolamo, Fabio Augusto; Sabatini, Diego Jorge; Fasan, Raúl A.; Echegoyen, Maia; Vela, Mauro; Pereira, Claudio Alejandro; Maure, Pablo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work two cytokines were used in combination with inactivated bacteria (bacterin) to test the bovine conjuctival immune response to the pathogen Moraxella bovis, the causative agent of Infectious bovine keratoconjunctivitis (IBK). Treatments using the bacterin vaccine combined with interleukin-2 and interferon-α as adjuvants (Group A), the bacterin vaccine only (Group B), and controls without treatment (Group C), were applied by ocular spraying to evaluate the local immune response in the corneal structure of cattle experimentally infected with M. bovis. Six weeks after infection, 14 out of a total of 34 animals presented different corneal lesions; 9 corresponding to the control group C, 4 to the group B and only one to the group A. According to the clinical manifestations, a numeric score was calculated. Control animals presented the highest score value (12 points), followed by group B (7.5 points) and group A (1 point). These results suggest that the addition of cytokines to M. bovis treatments can reduce not only eye injuries caused by IBK but also the number of diseased animals. © 2012 Elsevier B.V.
Fil: Di Girolamo, Fabio Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Centro de Inmunoterapia Veterinaria; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Sabatini, Diego Jorge. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Fasan, Raúl A.. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Echegoyen, Maia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Vela, Mauro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Maure, Pablo. Centro de Inmunoterapia Veterinaria; Argentina
Materia
Cytokines
Infectious Bovine Keratoconjunctivitis
Moraxella Bovis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67433
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67433
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccinesDi Girolamo, Fabio AugustoSabatini, Diego JorgeFasan, Raúl A.Echegoyen, MaiaVela, MauroPereira, Claudio AlejandroMaure, PabloCytokinesInfectious Bovine KeratoconjunctivitisMoraxella Bovishttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4In this work two cytokines were used in combination with inactivated bacteria (bacterin) to test the bovine conjuctival immune response to the pathogen Moraxella bovis, the causative agent of Infectious bovine keratoconjunctivitis (IBK). Treatments using the bacterin vaccine combined with interleukin-2 and interferon-α as adjuvants (Group A), the bacterin vaccine only (Group B), and controls without treatment (Group C), were applied by ocular spraying to evaluate the local immune response in the corneal structure of cattle experimentally infected with M. bovis. Six weeks after infection, 14 out of a total of 34 animals presented different corneal lesions; 9 corresponding to the control group C, 4 to the group B and only one to the group A. According to the clinical manifestations, a numeric score was calculated. Control animals presented the highest score value (12 points), followed by group B (7.5 points) and group A (1 point). These results suggest that the addition of cytokines to M. bovis treatments can reduce not only eye injuries caused by IBK but also the number of diseased animals. © 2012 Elsevier B.V.Fil: Di Girolamo, Fabio Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Centro de Inmunoterapia Veterinaria; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Sabatini, Diego Jorge. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Fasan, Raúl A.. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Echegoyen, Maia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Vela, Mauro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; ArgentinaFil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Maure, Pablo. Centro de Inmunoterapia Veterinaria; ArgentinaElsevier Science2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67433Di Girolamo, Fabio Augusto; Sabatini, Diego Jorge; Fasan, Raúl A.; Echegoyen, Maia; Vela, Mauro; et al.; Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 563-5660165-2427CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.12.022info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242712000025info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:20Zoai:ri.conicet.gov.ar:11336/67433instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:21.032CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
title Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
spellingShingle Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
Di Girolamo, Fabio Augusto
Cytokines
Infectious Bovine Keratoconjunctivitis
Moraxella Bovis
title_short Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
title_full Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
title_fullStr Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
title_full_unstemmed Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
title_sort Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines
dc.creator.none.fl_str_mv Di Girolamo, Fabio Augusto
Sabatini, Diego Jorge
Fasan, Raúl A.
Echegoyen, Maia
Vela, Mauro
Pereira, Claudio Alejandro
Maure, Pablo
author Di Girolamo, Fabio Augusto
author_facet Di Girolamo, Fabio Augusto
Sabatini, Diego Jorge
Fasan, Raúl A.
Echegoyen, Maia
Vela, Mauro
Pereira, Claudio Alejandro
Maure, Pablo
author_role author
author2 Sabatini, Diego Jorge
Fasan, Raúl A.
Echegoyen, Maia
Vela, Mauro
Pereira, Claudio Alejandro
Maure, Pablo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Infectious Bovine Keratoconjunctivitis
Moraxella Bovis
topic Cytokines
Infectious Bovine Keratoconjunctivitis
Moraxella Bovis
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv In this work two cytokines were used in combination with inactivated bacteria (bacterin) to test the bovine conjuctival immune response to the pathogen Moraxella bovis, the causative agent of Infectious bovine keratoconjunctivitis (IBK). Treatments using the bacterin vaccine combined with interleukin-2 and interferon-α as adjuvants (Group A), the bacterin vaccine only (Group B), and controls without treatment (Group C), were applied by ocular spraying to evaluate the local immune response in the corneal structure of cattle experimentally infected with M. bovis. Six weeks after infection, 14 out of a total of 34 animals presented different corneal lesions; 9 corresponding to the control group C, 4 to the group B and only one to the group A. According to the clinical manifestations, a numeric score was calculated. Control animals presented the highest score value (12 points), followed by group B (7.5 points) and group A (1 point). These results suggest that the addition of cytokines to M. bovis treatments can reduce not only eye injuries caused by IBK but also the number of diseased animals. © 2012 Elsevier B.V.
Fil: Di Girolamo, Fabio Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Centro de Inmunoterapia Veterinaria; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Sabatini, Diego Jorge. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Fasan, Raúl A.. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Echegoyen, Maia. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Vela, Mauro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Agrarias; Argentina
Fil: Pereira, Claudio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Maure, Pablo. Centro de Inmunoterapia Veterinaria; Argentina
description In this work two cytokines were used in combination with inactivated bacteria (bacterin) to test the bovine conjuctival immune response to the pathogen Moraxella bovis, the causative agent of Infectious bovine keratoconjunctivitis (IBK). Treatments using the bacterin vaccine combined with interleukin-2 and interferon-α as adjuvants (Group A), the bacterin vaccine only (Group B), and controls without treatment (Group C), were applied by ocular spraying to evaluate the local immune response in the corneal structure of cattle experimentally infected with M. bovis. Six weeks after infection, 14 out of a total of 34 animals presented different corneal lesions; 9 corresponding to the control group C, 4 to the group B and only one to the group A. According to the clinical manifestations, a numeric score was calculated. Control animals presented the highest score value (12 points), followed by group B (7.5 points) and group A (1 point). These results suggest that the addition of cytokines to M. bovis treatments can reduce not only eye injuries caused by IBK but also the number of diseased animals. © 2012 Elsevier B.V.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67433
Di Girolamo, Fabio Augusto; Sabatini, Diego Jorge; Fasan, Raúl A.; Echegoyen, Maia; Vela, Mauro; et al.; Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 563-566
0165-2427
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67433
identifier_str_mv Di Girolamo, Fabio Augusto; Sabatini, Diego Jorge; Fasan, Raúl A.; Echegoyen, Maia; Vela, Mauro; et al.; Evaluation of cytokines as adjuvants of infectious bovine keratoconjunctivitis vaccines; Elsevier Science; Veterinary Immunology And Immunopathology; 145; 1-2; 1-2012; 563-566
0165-2427
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vetimm.2011.12.022
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0165242712000025
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269999854518272
score 13.13397

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