A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants

Autores
Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (n = 10) and UNCD-coated (n = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, p > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.
Fil: Auciello, Orlando. University of Texas; Estados Unidos
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina
Fil: Kang, Karam. University of Texas; Estados Unidos
Fil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ULTRANANOCRYSTALLINE DIAMOND COATING
SURFACE TREATMENT
BIOTRIBOCORROSION
BIOCOMPATIBILITY
TITANIUM MICRO-IMPLANTS
OSSEOINTEGRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216279
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/216279
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental ImplantsAuciello, OrlandoRenou, Sandra JudithKang, KaramTasat, Deborah RuthOlmedo, Daniel GustavoULTRANANOCRYSTALLINE DIAMOND COATINGSURFACE TREATMENTBIOTRIBOCORROSIONBIOCOMPATIBILITYTITANIUM MICRO-IMPLANTSOSSEOINTEGRATIONhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.Fil: Auciello, Orlando. University of Texas; Estados UnidosFil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; ArgentinaFil: Kang, Karam. University of Texas; Estados UnidosFil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; ArgentinaFil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaMDPI2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216279Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-152079-49912079-4991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/782info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050782info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:38:06Zoai:ri.conicet.gov.ar:11336/216279instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:38:06.511CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
title A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
spellingShingle A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
Auciello, Orlando
ULTRANANOCRYSTALLINE DIAMOND COATING
SURFACE TREATMENT
BIOTRIBOCORROSION
BIOCOMPATIBILITY
TITANIUM MICRO-IMPLANTS
OSSEOINTEGRATION
title_short A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
title_full A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
title_fullStr A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
title_full_unstemmed A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
title_sort A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
dc.creator.none.fl_str_mv Auciello, Orlando
Renou, Sandra Judith
Kang, Karam
Tasat, Deborah Ruth
Olmedo, Daniel Gustavo
author Auciello, Orlando
author_facet Auciello, Orlando
Renou, Sandra Judith
Kang, Karam
Tasat, Deborah Ruth
Olmedo, Daniel Gustavo
author_role author
author2 Renou, Sandra Judith
Kang, Karam
Tasat, Deborah Ruth
Olmedo, Daniel Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv ULTRANANOCRYSTALLINE DIAMOND COATING
SURFACE TREATMENT
BIOTRIBOCORROSION
BIOCOMPATIBILITY
TITANIUM MICRO-IMPLANTS
OSSEOINTEGRATION
topic ULTRANANOCRYSTALLINE DIAMOND COATING
SURFACE TREATMENT
BIOTRIBOCORROSION
BIOCOMPATIBILITY
TITANIUM MICRO-IMPLANTS
OSSEOINTEGRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.
Fil: Auciello, Orlando. University of Texas; Estados Unidos
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina
Fil: Kang, Karam. University of Texas; Estados Unidos
Fil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.
publishDate 2022
dc.date.none.fl_str_mv 2022-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216279
Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-15
2079-4991
2079-4991
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216279
identifier_str_mv Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-15
2079-4991
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/782
info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050782
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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