A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants
- Autores
- Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (n = 10) and UNCD-coated (n = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, p > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.
Fil: Auciello, Orlando. University of Texas; Estados Unidos
Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina
Fil: Kang, Karam. University of Texas; Estados Unidos
Fil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina - Materia
-
ULTRANANOCRYSTALLINE DIAMOND COATING
SURFACE TREATMENT
BIOTRIBOCORROSION
BIOCOMPATIBILITY
TITANIUM MICRO-IMPLANTS
OSSEOINTEGRATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/216279
Ver los metadatos del registro completo
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A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental ImplantsAuciello, OrlandoRenou, Sandra JudithKang, KaramTasat, Deborah RuthOlmedo, Daniel GustavoULTRANANOCRYSTALLINE DIAMOND COATINGSURFACE TREATMENTBIOTRIBOCORROSIONBIOCOMPATIBILITYTITANIUM MICRO-IMPLANTSOSSEOINTEGRATIONhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants.Fil: Auciello, Orlando. University of Texas; Estados UnidosFil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; ArgentinaFil: Kang, Karam. University of Texas; Estados UnidosFil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; ArgentinaFil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaMDPI2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216279Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-152079-49912079-4991CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/782info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050782info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:20Zoai:ri.conicet.gov.ar:11336/216279instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:20.369CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
title |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
spellingShingle |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants Auciello, Orlando ULTRANANOCRYSTALLINE DIAMOND COATING SURFACE TREATMENT BIOTRIBOCORROSION BIOCOMPATIBILITY TITANIUM MICRO-IMPLANTS OSSEOINTEGRATION |
title_short |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
title_full |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
title_fullStr |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
title_full_unstemmed |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
title_sort |
A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants |
dc.creator.none.fl_str_mv |
Auciello, Orlando Renou, Sandra Judith Kang, Karam Tasat, Deborah Ruth Olmedo, Daniel Gustavo |
author |
Auciello, Orlando |
author_facet |
Auciello, Orlando Renou, Sandra Judith Kang, Karam Tasat, Deborah Ruth Olmedo, Daniel Gustavo |
author_role |
author |
author2 |
Renou, Sandra Judith Kang, Karam Tasat, Deborah Ruth Olmedo, Daniel Gustavo |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
ULTRANANOCRYSTALLINE DIAMOND COATING SURFACE TREATMENT BIOTRIBOCORROSION BIOCOMPATIBILITY TITANIUM MICRO-IMPLANTS OSSEOINTEGRATION |
topic |
ULTRANANOCRYSTALLINE DIAMOND COATING SURFACE TREATMENT BIOTRIBOCORROSION BIOCOMPATIBILITY TITANIUM MICRO-IMPLANTS OSSEOINTEGRATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants. Fil: Auciello, Orlando. University of Texas; Estados Unidos Fil: Renou, Sandra Judith. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina Fil: Kang, Karam. University of Texas; Estados Unidos Fil: Tasat, Deborah Ruth. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Tecnologias Emergentes y Ciencias Aplicadas. - Universidad Nacional de San Martin. Instituto de Tecnologias Emergentes y Ciencias Aplicadas.; Argentina Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina |
description |
Implant therapy using osseointegratable titanium (Ti) dental implants has revolutionized clinical dental practice and has shown a high rate of success. However, because a metallic implant is in contact with body tissues and fluids in vivo, ions/particles can be released into the biological milieu as a result of corrosion or biotribocorrosion. Ultrananocrystalline diamond (UNCD) coatings possess a synergistic combination of mechanical, tribological, and chemical properties, which makes UNCD highly biocompatible. In addition, because the UNCD coating is made of carbon (C), a component of human DNA, cells, and molecules, it is potentially a highly biocompatible coating for medical implant devices. The aim of the present research was to evaluate tissue response to UNCD-coated titanium micro-implants using a murine model designed to evaluate biocompatibility. Non-coated (<em>n</em> = 10) and UNCD-coated (<em>n</em> = 10) orthodontic Ti micro-implants were placed in the hematopoietic bone marrow of the tibia of male Wistar rats. The animals were euthanized 30 days post implantation. The tibiae were resected, and ground histologic sections were obtained and stained with toluidine blue. Histologically, both groups showed lamellar bone tissue in contact with the implants (osseointegration). No inflammatory or multinucleated giant cells were observed. Histomorphometric evaluation showed no statistically significant differences in the percentage of BIC between groups (C: 53.40 ± 13% vs. UNCD: 58.82 ± 9%, <em>p</em> > 0.05). UNCD showed good biocompatibility properties. Although the percentage of BIC (osseointegration) was similar in UNCD-coated and control Ti micro-implants, the documented tribological properties of UNCD make it a superior implant coating material. Given the current surge in the use of nano-coatings, nanofilms, and nanostructured surfaces to enhance the biocompatibility of biomedical implants, the results of the present study contribute valuable data for the manufacture of UNCD coatings as a new generation of superior dental implants. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/216279 Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-15 2079-4991 2079-4991 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/216279 |
identifier_str_mv |
Auciello, Orlando; Renou, Sandra Judith; Kang, Karam; Tasat, Deborah Ruth; Olmedo, Daniel Gustavo; A Biocompatible Ultrananocrystalline Diamond (UNCD) Coating for a New Generation of Dental Implants; MDPI; Nanomaterials; 12; 5; 2-2022; 1-15 2079-4991 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-4991/12/5/782 info:eu-repo/semantics/altIdentifier/doi/10.3390/nano12050782 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614430651842560 |
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13.070432 |