Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes

Autores
Giglio, Maximo Juan Evaristo; Giannunzio, Graciela Ana; Olmedo, Daniel Gustavo; Guglielmotti, Maria Beatriz
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to evaluate the effects of experimental diabetes on the healing period leading to osseointegration. Wistar rats were injected with a single dose of streptozotocin (STZ); body weight and food intake were assessed every 48 hours. On days 2, 12, 26, and 42 post-STZ, glucemia, plasma hemoglobin, and urea were determined. Twelve days post-STZ, a titanium laminar implant was placed in the right tibia of each rat. Two groups of 20 rats each were killed on days 14 and 30 postimplantation, respectively. Results (ANOVA test) showed STZ-treated rats to have 1) a significant decrease in body weight; 2) an increase in food intake; 3) normal hemoglobin and plasma urea values; 4) a significant increase in glucemia; and 5) a decrease in tibiae length. Microscopic evaluation 14 days postimplantation revealed the presence of woven bone, and, at 30 days, laminar bone was in contact with the implant. Our findings show that, in this model of periimplant bone repair and under the experimental conditions stated herein, STZ-induced diabetes retards periimplant bone healing.
Fil: Giglio, Maximo Juan Evaristo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Patología y Clinica Bucodental I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Giannunzio, Graciela Ana. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Bone Healing
Implants
Diabetes
Osseointegration
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44793
Acceder
id CONICETDig_7dfa4d15cdd5d05c862f6379abe4faca
oai_identifier_str oai:ri.conicet.gov.ar:11336/44793
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental DiabetesGiglio, Maximo Juan EvaristoGiannunzio, Graciela AnaOlmedo, Daniel GustavoGuglielmotti, Maria BeatrizBone HealingImplantsDiabetesOsseointegrationhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The aim of this study was to evaluate the effects of experimental diabetes on the healing period leading to osseointegration. Wistar rats were injected with a single dose of streptozotocin (STZ); body weight and food intake were assessed every 48 hours. On days 2, 12, 26, and 42 post-STZ, glucemia, plasma hemoglobin, and urea were determined. Twelve days post-STZ, a titanium laminar implant was placed in the right tibia of each rat. Two groups of 20 rats each were killed on days 14 and 30 postimplantation, respectively. Results (ANOVA test) showed STZ-treated rats to have 1) a significant decrease in body weight; 2) an increase in food intake; 3) normal hemoglobin and plasma urea values; 4) a significant increase in glucemia; and 5) a decrease in tibiae length. Microscopic evaluation 14 days postimplantation revealed the presence of woven bone, and, at 30 days, laminar bone was in contact with the implant. Our findings show that, in this model of periimplant bone repair and under the experimental conditions stated herein, STZ-induced diabetes retards periimplant bone healing.Fil: Giglio, Maximo Juan Evaristo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Patología y Clinica Bucodental I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Giannunzio, Graciela Ana. Universidad de Buenos Aires. Facultad de Odontología; ArgentinaFil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaLippincott Williams2000-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/44793Giglio, Maximo Juan Evaristo; Giannunzio, Graciela Ana; Olmedo, Daniel Gustavo; Guglielmotti, Maria Beatriz; Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes; Lippincott Williams; Implant Dentistry.; 9; 2; 7-2000; 143-1491056-6163CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/00008505-200009020-00006info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00008505-200009020-00006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:11:34Zoai:ri.conicet.gov.ar:11336/44793instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:11:34.541CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
title Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
spellingShingle Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
Giglio, Maximo Juan Evaristo
Bone Healing
Implants
Diabetes
Osseointegration
title_short Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
title_full Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
title_fullStr Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
title_full_unstemmed Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
title_sort Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes
dc.creator.none.fl_str_mv Giglio, Maximo Juan Evaristo
Giannunzio, Graciela Ana
Olmedo, Daniel Gustavo
Guglielmotti, Maria Beatriz
author Giglio, Maximo Juan Evaristo
author_facet Giglio, Maximo Juan Evaristo
Giannunzio, Graciela Ana
Olmedo, Daniel Gustavo
Guglielmotti, Maria Beatriz
author_role author
author2 Giannunzio, Graciela Ana
Olmedo, Daniel Gustavo
Guglielmotti, Maria Beatriz
author2_role author
author
author
dc.subject.none.fl_str_mv Bone Healing
Implants
Diabetes
Osseointegration
topic Bone Healing
Implants
Diabetes
Osseointegration
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to evaluate the effects of experimental diabetes on the healing period leading to osseointegration. Wistar rats were injected with a single dose of streptozotocin (STZ); body weight and food intake were assessed every 48 hours. On days 2, 12, 26, and 42 post-STZ, glucemia, plasma hemoglobin, and urea were determined. Twelve days post-STZ, a titanium laminar implant was placed in the right tibia of each rat. Two groups of 20 rats each were killed on days 14 and 30 postimplantation, respectively. Results (ANOVA test) showed STZ-treated rats to have 1) a significant decrease in body weight; 2) an increase in food intake; 3) normal hemoglobin and plasma urea values; 4) a significant increase in glucemia; and 5) a decrease in tibiae length. Microscopic evaluation 14 days postimplantation revealed the presence of woven bone, and, at 30 days, laminar bone was in contact with the implant. Our findings show that, in this model of periimplant bone repair and under the experimental conditions stated herein, STZ-induced diabetes retards periimplant bone healing.
Fil: Giglio, Maximo Juan Evaristo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Patología y Clinica Bucodental I; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Giannunzio, Graciela Ana. Universidad de Buenos Aires. Facultad de Odontología; Argentina
Fil: Olmedo, Daniel Gustavo. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Guglielmotti, Maria Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Anatomía Patológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The aim of this study was to evaluate the effects of experimental diabetes on the healing period leading to osseointegration. Wistar rats were injected with a single dose of streptozotocin (STZ); body weight and food intake were assessed every 48 hours. On days 2, 12, 26, and 42 post-STZ, glucemia, plasma hemoglobin, and urea were determined. Twelve days post-STZ, a titanium laminar implant was placed in the right tibia of each rat. Two groups of 20 rats each were killed on days 14 and 30 postimplantation, respectively. Results (ANOVA test) showed STZ-treated rats to have 1) a significant decrease in body weight; 2) an increase in food intake; 3) normal hemoglobin and plasma urea values; 4) a significant increase in glucemia; and 5) a decrease in tibiae length. Microscopic evaluation 14 days postimplantation revealed the presence of woven bone, and, at 30 days, laminar bone was in contact with the implant. Our findings show that, in this model of periimplant bone repair and under the experimental conditions stated herein, STZ-induced diabetes retards periimplant bone healing.
publishDate 2000
dc.date.none.fl_str_mv 2000-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44793
Giglio, Maximo Juan Evaristo; Giannunzio, Graciela Ana; Olmedo, Daniel Gustavo; Guglielmotti, Maria Beatriz; Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes; Lippincott Williams; Implant Dentistry.; 9; 2; 7-2000; 143-149
1056-6163
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44793
identifier_str_mv Giglio, Maximo Juan Evaristo; Giannunzio, Graciela Ana; Olmedo, Daniel Gustavo; Guglielmotti, Maria Beatriz; Histomorphometric Study of Bone Healing Around Laminar Implants in Experimental Diabetes; Lippincott Williams; Implant Dentistry.; 9; 2; 7-2000; 143-149
1056-6163
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/00008505-200009020-00006
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00008505-200009020-00006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270163573932032
score 13.13397

Publicaciones similares