Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
- Autores
- Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; Lioi, Susana; Nannini, Luis J.; Gardeñez, Walter; Bogue, Cristina; Besedovsky, Hugo; del Rey, Adriana; Bottasso, Oscar Adelmo; Bay, Maria Luisa
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.
Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; Argentina
Fil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina - Materia
-
tuberculosis
etiological treatment
immune-endocrine changes
cytokines
adrenal steroids - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/270895
Ver los metadatos del registro completo
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Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatmentBongiovanni, BettinaDíaz, ArianaD'attilio, Luciano DavidSantucci, Natalia EstefaníaDídoli, GriseldaLioi, SusanaNannini, Luis J.Gardeñez, WalterBogue, CristinaBesedovsky, Hugodel Rey, AdrianaBottasso, Oscar AdelmoBay, Maria Luisatuberculosisetiological treatmentimmune-endocrine changescytokinesadrenal steroidshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaFil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; ArgentinaFil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; AlemaniaFil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; AlemaniaFil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaBlackwell Publishing2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270895Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-150077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06643.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06643.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:23Zoai:ri.conicet.gov.ar:11336/270895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:23.839CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
title |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
spellingShingle |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment Bongiovanni, Bettina tuberculosis etiological treatment immune-endocrine changes cytokines adrenal steroids |
title_short |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
title_full |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
title_fullStr |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
title_full_unstemmed |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
title_sort |
Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment |
dc.creator.none.fl_str_mv |
Bongiovanni, Bettina Díaz, Ariana D'attilio, Luciano David Santucci, Natalia Estefanía Dídoli, Griselda Lioi, Susana Nannini, Luis J. Gardeñez, Walter Bogue, Cristina Besedovsky, Hugo del Rey, Adriana Bottasso, Oscar Adelmo Bay, Maria Luisa |
author |
Bongiovanni, Bettina |
author_facet |
Bongiovanni, Bettina Díaz, Ariana D'attilio, Luciano David Santucci, Natalia Estefanía Dídoli, Griselda Lioi, Susana Nannini, Luis J. Gardeñez, Walter Bogue, Cristina Besedovsky, Hugo del Rey, Adriana Bottasso, Oscar Adelmo Bay, Maria Luisa |
author_role |
author |
author2 |
Díaz, Ariana D'attilio, Luciano David Santucci, Natalia Estefanía Dídoli, Griselda Lioi, Susana Nannini, Luis J. Gardeñez, Walter Bogue, Cristina Besedovsky, Hugo del Rey, Adriana Bottasso, Oscar Adelmo Bay, Maria Luisa |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
tuberculosis etiological treatment immune-endocrine changes cytokines adrenal steroids |
topic |
tuberculosis etiological treatment immune-endocrine changes cytokines adrenal steroids |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects. Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina Fil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; Argentina Fil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina Fil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina Fil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; Alemania Fil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; Alemania Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina |
description |
We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/270895 Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-15 0077-8923 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/270895 |
identifier_str_mv |
Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-15 0077-8923 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06643.x info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06643.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Blackwell Publishing |
publisher.none.fl_str_mv |
Blackwell Publishing |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614384058368000 |
score |
13.070432 |