Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment

Autores
Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; Lioi, Susana; Nannini, Luis J.; Gardeñez, Walter; Bogue, Cristina; Besedovsky, Hugo; del Rey, Adriana; Bottasso, Oscar Adelmo; Bay, Maria Luisa
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.
Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; Argentina
Fil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Materia
tuberculosis
etiological treatment
immune-endocrine changes
cytokines
adrenal steroids
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/270895

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatmentBongiovanni, BettinaDíaz, ArianaD'attilio, Luciano DavidSantucci, Natalia EstefaníaDídoli, GriseldaLioi, SusanaNannini, Luis J.Gardeñez, WalterBogue, CristinaBesedovsky, Hugodel Rey, AdrianaBottasso, Oscar AdelmoBay, Maria Luisatuberculosisetiological treatmentimmune-endocrine changescytokinesadrenal steroidshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaFil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; ArgentinaFil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; AlemaniaFil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; AlemaniaFil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaBlackwell Publishing2012-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270895Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-150077-8923CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06643.xinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06643.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:23Zoai:ri.conicet.gov.ar:11336/270895instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:23.839CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
title Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
spellingShingle Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
Bongiovanni, Bettina
tuberculosis
etiological treatment
immune-endocrine changes
cytokines
adrenal steroids
title_short Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
title_full Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
title_fullStr Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
title_full_unstemmed Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
title_sort Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment
dc.creator.none.fl_str_mv Bongiovanni, Bettina
Díaz, Ariana
D'attilio, Luciano David
Santucci, Natalia Estefanía
Dídoli, Griselda
Lioi, Susana
Nannini, Luis J.
Gardeñez, Walter
Bogue, Cristina
Besedovsky, Hugo
del Rey, Adriana
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author Bongiovanni, Bettina
author_facet Bongiovanni, Bettina
Díaz, Ariana
D'attilio, Luciano David
Santucci, Natalia Estefanía
Dídoli, Griselda
Lioi, Susana
Nannini, Luis J.
Gardeñez, Walter
Bogue, Cristina
Besedovsky, Hugo
del Rey, Adriana
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author_role author
author2 Díaz, Ariana
D'attilio, Luciano David
Santucci, Natalia Estefanía
Dídoli, Griselda
Lioi, Susana
Nannini, Luis J.
Gardeñez, Walter
Bogue, Cristina
Besedovsky, Hugo
del Rey, Adriana
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv tuberculosis
etiological treatment
immune-endocrine changes
cytokines
adrenal steroids
topic tuberculosis
etiological treatment
immune-endocrine changes
cytokines
adrenal steroids
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.
Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina
Fil: Dídoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Nannini, Luis J.. Gobierno de la Provincia de Santa Fe. Hospital Escuela Eva Peron; Argentina
Fil: Gardeñez, Walter. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Bogue, Cristina. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Besedovsky, Hugo. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: del Rey, Adriana. Institut Für Physiologie Und Pathophysiologie; Alemania
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
description We evaluated the immune and endocrine status following antituberculosis (TB) treatment in HIV-negative patients Q1 Q2 with newly diagnosed TB. Treatment led to a decrease in IL-6, IL-1, and C-reactive protein levels. Cortisol levels decreased throughout the anti-TB treatment, particularly after four months, but changes were less pronounced than those seen in proinflammatory mediators. Specific therapy resulted in increased dehydroepiandrosterone (DHEA) levels, which peaked after four months and started to decline after six months of treatment, reaching levels below those detected at inclusion. In most patients, DHEAS levels remained unchanged, although a trend to increased concentrations were observed in a few cases three months after the treatment was finished. Specific therapy also resulted in more balanced cortisol/DHEA and cortisol/DHEAS ratios. Etiologic treatment involves favorable immune and endocrine changes, which may account for its beneficial effects.
publishDate 2012
dc.date.none.fl_str_mv 2012-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/270895
Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-15
0077-8923
CONICET Digital
CONICET
url http://hdl.handle.net/11336/270895
identifier_str_mv Bongiovanni, Bettina; Díaz, Ariana; D'attilio, Luciano David; Santucci, Natalia Estefanía; Dídoli, Griselda; et al.; Changes in the immune and endocrine responses of patients with pulmonary tuberculosis undergoing specific treatment; Blackwell Publishing; Annals of the New York Academy of Sciences; 1262; 1; 7-2012; 10-15
0077-8923
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://nyaspubs.onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2012.06643.x
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1749-6632.2012.06643.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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