Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profil...

Autores
Díaz, Ariana; Santucci, Natalia Estefanía; Bongiovanni, Bettina; D'attilio, Luciano David; Massoni, Claudia; Lioi, Susana; Radcliffe, Stella; Didoli, Griselda; Bottasso, Oscar Adelmo; Bay, Maria Luisa
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation. Twenty-four age- and sex-matched healthy controls (HCo) were also included. Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo < 0.05), showing even higher values at T2 (versus T0 < 0.01) and T4 (versus T0 < 0.001). While IL-6, IFN-, TGF- (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9. Tregs correlated positively with IFN- ( = 0.868, < 0.05) at T2 and negatively at T4 ( = −0.795, < 0.05). Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Massoni, Claudia. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Radcliffe, Stella. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Didoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Materia
Pulmonary Tuberculosis
Immune-endocrine interactions
Regulatory T cells
IFN-gamma
Cortisol
DHEA-S
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13501

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profileDíaz, ArianaSantucci, Natalia EstefaníaBongiovanni, BettinaD'attilio, Luciano DavidMassoni, ClaudiaLioi, SusanaRadcliffe, StellaDidoli, GriseldaBottasso, Oscar AdelmoBay, Maria LuisaPulmonary TuberculosisImmune-endocrine interactionsRegulatory T cellsIFN-gammaCortisolDHEA-Shttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation. Twenty-four age- and sex-matched healthy controls (HCo) were also included. Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo < 0.05), showing even higher values at T2 (versus T0 < 0.01) and T4 (versus T0 < 0.001). While IL-6, IFN-, TGF- (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9. Tregs correlated positively with IFN- ( = 0.868, < 0.05) at T2 and negatively at T4 ( = −0.795, < 0.05). Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; ArgentinaFil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; ArgentinaFil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; ArgentinaFil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; ArgentinaFil: Massoni, Claudia. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Radcliffe, Stella. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Didoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaFil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; ArgentinaFil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; ArgentinaHindawi Publishing Corporation2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13501Díaz, Ariana; Santucci, Natalia Estefanía; Bongiovanni, Bettina; D'attilio, Luciano David; Massoni, Claudia; et al.; Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile; Hindawi Publishing Corporation; Journal of Immunology Research; 2015; -1-2015; 1-8; 9853022314-88612314-7156enginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2015/985302info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2015/985302/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:38Zoai:ri.conicet.gov.ar:11336/13501instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:38.462CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
title Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
spellingShingle Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
Díaz, Ariana
Pulmonary Tuberculosis
Immune-endocrine interactions
Regulatory T cells
IFN-gamma
Cortisol
DHEA-S
title_short Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
title_full Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
title_fullStr Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
title_full_unstemmed Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
title_sort Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile
dc.creator.none.fl_str_mv Díaz, Ariana
Santucci, Natalia Estefanía
Bongiovanni, Bettina
D'attilio, Luciano David
Massoni, Claudia
Lioi, Susana
Radcliffe, Stella
Didoli, Griselda
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author Díaz, Ariana
author_facet Díaz, Ariana
Santucci, Natalia Estefanía
Bongiovanni, Bettina
D'attilio, Luciano David
Massoni, Claudia
Lioi, Susana
Radcliffe, Stella
Didoli, Griselda
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author_role author
author2 Santucci, Natalia Estefanía
Bongiovanni, Bettina
D'attilio, Luciano David
Massoni, Claudia
Lioi, Susana
Radcliffe, Stella
Didoli, Griselda
Bottasso, Oscar Adelmo
Bay, Maria Luisa
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pulmonary Tuberculosis
Immune-endocrine interactions
Regulatory T cells
IFN-gamma
Cortisol
DHEA-S
topic Pulmonary Tuberculosis
Immune-endocrine interactions
Regulatory T cells
IFN-gamma
Cortisol
DHEA-S
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation. Twenty-four age- and sex-matched healthy controls (HCo) were also included. Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo < 0.05), showing even higher values at T2 (versus T0 < 0.01) and T4 (versus T0 < 0.001). While IL-6, IFN-, TGF- (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9. Tregs correlated positively with IFN- ( = 0.868, < 0.05) at T2 and negatively at T4 ( = −0.795, < 0.05). Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
Fil: Díaz, Ariana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Santucci, Natalia Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Bongiovanni, Bettina. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: D'attilio, Luciano David. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Massoni, Claudia. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Lioi, Susana. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Radcliffe, Stella. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; Argentina
Fil: Didoli, Griselda. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico Rosario; Argentina
Fil: Bay, Maria Luisa. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina
description Tuberculosis (TB) is a major health problem requiring an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in IR regulation, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients, 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6), and 9 months following treatment initiation. Twenty-four age- and sex-matched healthy controls (HCo) were also included. Tregs (flow cytometry) from TB patients were increased at T0 (versus HCo < 0.05), showing even higher values at T2 (versus T0 < 0.01) and T4 (versus T0 < 0.001). While IL-6, IFN-, TGF- (ELISA), and Cortisol (electrochemiluminescence, EQ) were augmented, DHEA-S (EQ) levels were diminished at T0 with respect to HCo, with cytokines and Cortisol returning to normal values at T9. Tregs correlated positively with IFN- ( = 0.868, < 0.05) at T2 and negatively at T4 ( = −0.795, < 0.05). Lowered levels of proinflammatory cytokines together with an increased frequency of Tregs of patients undergoing specific treatment might reflect a downmodulatory effect of these cells on the accompanying inflammation.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13501
Díaz, Ariana; Santucci, Natalia Estefanía; Bongiovanni, Bettina; D'attilio, Luciano David; Massoni, Claudia; et al.; Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile; Hindawi Publishing Corporation; Journal of Immunology Research; 2015; -1-2015; 1-8; 985302
2314-8861
2314-7156
url http://hdl.handle.net/11336/13501
identifier_str_mv Díaz, Ariana; Santucci, Natalia Estefanía; Bongiovanni, Bettina; D'attilio, Luciano David; Massoni, Claudia; et al.; Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary Tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile; Hindawi Publishing Corporation; Journal of Immunology Research; 2015; -1-2015; 1-8; 985302
2314-8861
2314-7156
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/985302
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2015/985302/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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