Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex

Autores
Santos, Pablo Sandro Carvalho; Füst, George; Prohászka, Zoltán; Volz, Armin; Horton, Roger; Miretti, Marcos Mateo; Yu, Chack-Yung; Beck, Stephan G.; Uchanska-Ziegler, Barbara; Ziegler, Andreas
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women. © Copyright 2008, Mary Ann Liebert, Inc. 2008.
Fil: Santos, Pablo Sandro Carvalho. Charité – Universitätsmedizin Berlin;
Fil: Füst, George. Semmelweis Egyetem;
Fil: Prohászka, Zoltán. Magyar Tudomanyos Akademia; . Semmelweis Egyetem;
Fil: Volz, Armin. Charité – Universitätsmedizin Berlin;
Fil: Horton, Roger. Wellcome Trust Sanger Institute;
Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Wellcome Trust Sanger Institute;
Fil: Yu, Chack-Yung. Ohio State University; Estados Unidos
Fil: Beck, Stephan G.. Ucl Cancer Institute;
Fil: Uchanska-Ziegler, Barbara. Charité – Universitätsmedizin Berlin;
Fil: Ziegler, Andreas. Charité – Universitätsmedizin Berlin;
Materia
Hla Haplotype
Smoking
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/60931
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/60931
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complexSantos, Pablo Sandro CarvalhoFüst, GeorgeProhászka, ZoltánVolz, ArminHorton, RogerMiretti, Marcos MateoYu, Chack-YungBeck, Stephan G.Uchanska-Ziegler, BarbaraZiegler, AndreasHla HaplotypeSmokinghttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women. © Copyright 2008, Mary Ann Liebert, Inc. 2008.Fil: Santos, Pablo Sandro Carvalho. Charité – Universitätsmedizin Berlin;Fil: Füst, George. Semmelweis Egyetem;Fil: Prohászka, Zoltán. Magyar Tudomanyos Akademia; . Semmelweis Egyetem;Fil: Volz, Armin. Charité – Universitätsmedizin Berlin;Fil: Horton, Roger. Wellcome Trust Sanger Institute;Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Wellcome Trust Sanger Institute;Fil: Yu, Chack-Yung. Ohio State University; Estados UnidosFil: Beck, Stephan G.. Ucl Cancer Institute;Fil: Uchanska-Ziegler, Barbara. Charité – Universitätsmedizin Berlin;Fil: Ziegler, Andreas. Charité – Universitätsmedizin Berlin;Mary Ann Liebert2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/60931Santos, Pablo Sandro Carvalho; Füst, George; Prohászka, Zoltán; Volz, Armin; Horton, Roger; et al.; Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex; Mary Ann Liebert; Genetic Testing; 12; 4; 12-2008; 481-4861090-6576CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/gte.2008.0029info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:45Zoai:ri.conicet.gov.ar:11336/60931instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:46.139CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
title Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
spellingShingle Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
Santos, Pablo Sandro Carvalho
Hla Haplotype
Smoking
title_short Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
title_full Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
title_fullStr Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
title_full_unstemmed Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
title_sort Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex
dc.creator.none.fl_str_mv Santos, Pablo Sandro Carvalho
Füst, George
Prohászka, Zoltán
Volz, Armin
Horton, Roger
Miretti, Marcos Mateo
Yu, Chack-Yung
Beck, Stephan G.
Uchanska-Ziegler, Barbara
Ziegler, Andreas
author Santos, Pablo Sandro Carvalho
author_facet Santos, Pablo Sandro Carvalho
Füst, George
Prohászka, Zoltán
Volz, Armin
Horton, Roger
Miretti, Marcos Mateo
Yu, Chack-Yung
Beck, Stephan G.
Uchanska-Ziegler, Barbara
Ziegler, Andreas
author_role author
author2 Füst, George
Prohászka, Zoltán
Volz, Armin
Horton, Roger
Miretti, Marcos Mateo
Yu, Chack-Yung
Beck, Stephan G.
Uchanska-Ziegler, Barbara
Ziegler, Andreas
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hla Haplotype
Smoking
topic Hla Haplotype
Smoking
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women. © Copyright 2008, Mary Ann Liebert, Inc. 2008.
Fil: Santos, Pablo Sandro Carvalho. Charité – Universitätsmedizin Berlin;
Fil: Füst, George. Semmelweis Egyetem;
Fil: Prohászka, Zoltán. Magyar Tudomanyos Akademia; . Semmelweis Egyetem;
Fil: Volz, Armin. Charité – Universitätsmedizin Berlin;
Fil: Horton, Roger. Wellcome Trust Sanger Institute;
Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Wellcome Trust Sanger Institute;
Fil: Yu, Chack-Yung. Ohio State University; Estados Unidos
Fil: Beck, Stephan G.. Ucl Cancer Institute;
Fil: Uchanska-Ziegler, Barbara. Charité – Universitätsmedizin Berlin;
Fil: Ziegler, Andreas. Charité – Universitätsmedizin Berlin;
description Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971T) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a 97Thr→Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971T allele (p=1.05×10-2), with higher significance than with A1-B8-DR3 (p=2.38×10-2). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971T polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women. © Copyright 2008, Mary Ann Liebert, Inc. 2008.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/60931
Santos, Pablo Sandro Carvalho; Füst, George; Prohászka, Zoltán; Volz, Armin; Horton, Roger; et al.; Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex; Mary Ann Liebert; Genetic Testing; 12; 4; 12-2008; 481-486
1090-6576
CONICET Digital
CONICET
url http://hdl.handle.net/11336/60931
identifier_str_mv Santos, Pablo Sandro Carvalho; Füst, George; Prohászka, Zoltán; Volz, Armin; Horton, Roger; et al.; Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex; Mary Ann Liebert; Genetic Testing; 12; 4; 12-2008; 481-486
1090-6576
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/gte.2008.0029
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082651934425088
score 13.22299

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