All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression

Autores
Martire Greco, Daiana; Landoni, Verónica Inés; Chiarella, Paula; Rodriguez Rodrigues, Nahuel Emiliano; Schierloh, Luis Pablo; Rearte, María Bárbara; Isturiz, Martín Amadeo; Fernández, Gabriela Cristina
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Secondary infections due to post-sepsis immunosuppression is a major cause of death in septic patients. Strategies aimed at restoring immune functions offer a new perspective. We used LPS-immunosuppressed (IS) mice to analyze the effects of all-trans Retinoic Acid (ATRA) on different immune parameters. IS mice showed decreased lymphocyte and increased myeloid-derived suppressor cells (MDSC) counts in lymph nodes. They also showed an impaired in vitro T cell proliferation,mediated by MDSC. ATRA administration restored T cell proliferation, associated to a decreased number of live MDSC. IS mice treated with ATRA showed an increased number of CD4+ and CD8+ T cells. ATRA partially improved the primary humoral immune response, even when the immunossuppression was first established, and ATRA administered afterwards. Our results demonstrate that ATRA restores immunocompetence, modulating the number of leukocytes and the survival of MDSC,representing a supplementary potential strategy in the treatment of the immunosuppressive state of sepsis.
Fil: Martire Greco, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landoni, Verónica Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Rodriguez Rodrigues, Nahuel Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Schierloh, Luis Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Rearte, María Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
All-Trans-Retinoic Acid (Atra)
Immunosuppression
Lipopolysaccharide (Lps)
Myeloid-Derived Suppressor Cell (Mdsc)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21062
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/21062
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppressionMartire Greco, DaianaLandoni, Verónica InésChiarella, PaulaRodriguez Rodrigues, Nahuel EmilianoSchierloh, Luis PabloRearte, María BárbaraIsturiz, Martín AmadeoFernández, Gabriela CristinaAll-Trans-Retinoic Acid (Atra)ImmunosuppressionLipopolysaccharide (Lps)Myeloid-Derived Suppressor Cell (Mdsc)https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Secondary infections due to post-sepsis immunosuppression is a major cause of death in septic patients. Strategies aimed at restoring immune functions offer a new perspective. We used LPS-immunosuppressed (IS) mice to analyze the effects of all-trans Retinoic Acid (ATRA) on different immune parameters. IS mice showed decreased lymphocyte and increased myeloid-derived suppressor cells (MDSC) counts in lymph nodes. They also showed an impaired in vitro T cell proliferation,mediated by MDSC. ATRA administration restored T cell proliferation, associated to a decreased number of live MDSC. IS mice treated with ATRA showed an increased number of CD4+ and CD8+ T cells. ATRA partially improved the primary humoral immune response, even when the immunossuppression was first established, and ATRA administered afterwards. Our results demonstrate that ATRA restores immunocompetence, modulating the number of leukocytes and the survival of MDSC,representing a supplementary potential strategy in the treatment of the immunosuppressive state of sepsis.Fil: Martire Greco, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Landoni, Verónica Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Rodriguez Rodrigues, Nahuel Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Schierloh, Luis Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Rearte, María Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaPortland Press2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21062Martire Greco, Daiana; Landoni, Verónica Inés; Chiarella, Paula; Rodriguez Rodrigues, Nahuel Emiliano; Schierloh, Luis Pablo; et al.; All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression; Portland Press; Clinical Science; 126; 5; 3-2014; 355-3650143-5221CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.clinsci.org/content/126/5/355info:eu-repo/semantics/altIdentifier/doi/10.1042/CS20130236info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:03Zoai:ri.conicet.gov.ar:11336/21062instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:03.323CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
title All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
spellingShingle All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
Martire Greco, Daiana
All-Trans-Retinoic Acid (Atra)
Immunosuppression
Lipopolysaccharide (Lps)
Myeloid-Derived Suppressor Cell (Mdsc)
title_short All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
title_full All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
title_fullStr All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
title_full_unstemmed All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
title_sort All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression
dc.creator.none.fl_str_mv Martire Greco, Daiana
Landoni, Verónica Inés
Chiarella, Paula
Rodriguez Rodrigues, Nahuel Emiliano
Schierloh, Luis Pablo
Rearte, María Bárbara
Isturiz, Martín Amadeo
Fernández, Gabriela Cristina
author Martire Greco, Daiana
author_facet Martire Greco, Daiana
Landoni, Verónica Inés
Chiarella, Paula
Rodriguez Rodrigues, Nahuel Emiliano
Schierloh, Luis Pablo
Rearte, María Bárbara
Isturiz, Martín Amadeo
Fernández, Gabriela Cristina
author_role author
author2 Landoni, Verónica Inés
Chiarella, Paula
Rodriguez Rodrigues, Nahuel Emiliano
Schierloh, Luis Pablo
Rearte, María Bárbara
Isturiz, Martín Amadeo
Fernández, Gabriela Cristina
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv All-Trans-Retinoic Acid (Atra)
Immunosuppression
Lipopolysaccharide (Lps)
Myeloid-Derived Suppressor Cell (Mdsc)
topic All-Trans-Retinoic Acid (Atra)
Immunosuppression
Lipopolysaccharide (Lps)
Myeloid-Derived Suppressor Cell (Mdsc)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Secondary infections due to post-sepsis immunosuppression is a major cause of death in septic patients. Strategies aimed at restoring immune functions offer a new perspective. We used LPS-immunosuppressed (IS) mice to analyze the effects of all-trans Retinoic Acid (ATRA) on different immune parameters. IS mice showed decreased lymphocyte and increased myeloid-derived suppressor cells (MDSC) counts in lymph nodes. They also showed an impaired in vitro T cell proliferation,mediated by MDSC. ATRA administration restored T cell proliferation, associated to a decreased number of live MDSC. IS mice treated with ATRA showed an increased number of CD4+ and CD8+ T cells. ATRA partially improved the primary humoral immune response, even when the immunossuppression was first established, and ATRA administered afterwards. Our results demonstrate that ATRA restores immunocompetence, modulating the number of leukocytes and the survival of MDSC,representing a supplementary potential strategy in the treatment of the immunosuppressive state of sepsis.
Fil: Martire Greco, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landoni, Verónica Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Chiarella, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Rodriguez Rodrigues, Nahuel Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Schierloh, Luis Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Rearte, María Bárbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Isturiz, Martín Amadeo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Fernández, Gabriela Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description Secondary infections due to post-sepsis immunosuppression is a major cause of death in septic patients. Strategies aimed at restoring immune functions offer a new perspective. We used LPS-immunosuppressed (IS) mice to analyze the effects of all-trans Retinoic Acid (ATRA) on different immune parameters. IS mice showed decreased lymphocyte and increased myeloid-derived suppressor cells (MDSC) counts in lymph nodes. They also showed an impaired in vitro T cell proliferation,mediated by MDSC. ATRA administration restored T cell proliferation, associated to a decreased number of live MDSC. IS mice treated with ATRA showed an increased number of CD4+ and CD8+ T cells. ATRA partially improved the primary humoral immune response, even when the immunossuppression was first established, and ATRA administered afterwards. Our results demonstrate that ATRA restores immunocompetence, modulating the number of leukocytes and the survival of MDSC,representing a supplementary potential strategy in the treatment of the immunosuppressive state of sepsis.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21062
Martire Greco, Daiana; Landoni, Verónica Inés; Chiarella, Paula; Rodriguez Rodrigues, Nahuel Emiliano; Schierloh, Luis Pablo; et al.; All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression; Portland Press; Clinical Science; 126; 5; 3-2014; 355-365
0143-5221
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21062
identifier_str_mv Martire Greco, Daiana; Landoni, Verónica Inés; Chiarella, Paula; Rodriguez Rodrigues, Nahuel Emiliano; Schierloh, Luis Pablo; et al.; All-trans-retinoic acid improves immunocompetence in a murine model of lipopolysaccharide-induced immunosuppression; Portland Press; Clinical Science; 126; 5; 3-2014; 355-365
0143-5221
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.clinsci.org/content/126/5/355
info:eu-repo/semantics/altIdentifier/doi/10.1042/CS20130236
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
application/pdf
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application/pdf
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dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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