The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells

Autores
Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Cabrera, Gabriel Gustavo; Vermeulen, Elba Monica; de la Cruz Merino, Luis; Sánchez Margalet, Victor
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population.
Fil: Sánchez León, María Luisa. Universidad de Sevilla; España
Fil: Jiménez Cortegana, Carlos. Universidad de Sevilla; España
Fil: Cabrera, Gabriel Gustavo. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: de la Cruz Merino, Luis. Universidad de Sevilla; España
Fil: Sánchez Margalet, Victor. Universidad de Sevilla; España
Materia
CANCER
DENDRITIC CELLS
IMMUNOSUPPRESSION
MYELOID-DERIVED SUPPRESSOR CELLS
VACCINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/210661
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/210661
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cellsSánchez León, María LuisaJiménez Cortegana, CarlosCabrera, Gabriel GustavoVermeulen, Elba Monicade la Cruz Merino, LuisSánchez Margalet, VictorCANCERDENDRITIC CELLSIMMUNOSUPPRESSIONMYELOID-DERIVED SUPPRESSOR CELLSVACCINEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population.Fil: Sánchez León, María Luisa. Universidad de Sevilla; EspañaFil: Jiménez Cortegana, Carlos. Universidad de Sevilla; EspañaFil: Cabrera, Gabriel Gustavo. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: de la Cruz Merino, Luis. Universidad de Sevilla; EspañaFil: Sánchez Margalet, Victor. Universidad de Sevilla; EspañaFrontiers Media2022-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/210661Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Cabrera, Gabriel Gustavo; Vermeulen, Elba Monica; de la Cruz Merino, Luis; et al.; The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells; Frontiers Media; Frontiers in Immunology; 13; 11-2022; 1-151664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.1050484info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:05Zoai:ri.conicet.gov.ar:11336/210661instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:05.446CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
title The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
spellingShingle The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
Sánchez León, María Luisa
CANCER
DENDRITIC CELLS
IMMUNOSUPPRESSION
MYELOID-DERIVED SUPPRESSOR CELLS
VACCINES
title_short The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
title_full The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
title_fullStr The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
title_full_unstemmed The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
title_sort The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells
dc.creator.none.fl_str_mv Sánchez León, María Luisa
Jiménez Cortegana, Carlos
Cabrera, Gabriel Gustavo
Vermeulen, Elba Monica
de la Cruz Merino, Luis
Sánchez Margalet, Victor
author Sánchez León, María Luisa
author_facet Sánchez León, María Luisa
Jiménez Cortegana, Carlos
Cabrera, Gabriel Gustavo
Vermeulen, Elba Monica
de la Cruz Merino, Luis
Sánchez Margalet, Victor
author_role author
author2 Jiménez Cortegana, Carlos
Cabrera, Gabriel Gustavo
Vermeulen, Elba Monica
de la Cruz Merino, Luis
Sánchez Margalet, Victor
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CANCER
DENDRITIC CELLS
IMMUNOSUPPRESSION
MYELOID-DERIVED SUPPRESSOR CELLS
VACCINES
topic CANCER
DENDRITIC CELLS
IMMUNOSUPPRESSION
MYELOID-DERIVED SUPPRESSOR CELLS
VACCINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population.
Fil: Sánchez León, María Luisa. Universidad de Sevilla; España
Fil: Jiménez Cortegana, Carlos. Universidad de Sevilla; España
Fil: Cabrera, Gabriel Gustavo. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vermeulen, Elba Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: de la Cruz Merino, Luis. Universidad de Sevilla; España
Fil: Sánchez Margalet, Victor. Universidad de Sevilla; España
description Dendritic cells (DCs) are a heterogenous population of professional antigen presenting cells whose main role is diminished in a variety of malignancies, including cancer, leading to ineffective immune responses. Those mechanisms are inhibited due to the immunosuppressive conditions found in the tumor microenvironment (TME), where myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells known to play a key role in tumor immunoevasion by inhibiting T-cell responses, are extremely accumulated. In addition, it has been demonstrated that MDSCs not only suppress DC functions, but also their maturation and development within the myeloid linage. Considering that an increased number of DCs as well as the improvement in their functions boost antitumor immunity, DC-based vaccines were developed two decades ago, and promising results have been obtained throughout these years. Therefore, the remodeling of the TME promoted by DC vaccination has also been explored. Here, we aim to review the effectiveness of different DCs-based vaccines in murine models and cancer patients, either alone or synergistically combined with other treatments, being especially focused on their effect on the MDSC population.
publishDate 2022
dc.date.none.fl_str_mv 2022-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/210661
Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Cabrera, Gabriel Gustavo; Vermeulen, Elba Monica; de la Cruz Merino, Luis; et al.; The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells; Frontiers Media; Frontiers in Immunology; 13; 11-2022; 1-15
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/210661
identifier_str_mv Sánchez León, María Luisa; Jiménez Cortegana, Carlos; Cabrera, Gabriel Gustavo; Vermeulen, Elba Monica; de la Cruz Merino, Luis; et al.; The effects of dendritic cell-based vaccines in the tumor microenvironment: Impact on myeloid-derived suppressor cells; Frontiers Media; Frontiers in Immunology; 13; 11-2022; 1-15
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2022.1050484
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269383013957632
score 13.13397

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