Sialic Acids in Health and Disease

Autores
Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; Boskovic, Danilo S.
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.
Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University;
Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zhang, Guangyu. Loma Linda University (llu);
Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina
Fil: Boskovic, Danilo S.. Loma Linda University (llu);
Materia
SIALIC ACID
N-Glycolylneuraminic acid
Neu5Ac
Neu5Gc
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265007
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Sialic Acids in Health and DiseaseGuerrero Flores, Gerardo NatanielButler, Fayth M.Martinez Marignac, Veronica LucreciaZhang, GuangyuPacheco, Fabio JulianoBoskovic, Danilo S.SIALIC ACIDN-Glycolylneuraminic acidNeu5AcNeu5Gchttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University;Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zhang, Guangyu. Loma Linda University (llu);Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; ArgentinaFil: Boskovic, Danilo S.. Loma Linda University (llu);MDPI2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265007Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-432673-8449CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-8449/5/2/10info:eu-repo/semantics/altIdentifier/doi/10.3390/biologics5020010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:58:27Zoai:ri.conicet.gov.ar:11336/265007instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:58:27.798CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sialic Acids in Health and Disease
title Sialic Acids in Health and Disease
spellingShingle Sialic Acids in Health and Disease
Guerrero Flores, Gerardo Nataniel
SIALIC ACID
N-Glycolylneuraminic acid
Neu5Ac
Neu5Gc
title_short Sialic Acids in Health and Disease
title_full Sialic Acids in Health and Disease
title_fullStr Sialic Acids in Health and Disease
title_full_unstemmed Sialic Acids in Health and Disease
title_sort Sialic Acids in Health and Disease
dc.creator.none.fl_str_mv Guerrero Flores, Gerardo Nataniel
Butler, Fayth M.
Martinez Marignac, Veronica Lucrecia
Zhang, Guangyu
Pacheco, Fabio Juliano
Boskovic, Danilo S.
author Guerrero Flores, Gerardo Nataniel
author_facet Guerrero Flores, Gerardo Nataniel
Butler, Fayth M.
Martinez Marignac, Veronica Lucrecia
Zhang, Guangyu
Pacheco, Fabio Juliano
Boskovic, Danilo S.
author_role author
author2 Butler, Fayth M.
Martinez Marignac, Veronica Lucrecia
Zhang, Guangyu
Pacheco, Fabio Juliano
Boskovic, Danilo S.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv SIALIC ACID
N-Glycolylneuraminic acid
Neu5Ac
Neu5Gc
topic SIALIC ACID
N-Glycolylneuraminic acid
Neu5Ac
Neu5Gc
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.
Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University;
Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zhang, Guangyu. Loma Linda University (llu);
Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina
Fil: Boskovic, Danilo S.. Loma Linda University (llu);
description Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.
publishDate 2025
dc.date.none.fl_str_mv 2025-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265007
Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-43
2673-8449
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265007
identifier_str_mv Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-43
2673-8449
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-8449/5/2/10
info:eu-repo/semantics/altIdentifier/doi/10.3390/biologics5020010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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