Sialic Acids in Health and Disease
- Autores
- Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; Boskovic, Danilo S.
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.
Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina
Fil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University;
Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Zhang, Guangyu. Loma Linda University (llu);
Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina
Fil: Boskovic, Danilo S.. Loma Linda University (llu); - Materia
-
SIALIC ACID
N-Glycolylneuraminic acid
Neu5Ac
Neu5Gc - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/265007
Ver los metadatos del registro completo
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Sialic Acids in Health and DiseaseGuerrero Flores, Gerardo NatanielButler, Fayth M.Martinez Marignac, Veronica LucreciaZhang, GuangyuPacheco, Fabio JulianoBoskovic, Danilo S.SIALIC ACIDN-Glycolylneuraminic acidNeu5AcNeu5Gchttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed.Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; ArgentinaFil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University;Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zhang, Guangyu. Loma Linda University (llu);Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; ArgentinaFil: Boskovic, Danilo S.. Loma Linda University (llu);MDPI2025-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265007Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-432673-8449CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-8449/5/2/10info:eu-repo/semantics/altIdentifier/doi/10.3390/biologics5020010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:35Zoai:ri.conicet.gov.ar:11336/265007instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:35.898CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Sialic Acids in Health and Disease |
title |
Sialic Acids in Health and Disease |
spellingShingle |
Sialic Acids in Health and Disease Guerrero Flores, Gerardo Nataniel SIALIC ACID N-Glycolylneuraminic acid Neu5Ac Neu5Gc |
title_short |
Sialic Acids in Health and Disease |
title_full |
Sialic Acids in Health and Disease |
title_fullStr |
Sialic Acids in Health and Disease |
title_full_unstemmed |
Sialic Acids in Health and Disease |
title_sort |
Sialic Acids in Health and Disease |
dc.creator.none.fl_str_mv |
Guerrero Flores, Gerardo Nataniel Butler, Fayth M. Martinez Marignac, Veronica Lucrecia Zhang, Guangyu Pacheco, Fabio Juliano Boskovic, Danilo S. |
author |
Guerrero Flores, Gerardo Nataniel |
author_facet |
Guerrero Flores, Gerardo Nataniel Butler, Fayth M. Martinez Marignac, Veronica Lucrecia Zhang, Guangyu Pacheco, Fabio Juliano Boskovic, Danilo S. |
author_role |
author |
author2 |
Butler, Fayth M. Martinez Marignac, Veronica Lucrecia Zhang, Guangyu Pacheco, Fabio Juliano Boskovic, Danilo S. |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
SIALIC ACID N-Glycolylneuraminic acid Neu5Ac Neu5Gc |
topic |
SIALIC ACID N-Glycolylneuraminic acid Neu5Ac Neu5Gc |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed. Fil: Guerrero Flores, Gerardo Nataniel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Butler, Fayth M.. Center For Nutrition, Lifestyle And Disease Prevention ; School Of Public Health ; Loma Linda University; Fil: Martinez Marignac, Veronica Lucrecia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zhang, Guangyu. Loma Linda University (llu); Fil: Pacheco, Fabio Juliano. Universidad Adventista del Plata. Secretaría de Ciencia y Técnica. Centro Interdisciplinario de Investigaciones En Ciencias de la Salud y del Comportamiento.; Argentina Fil: Boskovic, Danilo S.. Loma Linda University (llu); |
description |
Vertebrate cell surfaces exhibit intricate arrangements of glycosaminoglycan polymers, which are primarily linked to lipids and proteins. Numerous soluble secreted proteins are also decorated with either individual sugar molecules or their polymers. The carbohydrate polymers commonly possess terminal nine-carbon sugars, known as sialic acids. Due to their widespread distribution and strategic positioning, sialic acids play a crucial role in mediating and regulating a wide range of physiologic processes and pathologic conditions. Human- or animal-based investigations predominantly concentrate on the effects of sialic acids during infections, inflammations, vascular disorders, or cancers. Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. Nevertheless, future mechanistic investigations are needed to clarify the specific roles of sialic acids in these varied contexts, so that more effective interventions may be developed. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/265007 Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-43 2673-8449 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/265007 |
identifier_str_mv |
Guerrero Flores, Gerardo Nataniel; Butler, Fayth M.; Martinez Marignac, Veronica Lucrecia; Zhang, Guangyu; Pacheco, Fabio Juliano; et al.; Sialic Acids in Health and Disease; MDPI; Biologics; 5; 2; 3-2025; 1-43 2673-8449 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2673-8449/5/2/10 info:eu-repo/semantics/altIdentifier/doi/10.3390/biologics5020010 |
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info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
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MDPI |
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MDPI |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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