Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?

Autores
García, Carlos; Aroca Martinez, Gustavo; Velez Verbel, María de los Ángeles; Martinez, Álvaro; Sepulveda, Carlos; Roncallo, Camilo; Gutierrez Campo, Valentina; Barraza Ahumada, Natalia; Terrasa, Sergio Adrian; Musso, Carlos
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune chronic multi-organic diseasecharacterized by a deregulated innate and adaptive response. A series of viral and bacterial agentshave been associated with SLE activation. Coronavirus family represents important infectiouspathogens in both humans and animals, being responsible for approximately one third of community acquired superior respiratory tract infections. At the end of 2019, a new coronavirus (SARS-CoV-2) was detected as responsible for the COVID-19 disease. It was decided to evaluate if SLE patients had a greater risk of lupus activation when contracting COVID-19.Material & Method: Sixty two COVID-19 infected SLE patients were studied, comparing thosewho had suffered lupus reactivation versus those who had not. Renal function, autoinmunity andinflammation markers, and SLE reactivation risk was compared between both groups.Result: COVID-19 infection in SLE patients did not elevate lupus reactivation risk: OR: 0.8 (0.3-2.6), p: 0.7.Conclusion: COVID-19 is not, at the moment and as documented, a risk factor for SLE reactivation.
Fil: García, Carlos. Clínica de la Costa; Colombia. Universidad Simon Bolivar; Colombia
Fil: Aroca Martinez, Gustavo. Universidad Simon Bolivar; Colombia. Clínica de la Costa; Colombia
Fil: Velez Verbel, María de los Ángeles. Universidad Simon Bolivar; Colombia. Clínica de la Costa; Colombia
Fil: Martinez, Álvaro. Clínica de la Costa; Colombia
Fil: Sepulveda, Carlos. Clínica de la Costa; Colombia
Fil: Roncallo, Camilo. Clínica de la Costa; Colombia
Fil: Gutierrez Campo, Valentina. Clínica de la Costa; Colombia. Universidad Metropolitana; Colombia
Fil: Barraza Ahumada, Natalia. Clínica de la Costa; Colombia
Fil: Terrasa, Sergio Adrian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Musso, Carlos. Hospital Italiano. Departamento de Medicina.; Argentina. Universidad Simon Bolivar; Colombia
Materia
systemic Lupus erythematosus
activation
covid-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/219815
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/219815
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?García, CarlosAroca Martinez, GustavoVelez Verbel, María de los ÁngelesMartinez, ÁlvaroSepulveda, CarlosRoncallo, CamiloGutierrez Campo, ValentinaBarraza Ahumada, NataliaTerrasa, Sergio AdrianMusso, Carlossystemic Lupus erythematosusactivationcovid-19https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Systemic lupus erythematosus (SLE) is an autoimmune chronic multi-organic diseasecharacterized by a deregulated innate and adaptive response. A series of viral and bacterial agentshave been associated with SLE activation. Coronavirus family represents important infectiouspathogens in both humans and animals, being responsible for approximately one third of community acquired superior respiratory tract infections. At the end of 2019, a new coronavirus (SARS-CoV-2) was detected as responsible for the COVID-19 disease. It was decided to evaluate if SLE patients had a greater risk of lupus activation when contracting COVID-19.Material & Method: Sixty two COVID-19 infected SLE patients were studied, comparing thosewho had suffered lupus reactivation versus those who had not. Renal function, autoinmunity andinflammation markers, and SLE reactivation risk was compared between both groups.Result: COVID-19 infection in SLE patients did not elevate lupus reactivation risk: OR: 0.8 (0.3-2.6), p: 0.7.Conclusion: COVID-19 is not, at the moment and as documented, a risk factor for SLE reactivation.Fil: García, Carlos. Clínica de la Costa; Colombia. Universidad Simon Bolivar; ColombiaFil: Aroca Martinez, Gustavo. Universidad Simon Bolivar; Colombia. Clínica de la Costa; ColombiaFil: Velez Verbel, María de los Ángeles. Universidad Simon Bolivar; Colombia. Clínica de la Costa; ColombiaFil: Martinez, Álvaro. Clínica de la Costa; ColombiaFil: Sepulveda, Carlos. Clínica de la Costa; ColombiaFil: Roncallo, Camilo. Clínica de la Costa; ColombiaFil: Gutierrez Campo, Valentina. Clínica de la Costa; Colombia. Universidad Metropolitana; ColombiaFil: Barraza Ahumada, Natalia. Clínica de la Costa; ColombiaFil: Terrasa, Sergio Adrian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Musso, Carlos. Hospital Italiano. Departamento de Medicina.; Argentina. Universidad Simon Bolivar; ColombiaInternational Journal Of Medical Science And Clinical Research Studies2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/219815García, Carlos; Aroca Martinez, Gustavo; Velez Verbel, María de los Ángeles; Martinez, Álvaro; Sepulveda, Carlos; et al.; Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?; International Journal Of Medical Science And Clinical Research Studies; International Journal Of Medical Science And Clinical Research Studies; 3; 3; 3-2023; 343-3482767-83262767-8342CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ijmscr.org/index.php/ijmscrs/article/view/641info:eu-repo/semantics/altIdentifier/doi/10.47191/ijmscrs/v3-i3-13info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:02Zoai:ri.conicet.gov.ar:11336/219815instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:02.929CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
title Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
spellingShingle Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
García, Carlos
systemic Lupus erythematosus
activation
covid-19
title_short Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
title_full Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
title_fullStr Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
title_full_unstemmed Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
title_sort Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?
dc.creator.none.fl_str_mv García, Carlos
Aroca Martinez, Gustavo
Velez Verbel, María de los Ángeles
Martinez, Álvaro
Sepulveda, Carlos
Roncallo, Camilo
Gutierrez Campo, Valentina
Barraza Ahumada, Natalia
Terrasa, Sergio Adrian
Musso, Carlos
author García, Carlos
author_facet García, Carlos
Aroca Martinez, Gustavo
Velez Verbel, María de los Ángeles
Martinez, Álvaro
Sepulveda, Carlos
Roncallo, Camilo
Gutierrez Campo, Valentina
Barraza Ahumada, Natalia
Terrasa, Sergio Adrian
Musso, Carlos
author_role author
author2 Aroca Martinez, Gustavo
Velez Verbel, María de los Ángeles
Martinez, Álvaro
Sepulveda, Carlos
Roncallo, Camilo
Gutierrez Campo, Valentina
Barraza Ahumada, Natalia
Terrasa, Sergio Adrian
Musso, Carlos
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv systemic Lupus erythematosus
activation
covid-19
topic systemic Lupus erythematosus
activation
covid-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Systemic lupus erythematosus (SLE) is an autoimmune chronic multi-organic diseasecharacterized by a deregulated innate and adaptive response. A series of viral and bacterial agentshave been associated with SLE activation. Coronavirus family represents important infectiouspathogens in both humans and animals, being responsible for approximately one third of community acquired superior respiratory tract infections. At the end of 2019, a new coronavirus (SARS-CoV-2) was detected as responsible for the COVID-19 disease. It was decided to evaluate if SLE patients had a greater risk of lupus activation when contracting COVID-19.Material & Method: Sixty two COVID-19 infected SLE patients were studied, comparing thosewho had suffered lupus reactivation versus those who had not. Renal function, autoinmunity andinflammation markers, and SLE reactivation risk was compared between both groups.Result: COVID-19 infection in SLE patients did not elevate lupus reactivation risk: OR: 0.8 (0.3-2.6), p: 0.7.Conclusion: COVID-19 is not, at the moment and as documented, a risk factor for SLE reactivation.
Fil: García, Carlos. Clínica de la Costa; Colombia. Universidad Simon Bolivar; Colombia
Fil: Aroca Martinez, Gustavo. Universidad Simon Bolivar; Colombia. Clínica de la Costa; Colombia
Fil: Velez Verbel, María de los Ángeles. Universidad Simon Bolivar; Colombia. Clínica de la Costa; Colombia
Fil: Martinez, Álvaro. Clínica de la Costa; Colombia
Fil: Sepulveda, Carlos. Clínica de la Costa; Colombia
Fil: Roncallo, Camilo. Clínica de la Costa; Colombia
Fil: Gutierrez Campo, Valentina. Clínica de la Costa; Colombia. Universidad Metropolitana; Colombia
Fil: Barraza Ahumada, Natalia. Clínica de la Costa; Colombia
Fil: Terrasa, Sergio Adrian. Hospital Italiano. Departamento de Medicina.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Musso, Carlos. Hospital Italiano. Departamento de Medicina.; Argentina. Universidad Simon Bolivar; Colombia
description Introduction: Systemic lupus erythematosus (SLE) is an autoimmune chronic multi-organic diseasecharacterized by a deregulated innate and adaptive response. A series of viral and bacterial agentshave been associated with SLE activation. Coronavirus family represents important infectiouspathogens in both humans and animals, being responsible for approximately one third of community acquired superior respiratory tract infections. At the end of 2019, a new coronavirus (SARS-CoV-2) was detected as responsible for the COVID-19 disease. It was decided to evaluate if SLE patients had a greater risk of lupus activation when contracting COVID-19.Material & Method: Sixty two COVID-19 infected SLE patients were studied, comparing thosewho had suffered lupus reactivation versus those who had not. Renal function, autoinmunity andinflammation markers, and SLE reactivation risk was compared between both groups.Result: COVID-19 infection in SLE patients did not elevate lupus reactivation risk: OR: 0.8 (0.3-2.6), p: 0.7.Conclusion: COVID-19 is not, at the moment and as documented, a risk factor for SLE reactivation.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/219815
García, Carlos; Aroca Martinez, Gustavo; Velez Verbel, María de los Ángeles; Martinez, Álvaro; Sepulveda, Carlos; et al.; Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?; International Journal Of Medical Science And Clinical Research Studies; International Journal Of Medical Science And Clinical Research Studies; 3; 3; 3-2023; 343-348
2767-8326
2767-8342
CONICET Digital
CONICET
url http://hdl.handle.net/11336/219815
identifier_str_mv García, Carlos; Aroca Martinez, Gustavo; Velez Verbel, María de los Ángeles; Martinez, Álvaro; Sepulveda, Carlos; et al.; Can Infection by Sars-Cov2 Induce Systemic Lupus Erythematosus Reactivation?; International Journal Of Medical Science And Clinical Research Studies; International Journal Of Medical Science And Clinical Research Studies; 3; 3; 3-2023; 343-348
2767-8326
2767-8342
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ijmscr.org/index.php/ijmscrs/article/view/641
info:eu-repo/semantics/altIdentifier/doi/10.47191/ijmscrs/v3-i3-13
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv International Journal Of Medical Science And Clinical Research Studies
publisher.none.fl_str_mv International Journal Of Medical Science And Clinical Research Studies
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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