Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure

Autores
Nuñez, Julio; Rabinovich, Gabriel Adrián; Sandino, Justo; Mainar, Luis; Palau, Patricia; Santas, Enrique; Villanueva, María Pilar; Nuñez, Eduardo; Bodi, Vicent; Chorro, Francisco; Miñana, Gema; Sanchis, Juan
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. Methods and Results: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. Conclusion: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of longterm mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml).
Fil: Nuñez, Julio. Universidad de Valencia; España
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sandino, Justo. Universidad de Valencia; España
Fil: Mainar, Luis. Universidad de Valencia; España
Fil: Palau, Patricia. Hospital de La Plana; España
Fil: Santas, Enrique. Universidad de Valencia; España
Fil: Villanueva, María Pilar. Hospital Clínico Universitario de Valencia; España
Fil: Nuñez, Eduardo. Universidad de Valencia; España
Fil: Bodi, Vicent. Universidad de Valencia; España
Fil: Chorro, Francisco. Universidad de Valencia; España
Fil: Miñana, Gema. Hospital de Manises; España
Fil: Sanchis, Juan. Universidad de Valencia; España
Materia
Galectin-3
Antigen Carbohydrate 125
Acute Heart Failure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/3155
Acceder
id CONICETDig_cc4510a764a71910fd0401db338e1a7c
oai_identifier_str oai:ri.conicet.gov.ar:11336/3155
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failureNuñez, JulioRabinovich, Gabriel AdriánSandino, JustoMainar, LuisPalau, PatriciaSantas, EnriqueVillanueva, María PilarNuñez, EduardoBodi, VicentChorro, FranciscoMiñana, GemaSanchis, JuanGalectin-3Antigen Carbohydrate 125Acute Heart Failurehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aims: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. Methods and Results: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. Conclusion: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of longterm mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml).Fil: Nuñez, Julio. Universidad de Valencia; EspañaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Sandino, Justo. Universidad de Valencia; EspañaFil: Mainar, Luis. Universidad de Valencia; EspañaFil: Palau, Patricia. Hospital de La Plana; EspañaFil: Santas, Enrique. Universidad de Valencia; EspañaFil: Villanueva, María Pilar. Hospital Clínico Universitario de Valencia; EspañaFil: Nuñez, Eduardo. Universidad de Valencia; EspañaFil: Bodi, Vicent. Universidad de Valencia; EspañaFil: Chorro, Francisco. Universidad de Valencia; EspañaFil: Miñana, Gema. Hospital de Manises; EspañaFil: Sanchis, Juan. Universidad de Valencia; EspañaPublic Library of Science2015-04-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/3155Nuñez, Julio; Rabinovich, Gabriel Adrián; Sandino, Justo; Mainar, Luis; Palau, Patricia; et al.; Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure; Public Library of Science; Plos One; 10; 4; 13-4-2015; 1-141932-62031932-6203enginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122360info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0122360info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)https://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:20:36Zoai:ri.conicet.gov.ar:11336/3155instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:20:36.823CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
title Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
spellingShingle Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
Nuñez, Julio
Galectin-3
Antigen Carbohydrate 125
Acute Heart Failure
title_short Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
title_full Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
title_fullStr Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
title_full_unstemmed Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
title_sort Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
dc.creator.none.fl_str_mv Nuñez, Julio
Rabinovich, Gabriel Adrián
Sandino, Justo
Mainar, Luis
Palau, Patricia
Santas, Enrique
Villanueva, María Pilar
Nuñez, Eduardo
Bodi, Vicent
Chorro, Francisco
Miñana, Gema
Sanchis, Juan
author Nuñez, Julio
author_facet Nuñez, Julio
Rabinovich, Gabriel Adrián
Sandino, Justo
Mainar, Luis
Palau, Patricia
Santas, Enrique
Villanueva, María Pilar
Nuñez, Eduardo
Bodi, Vicent
Chorro, Francisco
Miñana, Gema
Sanchis, Juan
author_role author
author2 Rabinovich, Gabriel Adrián
Sandino, Justo
Mainar, Luis
Palau, Patricia
Santas, Enrique
Villanueva, María Pilar
Nuñez, Eduardo
Bodi, Vicent
Chorro, Francisco
Miñana, Gema
Sanchis, Juan
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Galectin-3
Antigen Carbohydrate 125
Acute Heart Failure
topic Galectin-3
Antigen Carbohydrate 125
Acute Heart Failure
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. Methods and Results: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. Conclusion: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of longterm mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml).
Fil: Nuñez, Julio. Universidad de Valencia; España
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Sandino, Justo. Universidad de Valencia; España
Fil: Mainar, Luis. Universidad de Valencia; España
Fil: Palau, Patricia. Hospital de La Plana; España
Fil: Santas, Enrique. Universidad de Valencia; España
Fil: Villanueva, María Pilar. Hospital Clínico Universitario de Valencia; España
Fil: Nuñez, Eduardo. Universidad de Valencia; España
Fil: Bodi, Vicent. Universidad de Valencia; España
Fil: Chorro, Francisco. Universidad de Valencia; España
Fil: Miñana, Gema. Hospital de Manises; España
Fil: Sanchis, Juan. Universidad de Valencia; España
description Aims: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125. Methods and Results: We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints. Conclusion: In patients with acute heart failure, Gal-3 was strongly associated with higher risk of longterm mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml).
publishDate 2015
dc.date.none.fl_str_mv 2015-04-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/3155
Nuñez, Julio; Rabinovich, Gabriel Adrián; Sandino, Justo; Mainar, Luis; Palau, Patricia; et al.; Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure; Public Library of Science; Plos One; 10; 4; 13-4-2015; 1-14
1932-6203
1932-6203
url http://hdl.handle.net/11336/3155
identifier_str_mv Nuñez, Julio; Rabinovich, Gabriel Adrián; Sandino, Justo; Mainar, Luis; Palau, Patricia; et al.; Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure; Public Library of Science; Plos One; 10; 4; 13-4-2015; 1-14
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122360
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0122360
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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