Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep

Autores
Cabrera Fischer, Edmundo Ignacio; Camus, Juan Manuel; Barmak, Walter; Risk, Marcelo; Diaz, Alberto Alejandro; De Forteza, E.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purposes of this work were to, a) describe an acute animal model of severe cardiac failure induced by high doses of halothane, b) ana- lyze the effects of these overdoses of halothane on ar- terial wall dynamics and c) characterize the cardi- ovascular effects of halothane through the autonomic nervous system. Measurements were performed in six sheep before and after halothane administration (4%). A significative decrease was observed in mean aortic flow (P<0.05) and diameter (P<0.01) in heart failure with respect to control state (from 2.64±0.95 L.min-1 and 17.32±1.86 mm to 1.69±0.58 L.min-1 and 15.33±1.71 mm; respectively). A significantly de- crease was observed in mean (P<0.005), systolic (P<0.01) and diastolic (P<0.005) aortic pressure in heart failure (from 85.90±19.49 mmHg, 93.52±18.07 mmHg and 78.86±20.12 mmHg to 49.12±21.77 mmHg, 55.54±20.71 mmHg and 43.48±21.21 mmHg; respectively). Heart rate in control group (127.73±11.20 bpm) was significantly (P<0.05) higher than that observed in heart failure (107.15±13.53 bpm).
Fil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Camus, Juan Manuel. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barmak, Walter. Universidad Favaloro; Argentina
Fil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
Fil: De Forteza, E.. Universidad Favaloro; Argentina
Materia
Heart Failure
Animal Model
Halothane
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193428
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In SheepCabrera Fischer, Edmundo IgnacioCamus, Juan ManuelBarmak, WalterRisk, MarceloDiaz, Alberto AlejandroDe Forteza, E.Heart FailureAnimal ModelHalothanehttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2The purposes of this work were to, a) describe an acute animal model of severe cardiac failure induced by high doses of halothane, b) ana- lyze the effects of these overdoses of halothane on ar- terial wall dynamics and c) characterize the cardi- ovascular effects of halothane through the autonomic nervous system. Measurements were performed in six sheep before and after halothane administration (4%). A significative decrease was observed in mean aortic flow (P<0.05) and diameter (P<0.01) in heart failure with respect to control state (from 2.64±0.95 L.min-1 and 17.32±1.86 mm to 1.69±0.58 L.min-1 and 15.33±1.71 mm; respectively). A significantly de- crease was observed in mean (P<0.005), systolic (P<0.01) and diastolic (P<0.005) aortic pressure in heart failure (from 85.90±19.49 mmHg, 93.52±18.07 mmHg and 78.86±20.12 mmHg to 49.12±21.77 mmHg, 55.54±20.71 mmHg and 43.48±21.21 mmHg; respectively). Heart rate in control group (127.73±11.20 bpm) was significantly (P<0.05) higher than that observed in heart failure (107.15±13.53 bpm).Fil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Camus, Juan Manuel. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barmak, Walter. Universidad Favaloro; ArgentinaFil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: De Forteza, E.. Universidad Favaloro; ArgentinaPlanta Piloto de Ingeniería Química2011-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193428Cabrera Fischer, Edmundo Ignacio; Camus, Juan Manuel; Barmak, Walter; Risk, Marcelo; Diaz, Alberto Alejandro; et al.; Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep; Planta Piloto de Ingeniería Química; Latin American Applied Research; 41; 9-2011; 233-2390327-07931851-8796CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-07932011000300006info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:57Zoai:ri.conicet.gov.ar:11336/193428instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:57.597CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
title Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
spellingShingle Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
Cabrera Fischer, Edmundo Ignacio
Heart Failure
Animal Model
Halothane
title_short Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
title_full Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
title_fullStr Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
title_full_unstemmed Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
title_sort Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep
dc.creator.none.fl_str_mv Cabrera Fischer, Edmundo Ignacio
Camus, Juan Manuel
Barmak, Walter
Risk, Marcelo
Diaz, Alberto Alejandro
De Forteza, E.
author Cabrera Fischer, Edmundo Ignacio
author_facet Cabrera Fischer, Edmundo Ignacio
Camus, Juan Manuel
Barmak, Walter
Risk, Marcelo
Diaz, Alberto Alejandro
De Forteza, E.
author_role author
author2 Camus, Juan Manuel
Barmak, Walter
Risk, Marcelo
Diaz, Alberto Alejandro
De Forteza, E.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Heart Failure
Animal Model
Halothane
topic Heart Failure
Animal Model
Halothane
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The purposes of this work were to, a) describe an acute animal model of severe cardiac failure induced by high doses of halothane, b) ana- lyze the effects of these overdoses of halothane on ar- terial wall dynamics and c) characterize the cardi- ovascular effects of halothane through the autonomic nervous system. Measurements were performed in six sheep before and after halothane administration (4%). A significative decrease was observed in mean aortic flow (P<0.05) and diameter (P<0.01) in heart failure with respect to control state (from 2.64±0.95 L.min-1 and 17.32±1.86 mm to 1.69±0.58 L.min-1 and 15.33±1.71 mm; respectively). A significantly de- crease was observed in mean (P<0.005), systolic (P<0.01) and diastolic (P<0.005) aortic pressure in heart failure (from 85.90±19.49 mmHg, 93.52±18.07 mmHg and 78.86±20.12 mmHg to 49.12±21.77 mmHg, 55.54±20.71 mmHg and 43.48±21.21 mmHg; respectively). Heart rate in control group (127.73±11.20 bpm) was significantly (P<0.05) higher than that observed in heart failure (107.15±13.53 bpm).
Fil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Camus, Juan Manuel. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barmak, Walter. Universidad Favaloro; Argentina
Fil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
Fil: De Forteza, E.. Universidad Favaloro; Argentina
description The purposes of this work were to, a) describe an acute animal model of severe cardiac failure induced by high doses of halothane, b) ana- lyze the effects of these overdoses of halothane on ar- terial wall dynamics and c) characterize the cardi- ovascular effects of halothane through the autonomic nervous system. Measurements were performed in six sheep before and after halothane administration (4%). A significative decrease was observed in mean aortic flow (P<0.05) and diameter (P<0.01) in heart failure with respect to control state (from 2.64±0.95 L.min-1 and 17.32±1.86 mm to 1.69±0.58 L.min-1 and 15.33±1.71 mm; respectively). A significantly de- crease was observed in mean (P<0.005), systolic (P<0.01) and diastolic (P<0.005) aortic pressure in heart failure (from 85.90±19.49 mmHg, 93.52±18.07 mmHg and 78.86±20.12 mmHg to 49.12±21.77 mmHg, 55.54±20.71 mmHg and 43.48±21.21 mmHg; respectively). Heart rate in control group (127.73±11.20 bpm) was significantly (P<0.05) higher than that observed in heart failure (107.15±13.53 bpm).
publishDate 2011
dc.date.none.fl_str_mv 2011-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193428
Cabrera Fischer, Edmundo Ignacio; Camus, Juan Manuel; Barmak, Walter; Risk, Marcelo; Diaz, Alberto Alejandro; et al.; Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep; Planta Piloto de Ingeniería Química; Latin American Applied Research; 41; 9-2011; 233-239
0327-0793
1851-8796
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193428
identifier_str_mv Cabrera Fischer, Edmundo Ignacio; Camus, Juan Manuel; Barmak, Walter; Risk, Marcelo; Diaz, Alberto Alejandro; et al.; Description Of An Animal Model Of Acute Cardiac Failure: In Vivo Experiments In Sheep; Planta Piloto de Ingeniería Química; Latin American Applied Research; 41; 9-2011; 233-239
0327-0793
1851-8796
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-07932011000300006
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
publisher.none.fl_str_mv Planta Piloto de Ingeniería Química
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082677749317632
score 13.22299

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