Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina

Autores
Aulicino, Paula; Holmes, Edward; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 x 10(-3) substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for "pure" B and F viruses.
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Holmes, Edward. Universidad Estatal de Pensilvania; Estados Unidos
Fil: Rocco, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sen, Luisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Materia
HIV-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/244681
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in ArgentinaAulicino, PaulaHolmes, EdwardRocco, Carlos AlbertoMangano, Andrea María MercedesSen, LuisaHIV-1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 x 10(-3) substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for "pure" B and F viruses.Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Holmes, Edward. Universidad Estatal de Pensilvania; Estados UnidosFil: Rocco, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Sen, Luisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaAmerican Society for Microbiology2007-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/244681Aulicino, Paula; Holmes, Edward; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina; American Society for Microbiology; Journal of Virology; 81; 1; 1-2007; 427-4290022-538XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.01403-06info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:35Zoai:ri.conicet.gov.ar:11336/244681instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:35.476CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
title Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
spellingShingle Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
Aulicino, Paula
HIV-1
title_short Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
title_full Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
title_fullStr Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
title_full_unstemmed Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
title_sort Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina
dc.creator.none.fl_str_mv Aulicino, Paula
Holmes, Edward
Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
author Aulicino, Paula
author_facet Aulicino, Paula
Holmes, Edward
Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
author_role author
author2 Holmes, Edward
Rocco, Carlos Alberto
Mangano, Andrea María Mercedes
Sen, Luisa
author2_role author
author
author
author
dc.subject.none.fl_str_mv HIV-1
topic HIV-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 x 10(-3) substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for "pure" B and F viruses.
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Holmes, Edward. Universidad Estatal de Pensilvania; Estados Unidos
Fil: Rocco, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Sen, Luisa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
description The epidemic of human immunodeficiency virus type 1 (HIV-1) in Argentina is distinctive in that many infections are caused by subtype BF recombinant viruses. To determine their demographic history, we estimated the evolutionary rate, mode of population growth, and age of genetic diversity among 40 BF vpu sequences. This revealed one of the highest substitution rates reported for HIV-1, at 10.793 x 10(-3) substitutions per site per year, and a very rapid rate of population growth, with an initial mean epidemic doubling time of 3.72 months. This rapid population growth is compatible with an elevated fitness for subtype BF compared to that for "pure" B and F viruses.
publishDate 2007
dc.date.none.fl_str_mv 2007-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/244681
Aulicino, Paula; Holmes, Edward; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina; American Society for Microbiology; Journal of Virology; 81; 1; 1-2007; 427-429
0022-538X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/244681
identifier_str_mv Aulicino, Paula; Holmes, Edward; Rocco, Carlos Alberto; Mangano, Andrea María Mercedes; Sen, Luisa; Extremely Rapid Spread of Human Immunodeficiency Virus Type 1 BF Recombinants in Argentina; American Society for Microbiology; Journal of Virology; 81; 1; 1-2007; 427-429
0022-538X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/jvi.01403-06
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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