Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
- Autores
- Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; Carr, Jean; Sen, Luisa; Foley, Brian
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carr, Jean. University of Maryland; Estados Unidos
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados Unidos - Materia
-
HIV-1
CRF
HIV-1 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/243264
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strainsAulicino, PaulaGómez Carrillo, ManuelBello, GonzaloRocco, CarlosMangano, Andrea María MercedesCarr, JeanSen, LuisaFoley, BrianHIV-1CRFHIV-1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carr, Jean. University of Maryland; Estados UnidosFil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados UnidosElsevier Science2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243264Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-4471567-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567134812000044info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.01.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:12:01Zoai:ri.conicet.gov.ar:11336/243264instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:12:01.266CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
title |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
spellingShingle |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains Aulicino, Paula HIV-1 CRF HIV-1 |
title_short |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
title_full |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
title_fullStr |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
title_full_unstemmed |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
title_sort |
Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains |
dc.creator.none.fl_str_mv |
Aulicino, Paula Gómez Carrillo, Manuel Bello, Gonzalo Rocco, Carlos Mangano, Andrea María Mercedes Carr, Jean Sen, Luisa Foley, Brian |
author |
Aulicino, Paula |
author_facet |
Aulicino, Paula Gómez Carrillo, Manuel Bello, Gonzalo Rocco, Carlos Mangano, Andrea María Mercedes Carr, Jean Sen, Luisa Foley, Brian |
author_role |
author |
author2 |
Gómez Carrillo, Manuel Bello, Gonzalo Rocco, Carlos Mangano, Andrea María Mercedes Carr, Jean Sen, Luisa Foley, Brian |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
HIV-1 CRF HIV-1 |
topic |
HIV-1 CRF HIV-1 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes. Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz; Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Carr, Jean. University of Maryland; Estados Unidos Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados Unidos |
description |
The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/243264 Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-447 1567-1348 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/243264 |
identifier_str_mv |
Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-447 1567-1348 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567134812000044 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.01.003 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270181582176256 |
score |
13.13397 |