Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains

Autores
Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; Carr, Jean; Sen, Luisa; Foley, Brian
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carr, Jean. University of Maryland; Estados Unidos
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
Materia
HIV-1
CRF
HIV-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/243264
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/243264
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strainsAulicino, PaulaGómez Carrillo, ManuelBello, GonzaloRocco, CarlosMangano, Andrea María MercedesCarr, JeanSen, LuisaFoley, BrianHIV-1CRFHIV-1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carr, Jean. University of Maryland; Estados UnidosFil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados UnidosElsevier Science2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/243264Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-4471567-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567134812000044info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.01.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:33Zoai:ri.conicet.gov.ar:11336/243264instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:34.188CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
title Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
spellingShingle Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
Aulicino, Paula
HIV-1
CRF
HIV-1
title_short Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
title_full Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
title_fullStr Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
title_full_unstemmed Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
title_sort Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains
dc.creator.none.fl_str_mv Aulicino, Paula
Gómez Carrillo, Manuel
Bello, Gonzalo
Rocco, Carlos
Mangano, Andrea María Mercedes
Carr, Jean
Sen, Luisa
Foley, Brian
author Aulicino, Paula
author_facet Aulicino, Paula
Gómez Carrillo, Manuel
Bello, Gonzalo
Rocco, Carlos
Mangano, Andrea María Mercedes
Carr, Jean
Sen, Luisa
Foley, Brian
author_role author
author2 Gómez Carrillo, Manuel
Bello, Gonzalo
Rocco, Carlos
Mangano, Andrea María Mercedes
Carr, Jean
Sen, Luisa
Foley, Brian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HIV-1
CRF
HIV-1
topic HIV-1
CRF
HIV-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
Fil: Aulicino, Paula. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gómez Carrillo, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Bello, Gonzalo. Ministerio de Salud de Brasil. Fundación Oswaldo Cruz. Instituto Oswaldo Cruz;
Fil: Rocco, Carlos. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Mangano, Andrea María Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Carr, Jean. University of Maryland; Estados Unidos
Fil: Sen, Luisa. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Foley, Brian. Los Alamos National High Magnetic Field Laboratory; Estados Unidos
description The aim of this work is to characterize the full-length intersubtype recombinant structure of the HIV-1 Circulating Recombinant Form CRF17_BF. A single genome of CRF17_BF was originally described in 2001 as being largely similar to CRF12_BF. Since then, more genomes of CRF17_BF have been sequenced but not adequately described in publications. Here we describe CRF17_BF as a genuine CRF, and analyze its recombination pattern based on bootscan analyses, subtype signature patterns, and phylogenetic reconstruction of subtype-delimited segments. We show that CRF17_BF can be distinguished from CRF12_BF in several regions of the genome, including vpu, pol, env and nef. A complete and accurate characterization and description of recombination breakpoints in CRFs is required for a proper surveillance of HIV-1 genotypes, and important for epidemiological purposes.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/243264
Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-447
1567-1348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/243264
identifier_str_mv Aulicino, Paula; Gómez Carrillo, Manuel; Bello, Gonzalo; Rocco, Carlos; Mangano, Andrea María Mercedes; et al.; Characterization of full-length HIV-1 CRF17_BF genomes and comparison to the prototype CRF12_BF strains; Elsevier Science; Infection, Genetics and Evolution; 12; 2; 3-2012; 443-447
1567-1348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1567134812000044
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.01.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614519554310144
score 13.070432

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