Tracheal remodelling in response to hypoxia

Autores
Centanin, Lázaro; Gorr, Thomas A; Wappner, Pablo
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
Fil: Centanin, Lázaro. University of Heidelberg. Institute of Zoology; Alemania. Fundación Instituto Leloir; Argentina
Fil: Gorr, Thomas A. University of Zúrich. Institute of Veterinary Physiology; Suiza. Fundación Instituto Leloir; Argentina
Fil: Wappner, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
Materia
Tracheae
Plasticity
Hypoxia
Cell Autonomy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12643
Acceder
id CONICETDig_cb2fc9dcd921e92ac20fb9e342f6a661
oai_identifier_str oai:ri.conicet.gov.ar:11336/12643
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Tracheal remodelling in response to hypoxiaCentanin, LázaroGorr, Thomas AWappner, PabloTracheaePlasticityHypoxiaCell Autonomyhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.Fil: Centanin, Lázaro. University of Heidelberg. Institute of Zoology; Alemania. Fundación Instituto Leloir; ArgentinaFil: Gorr, Thomas A. University of Zúrich. Institute of Veterinary Physiology; Suiza. Fundación Instituto Leloir; ArgentinaFil: Wappner, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; ArgentinaElsevier Science2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12643Centanin, Lázaro; Gorr, Thomas A; Wappner, Pablo; Tracheal remodelling in response to hypoxia; Elsevier Science; Journal Of Insect Physiology; 56; 5; 5-2010; 447-4540022-1910enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022191009002212info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinsphys.2009.05.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:25:03Zoai:ri.conicet.gov.ar:11336/12643instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:25:04.162CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tracheal remodelling in response to hypoxia
title Tracheal remodelling in response to hypoxia
spellingShingle Tracheal remodelling in response to hypoxia
Centanin, Lázaro
Tracheae
Plasticity
Hypoxia
Cell Autonomy
title_short Tracheal remodelling in response to hypoxia
title_full Tracheal remodelling in response to hypoxia
title_fullStr Tracheal remodelling in response to hypoxia
title_full_unstemmed Tracheal remodelling in response to hypoxia
title_sort Tracheal remodelling in response to hypoxia
dc.creator.none.fl_str_mv Centanin, Lázaro
Gorr, Thomas A
Wappner, Pablo
author Centanin, Lázaro
author_facet Centanin, Lázaro
Gorr, Thomas A
Wappner, Pablo
author_role author
author2 Gorr, Thomas A
Wappner, Pablo
author2_role author
author
dc.subject.none.fl_str_mv Tracheae
Plasticity
Hypoxia
Cell Autonomy
topic Tracheae
Plasticity
Hypoxia
Cell Autonomy
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
Fil: Centanin, Lázaro. University of Heidelberg. Institute of Zoology; Alemania. Fundación Instituto Leloir; Argentina
Fil: Gorr, Thomas A. University of Zúrich. Institute of Veterinary Physiology; Suiza. Fundación Instituto Leloir; Argentina
Fil: Wappner, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina
description The insect tracheal system is a continuous tubular network that ramifies into progressively thinner branches to provide air directly to every organ and tissue throughout the body. During embryogenesis the basic architecture of the tracheal system develops in a stereotypical and genetically controlled manner. Later, in larval stages, the tracheal system becomes plastic, and adapts to particular oxygen needs of the different tissues of the body. Oxygen sensing is mediated by specific prolyl-4-hydroxylases that regulate protein stability of the alpha subunit of oxygen-responsive transcription factors from the HIF family. Tracheal cells are exquisitely sensitive to oxygen levels, modulating the expression of hypoxia-inducible proteins that mediate sprouting of tracheal branches in direction to oxygen-deprived tissues.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12643
Centanin, Lázaro; Gorr, Thomas A; Wappner, Pablo; Tracheal remodelling in response to hypoxia; Elsevier Science; Journal Of Insect Physiology; 56; 5; 5-2010; 447-454
0022-1910
url http://hdl.handle.net/11336/12643
identifier_str_mv Centanin, Lázaro; Gorr, Thomas A; Wappner, Pablo; Tracheal remodelling in response to hypoxia; Elsevier Science; Journal Of Insect Physiology; 56; 5; 5-2010; 447-454
0022-1910
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0022191009002212
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinsphys.2009.05.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1856403058656804864
score 13.115731

Publicaciones similares