Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?

Autores
González, Paula Mariela; Cabrera, Joaquin; Puntarulo, Susana Ángela
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell death. Aquatic animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to ferroptosis. The ferroptosis reaction can be regulated through the antioxidant defense system, in combination with the protein degradation structure, metabolism, and gene transcription. Early depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals, and the reduction of both GSH and ascorbate in photosynthetic organisms, are characteristic features of ferroptosis. Therefore, ferroptosis can be prevented if Fe chelators, certain antioxidants, and specifically regulating genes are activated. Thus, the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously understood. Much more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.
Fil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Cabrera, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
GLUTATHIONE
LABILE FE POOL
LIPID PEROXIDATION
OXIDATIVE STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227591
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227591
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?González, Paula MarielaCabrera, JoaquinPuntarulo, Susana ÁngelaGLUTATHIONELABILE FE POOLLIPID PEROXIDATIONOXIDATIVE STRESShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell death. Aquatic animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to ferroptosis. The ferroptosis reaction can be regulated through the antioxidant defense system, in combination with the protein degradation structure, metabolism, and gene transcription. Early depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals, and the reduction of both GSH and ascorbate in photosynthetic organisms, are characteristic features of ferroptosis. Therefore, ferroptosis can be prevented if Fe chelators, certain antioxidants, and specifically regulating genes are activated. Thus, the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously understood. Much more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.Fil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Cabrera, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaInstituto de Histología y Embriología2023-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227591González, Paula Mariela; Cabrera, Joaquin; Puntarulo, Susana Ángela; Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?; Instituto de Histología y Embriología; Biocell; 47; 5; 4-2023; 1177-11891667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://file.techscience.com/files/biocell/2023/TSP_BIOCELL-47-5/Biocell-47-05-27107/Biocell-47-27107.pdfinfo:eu-repo/semantics/altIdentifier/doi/10.32604/biocell.2023.027107info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:34:41Zoai:ri.conicet.gov.ar:11336/227591instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:34:41.685CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
title Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
spellingShingle Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
González, Paula Mariela
GLUTATHIONE
LABILE FE POOL
LIPID PEROXIDATION
OXIDATIVE STRESS
title_short Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
title_full Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
title_fullStr Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
title_full_unstemmed Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
title_sort Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?
dc.creator.none.fl_str_mv González, Paula Mariela
Cabrera, Joaquin
Puntarulo, Susana Ángela
author González, Paula Mariela
author_facet González, Paula Mariela
Cabrera, Joaquin
Puntarulo, Susana Ángela
author_role author
author2 Cabrera, Joaquin
Puntarulo, Susana Ángela
author2_role author
author
dc.subject.none.fl_str_mv GLUTATHIONE
LABILE FE POOL
LIPID PEROXIDATION
OXIDATIVE STRESS
topic GLUTATHIONE
LABILE FE POOL
LIPID PEROXIDATION
OXIDATIVE STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell death. Aquatic animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to ferroptosis. The ferroptosis reaction can be regulated through the antioxidant defense system, in combination with the protein degradation structure, metabolism, and gene transcription. Early depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals, and the reduction of both GSH and ascorbate in photosynthetic organisms, are characteristic features of ferroptosis. Therefore, ferroptosis can be prevented if Fe chelators, certain antioxidants, and specifically regulating genes are activated. Thus, the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously understood. Much more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.
Fil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Cabrera, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
description The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell death. Aquatic animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to ferroptosis. The ferroptosis reaction can be regulated through the antioxidant defense system, in combination with the protein degradation structure, metabolism, and gene transcription. Early depletion of non-enzymatic antioxidants like reduced glutathione (GSH) in animals, and the reduction of both GSH and ascorbate in photosynthetic organisms, are characteristic features of ferroptosis. Therefore, ferroptosis can be prevented if Fe chelators, certain antioxidants, and specifically regulating genes are activated. Thus, the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously understood. Much more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.
publishDate 2023
dc.date.none.fl_str_mv 2023-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227591
González, Paula Mariela; Cabrera, Joaquin; Puntarulo, Susana Ángela; Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?; Instituto de Histología y Embriología; Biocell; 47; 5; 4-2023; 1177-1189
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227591
identifier_str_mv González, Paula Mariela; Cabrera, Joaquin; Puntarulo, Susana Ángela; Fe dependent cellular alterations of oxidative balance in aquatic organisms. Could be ferroptosis involved?; Instituto de Histología y Embriología; Biocell; 47; 5; 4-2023; 1177-1189
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://file.techscience.com/files/biocell/2023/TSP_BIOCELL-47-5/Biocell-47-05-27107/Biocell-47-27107.pdf
info:eu-repo/semantics/altIdentifier/doi/10.32604/biocell.2023.027107
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto de Histología y Embriología
publisher.none.fl_str_mv Instituto de Histología y Embriología
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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