Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure

Autores
Galatro, Andrea Verónica; González, Paula Mariela; Malanga, Gabriela Fabiana; Robello, Elizabeth; Piloni, Natacha Estefanía; Puntarulo, Susana Ángela
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Oxidative damage to lipids was characterized in terms of the nature of the oxidant, the type of lipid, and the severity of the oxidation (Simontacchi et al., 2011). Even though malondialdehyde detection with the thiobarbituric acid reactive substances test (TBARS) is the most currently used assay for the determination of lipid oxidation, it is unspecific since the reaction can be reproduced by other biological compounds (Simontacchi et al., 2011). On the other hand, electron paramagnetic resonance (EPR) spectroscopy showed the capacity of detecting the presence of the lipid radicals (LR•) formed during peroxidation, by yielding unique and stable products with spin traps (Malanga and Puntarulo, 2012). Nitric oxide (NO) is recognized both, as a signaling molecule that regulates many enzyme activities, but as a toxic agent as well. It has been found that NO is able to protect animal and plant cell types from oxidative damage resulting from superoxide (O− 2 ), hydrogen peroxide (H2O2) and alkyl peroxides by acting as a terminator of free radical chain reactions (Wink et al., 1995, 1996; Yalowich et al., 1999; Beligni and Lamattina, 2002; Sharpe et al., 2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) interact through the reaction of O− 2 with NO, to generate peroxynitrite (ONOO−) at a rate close to diffusion. ONOO− acts as both, a nitrating agent and a powerful oxidant capable of modifying proteins (formation of nitrotyrosine), lipids (lipid oxidation, lipid nitration), and nucleic acids (DNA oxidation and DNA nitration) (Gisone et al., 2004). The purpose of this commentary is to point out that NO complex interactions with other cellular components lead to a wide range of effects depending on the biological system under study and the oxidative stress condition.
Fil: Galatro, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Materia
Nitric oxide
Lipid peroxidation
Photosynthetic organisms
Animals
Oxidative stress conditions
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21317
Acceder
id CONICETDig_9b3e46e42b2bd7b6ef7d01cdc562f75b
oai_identifier_str oai:ri.conicet.gov.ar:11336/21317
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposureGalatro, Andrea VerónicaGonzález, Paula MarielaMalanga, Gabriela FabianaRobello, ElizabethPiloni, Natacha EstefaníaPuntarulo, Susana ÁngelaNitric oxideLipid peroxidationPhotosynthetic organismsAnimalsOxidative stress conditionshttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Oxidative damage to lipids was characterized in terms of the nature of the oxidant, the type of lipid, and the severity of the oxidation (Simontacchi et al., 2011). Even though malondialdehyde detection with the thiobarbituric acid reactive substances test (TBARS) is the most currently used assay for the determination of lipid oxidation, it is unspecific since the reaction can be reproduced by other biological compounds (Simontacchi et al., 2011). On the other hand, electron paramagnetic resonance (EPR) spectroscopy showed the capacity of detecting the presence of the lipid radicals (LR•) formed during peroxidation, by yielding unique and stable products with spin traps (Malanga and Puntarulo, 2012). Nitric oxide (NO) is recognized both, as a signaling molecule that regulates many enzyme activities, but as a toxic agent as well. It has been found that NO is able to protect animal and plant cell types from oxidative damage resulting from superoxide (O− 2 ), hydrogen peroxide (H2O2) and alkyl peroxides by acting as a terminator of free radical chain reactions (Wink et al., 1995, 1996; Yalowich et al., 1999; Beligni and Lamattina, 2002; Sharpe et al., 2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) interact through the reaction of O− 2 with NO, to generate peroxynitrite (ONOO−) at a rate close to diffusion. ONOO− acts as both, a nitrating agent and a powerful oxidant capable of modifying proteins (formation of nitrotyrosine), lipids (lipid oxidation, lipid nitration), and nucleic acids (DNA oxidation and DNA nitration) (Gisone et al., 2004). The purpose of this commentary is to point out that NO complex interactions with other cellular components lead to a wide range of effects depending on the biological system under study and the oxidative stress condition.Fil: Galatro, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; ArgentinaFrontiers2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21317Galatro, Andrea Verónica; González, Paula Mariela; Malanga, Gabriela Fabiana; Robello, Elizabeth; Piloni, Natacha Estefanía; et al.; Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure; Frontiers; Frontiers in Physiology; 4; 8-2013; 1-3; 2761664-042XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fphys.2013.00276/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2013.00276info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797955/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:22Zoai:ri.conicet.gov.ar:11336/21317instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:22.698CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
title Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
spellingShingle Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
Galatro, Andrea Verónica
Nitric oxide
Lipid peroxidation
Photosynthetic organisms
Animals
Oxidative stress conditions
title_short Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
title_full Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
title_fullStr Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
title_full_unstemmed Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
title_sort Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure
dc.creator.none.fl_str_mv Galatro, Andrea Verónica
González, Paula Mariela
Malanga, Gabriela Fabiana
Robello, Elizabeth
Piloni, Natacha Estefanía
Puntarulo, Susana Ángela
author Galatro, Andrea Verónica
author_facet Galatro, Andrea Verónica
González, Paula Mariela
Malanga, Gabriela Fabiana
Robello, Elizabeth
Piloni, Natacha Estefanía
Puntarulo, Susana Ángela
author_role author
author2 González, Paula Mariela
Malanga, Gabriela Fabiana
Robello, Elizabeth
Piloni, Natacha Estefanía
Puntarulo, Susana Ángela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Nitric oxide
Lipid peroxidation
Photosynthetic organisms
Animals
Oxidative stress conditions
topic Nitric oxide
Lipid peroxidation
Photosynthetic organisms
Animals
Oxidative stress conditions
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Oxidative damage to lipids was characterized in terms of the nature of the oxidant, the type of lipid, and the severity of the oxidation (Simontacchi et al., 2011). Even though malondialdehyde detection with the thiobarbituric acid reactive substances test (TBARS) is the most currently used assay for the determination of lipid oxidation, it is unspecific since the reaction can be reproduced by other biological compounds (Simontacchi et al., 2011). On the other hand, electron paramagnetic resonance (EPR) spectroscopy showed the capacity of detecting the presence of the lipid radicals (LR•) formed during peroxidation, by yielding unique and stable products with spin traps (Malanga and Puntarulo, 2012). Nitric oxide (NO) is recognized both, as a signaling molecule that regulates many enzyme activities, but as a toxic agent as well. It has been found that NO is able to protect animal and plant cell types from oxidative damage resulting from superoxide (O− 2 ), hydrogen peroxide (H2O2) and alkyl peroxides by acting as a terminator of free radical chain reactions (Wink et al., 1995, 1996; Yalowich et al., 1999; Beligni and Lamattina, 2002; Sharpe et al., 2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) interact through the reaction of O− 2 with NO, to generate peroxynitrite (ONOO−) at a rate close to diffusion. ONOO− acts as both, a nitrating agent and a powerful oxidant capable of modifying proteins (formation of nitrotyrosine), lipids (lipid oxidation, lipid nitration), and nucleic acids (DNA oxidation and DNA nitration) (Gisone et al., 2004). The purpose of this commentary is to point out that NO complex interactions with other cellular components lead to a wide range of effects depending on the biological system under study and the oxidative stress condition.
Fil: Galatro, Andrea Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: González, Paula Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Malanga, Gabriela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Robello, Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Piloni, Natacha Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Puntarulo, Susana Ángela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
description Oxidative damage to lipids was characterized in terms of the nature of the oxidant, the type of lipid, and the severity of the oxidation (Simontacchi et al., 2011). Even though malondialdehyde detection with the thiobarbituric acid reactive substances test (TBARS) is the most currently used assay for the determination of lipid oxidation, it is unspecific since the reaction can be reproduced by other biological compounds (Simontacchi et al., 2011). On the other hand, electron paramagnetic resonance (EPR) spectroscopy showed the capacity of detecting the presence of the lipid radicals (LR•) formed during peroxidation, by yielding unique and stable products with spin traps (Malanga and Puntarulo, 2012). Nitric oxide (NO) is recognized both, as a signaling molecule that regulates many enzyme activities, but as a toxic agent as well. It has been found that NO is able to protect animal and plant cell types from oxidative damage resulting from superoxide (O− 2 ), hydrogen peroxide (H2O2) and alkyl peroxides by acting as a terminator of free radical chain reactions (Wink et al., 1995, 1996; Yalowich et al., 1999; Beligni and Lamattina, 2002; Sharpe et al., 2003). Reactive oxygen species (ROS) and reactive nitrogen species (RNS) interact through the reaction of O− 2 with NO, to generate peroxynitrite (ONOO−) at a rate close to diffusion. ONOO− acts as both, a nitrating agent and a powerful oxidant capable of modifying proteins (formation of nitrotyrosine), lipids (lipid oxidation, lipid nitration), and nucleic acids (DNA oxidation and DNA nitration) (Gisone et al., 2004). The purpose of this commentary is to point out that NO complex interactions with other cellular components lead to a wide range of effects depending on the biological system under study and the oxidative stress condition.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21317
Galatro, Andrea Verónica; González, Paula Mariela; Malanga, Gabriela Fabiana; Robello, Elizabeth; Piloni, Natacha Estefanía; et al.; Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure; Frontiers; Frontiers in Physiology; 4; 8-2013; 1-3; 276
1664-042X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21317
identifier_str_mv Galatro, Andrea Verónica; González, Paula Mariela; Malanga, Gabriela Fabiana; Robello, Elizabeth; Piloni, Natacha Estefanía; et al.; Nitric oxide and membrane lipid peroxidation in photosynthetic and non-photosynthetic organisms after oxidative stress exposure; Frontiers; Frontiers in Physiology; 4; 8-2013; 1-3; 276
1664-042X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fphys.2013.00276/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2013.00276
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797955/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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